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Literature summary for 2.1.3.3 extracted from

  • Lusty, C.J.; Jilka, R.L.; Nietsch, E.H.
    Ornithine transcarbamylase of rat liver. Kinetic, physical, and chemical properties (1979), J. Biol. Chem., 254, 10030-10036.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glutamine
-
Rattus norvegicus
histidine
-
Rattus norvegicus
L-2-aminobutyrate
-
Rattus norvegicus
L-isoleucine
-
Rattus norvegicus
L-leucine
-
Rattus norvegicus
L-lysine weak Rattus norvegicus
L-norvaline
-
Rattus norvegicus
L-valine
-
Rattus norvegicus
methionine
-
Rattus norvegicus
additional information not inhibited by arginine Rattus norvegicus
phosphate
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39600
-
3 * 39600, SDS-PAGE, sedimentation equilibrium analysis in 6 M guanidine-HCl Rattus norvegicus
39900
-
3 * 39900, amino acid sequence Rattus norvegicus
112000
-
sedimentation equilibrium analysis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
885
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-70°C, 2% loss of activity per month Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine
-
Rattus norvegicus phosphate + L-citrulline
-
?
carbamoyl phosphate + lysine 4.3% of the rate with ornithine Rattus norvegicus phosphate + homocitrulline
-
?

Subunits

Subunits Comment Organism
trimer 3 * 39600, SDS-PAGE, sedimentation equilibrium analysis in 6 M guanidine-HCl Rattus norvegicus
trimer 3 * 39900, amino acid sequence Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
triethanolamine/acetate buffer Rattus norvegicus
7.9
-
HEPES/NaOH buffer Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.7 8.5 approx. 50% of maximal activity at pH 6.7 and 8.5, triethanolamine/acetate buffer Rattus norvegicus
7.2 8.3 71% of maximal activity at pH 7.2, 94% of maximal activity at pH 8.3, HEPES/NaOH buffer Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.8 9 60 min, stable Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.071
-
L-norvaline
-
Rattus norvegicus
0.25
-
phosphate
-
Rattus norvegicus
0.58
-
L-alpha-aminobutyrate
-
Rattus norvegicus
1.2
-
L-leucine
-
Rattus norvegicus
10.5
-
L-isoleucine
-
Rattus norvegicus
12.5
-
L-valine
-
Rattus norvegicus
40
-
L-histidin
-
Rattus norvegicus