2.1.3.3: ornithine carbamoyltransferase
This is an abbreviated version!
For detailed information about ornithine carbamoyltransferase, go to the full flat file.
Word Map on EC 2.1.3.3
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2.1.3.3
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coherence
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tomography
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eyes
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retinal
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macular
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acuity
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angiography
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nerve
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fiber
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vessel
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fundus
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choroid
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vision
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fluorescein
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coronary
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posterior
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spectral-domain
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edema
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modal
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glaucoma
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foveal
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retinopathy
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refract
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intraocular
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multimodal
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plexiform
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quadrant
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photography
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corneal
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autofluorescence
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best-corrected
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intravitreal
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neovascularization
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ophthalmic
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peripapillary
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glaucomatous
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stent
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ophthalmology
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ganglion
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subretinal
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vitrectomy
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analysis
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myopia
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biotechnology
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angiogram
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drug-eluting
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ellipsoid
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vitreous
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phantom
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medicine
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diagnostics
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traction
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anti-vegf
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indocyanine
- 2.1.3.3
-
coherence
-
tomography
- eyes
- retinal
-
macular
-
acuity
-
angiography
- nerve
- fiber
- vessel
-
fundus
- choroid
- vision
- fluorescein
- coronary
-
posterior
-
spectral-domain
- edema
-
modal
- glaucoma
-
foveal
- retinopathy
-
refract
-
intraocular
-
multimodal
-
plexiform
-
quadrant
-
photography
- corneal
-
autofluorescence
-
best-corrected
-
intravitreal
- neovascularization
-
ophthalmic
-
peripapillary
-
glaucomatous
-
stent
-
ophthalmology
- ganglion
-
subretinal
-
vitrectomy
- analysis
- myopia
- biotechnology
-
angiogram
-
drug-eluting
-
ellipsoid
- vitreous
-
phantom
- medicine
- diagnostics
-
traction
-
anti-vegf
-
indocyanine
Reaction
Synonyms
anabolic ornithine carbamoyltransferase, anabolic ornithine transcarbamoylase, AOTC, arcB gene product, ArgF, ArgK, aTtOTCase, carbamoyltransferase, carbamoyltransferase, ornithine, carbamylphosphate-ornithine transcarbamylase, catabolic ornithine carbamoyltransferase, catabolic ornithine transcarbamylase, citrulline phosphorylase, cOTC, L-ornithine carbamoyltransferase, L-ornithine carbamyltransferase, L-ornithine transcarbamylase, Lmo0036, MB1684, Mtb OTC, OCT, ornithine carbamoyltransferase, ornithine carbamoytransferase, ornithine carbamyl transferase, ornithine carbamyltransferase, ornithine transcarbamoylase, ornithine transcarbamylase, ornithine transcarbamylase 3, OTC, otcase, ROTCase
ECTree
2.1.3.3 ornithine carbamoyltransferaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.1.3.3 - ornithine carbamoyltransferase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
5-hydroxy-2-aminovaleric acid
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competitive vs. ornithine, uncompetitive vs. carbamoylphosphate
Acetylimidazole
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50 mM, 95% inhibition at 25°C in 100 mM imidazole-HCl, pH 7.5
Chlorosis-inducing toxin of Pseudomonas phaseolicola
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no more than 85% inhibition
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delta-N-(phosphonoacetyl)-L-ornithine
bisubstrate analogue inhibitor
N5-[amino(sulfoamino)phosphoryl]-L-ornithyl-L-alanyl-N6-carbamimidoyl-L-lysine
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inhibition of isoform 1 only
cystamine
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complete inactivation, activity is completely recovered by incubation with 20 mM dithiothreitol
cystamine
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complete inactivation, activity is completely recovered by incubation with 20 mM dithiothreitol
Delta-N-Phosphonoacetyl-L-ornithine
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competitive vs. carbamoylphosphate; transition state analogue
Delta-N-Phosphonoacetyl-L-ornithine
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0.001 mM, 86% inhibition, 0.0025 mM, 95% inhibition
L-norvaline
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competitive vs. ornithine, uncompetitive vs. carbamoylphosphate
N-delta-(phosphosulfamyl)ornithylalanylhomoarginine
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trivial name phaseolotoxin, 0.1 mM, 93% inhibition
N-delta-(phosphosulfamyl)ornithylalanylhomoarginine
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inhibition of isoform 1 only
ornithine
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at high concentrations; noncompetitive substrate inhibition vs. carbamoylphosphate
ornithine
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competitive vs. carbamoylphosphate in the presence of phosphate
p-hydroxymercuribenzoate
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inhibition is completely reversed by 2-mercaptoethanol
phosphate
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competitive vs. carbamoylphosphate, uncompetitive vs. ornithine
phosphate
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competitive vs. carbamoylphosphate, noncompetitive vs. ornithine
spermidine
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10 mM, more than 98% inhibition of arsenolytic cleavage activity
additional information
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effects of chemical modifications of specific residues on ligand binding and enzymatic activity
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additional information
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not inhibited by 10 mM 2-oxoglutarate, proline, glutamate, aspartate, acetylglutamate, pyruvate, oxaloacetate, glycine, acetylornithine, ATP, GTP, CTP, L-asparagine, arginine and glutamine
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additional information
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not inhibited by 10 mM 2-oxoglutarate, proline, glutamate, aspartate, acetylglutamate, pyruvate, oxaloacetate, glycine, acetylornithine, ATP, GTP, CTP, L-asparagine, arginine and glutamine
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additional information
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not inhibited by lysine and alpha-methyl-L-ornithine
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additional information
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not inhibited by 10 mM 2-oxoglutarate, proline, glutamate, aspartate, acetylglutamate, pyruvate, oxaloacetate, glycine, acetylornithine, ATP, GTP, CTP, L-asparagine, arginine and glutamine
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additional information
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effects of chemical modifications of specific residues on ligand binding and enzymatic activity
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additional information
Ndelta(N'-sulfo-diaminophosphinyl)-ornithyl-alanyl-homoarginine and Ndelta (N'-sulfo-diaminophosphinyl)-ornithine are irreversible inhibitor of ornithine transcarbamylase attributed to the chemical structure similarity with tetrahedral intermediates in OTCase mechanism. But the enzyme from Pseudomona syringae pv. phaseolicola shows resistance against the phytotoxic compounds.Inhibition of OTCase blocks the biosynthesis of arginine in vivo and leads to a reduction of protein synthesis
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additional information
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isoform 2 is not inhibited by phaseolotoxin and ornithine-delta-P(O)(NH2)-NH-SO3H
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