2.1.3.3: ornithine carbamoyltransferase
This is an abbreviated version!
For detailed information about ornithine carbamoyltransferase, go to the full flat file.
Word Map on EC 2.1.3.3
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2.1.3.3
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coherence
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tomography
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eyes
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retinal
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macular
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acuity
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angiography
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nerve
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fiber
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vessel
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fundus
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choroid
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vision
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fluorescein
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coronary
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posterior
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spectral-domain
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edema
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modal
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glaucoma
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foveal
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retinopathy
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refract
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intraocular
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multimodal
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plexiform
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quadrant
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photography
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corneal
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autofluorescence
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best-corrected
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intravitreal
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neovascularization
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ophthalmic
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peripapillary
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glaucomatous
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stent
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ophthalmology
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ganglion
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subretinal
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vitrectomy
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analysis
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myopia
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biotechnology
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angiogram
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drug-eluting
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ellipsoid
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vitreous
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phantom
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medicine
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diagnostics
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traction
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anti-vegf
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indocyanine
- 2.1.3.3
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coherence
-
tomography
- eyes
- retinal
-
macular
-
acuity
-
angiography
- nerve
- fiber
- vessel
-
fundus
- choroid
- vision
- fluorescein
- coronary
-
posterior
-
spectral-domain
- edema
-
modal
- glaucoma
-
foveal
- retinopathy
-
refract
-
intraocular
-
multimodal
-
plexiform
-
quadrant
-
photography
- corneal
-
autofluorescence
-
best-corrected
-
intravitreal
- neovascularization
-
ophthalmic
-
peripapillary
-
glaucomatous
-
stent
-
ophthalmology
- ganglion
-
subretinal
-
vitrectomy
- analysis
- myopia
- biotechnology
-
angiogram
-
drug-eluting
-
ellipsoid
- vitreous
-
phantom
- medicine
- diagnostics
-
traction
-
anti-vegf
-
indocyanine
Reaction
Synonyms
anabolic ornithine carbamoyltransferase, anabolic ornithine transcarbamoylase, AOTC, arcB gene product, ArgF, ArgK, aTtOTCase, carbamoyltransferase, carbamoyltransferase, ornithine, carbamylphosphate-ornithine transcarbamylase, catabolic ornithine carbamoyltransferase, catabolic ornithine transcarbamylase, citrulline phosphorylase, cOTC, L-ornithine carbamoyltransferase, L-ornithine carbamyltransferase, L-ornithine transcarbamylase, Lmo0036, MB1684, Mtb OTC, OCT, ornithine carbamoyltransferase, ornithine carbamoytransferase, ornithine carbamyl transferase, ornithine carbamyltransferase, ornithine transcarbamoylase, ornithine transcarbamylase, ornithine transcarbamylase 3, OTC, otcase, ROTCase
ECTree
2.1.3.3 ornithine carbamoyltransferaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 2.1.3.3 - ornithine carbamoyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
carbamoyl phosphate + canaline
O-ureidohomoserine + phosphate
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66fold higher activity with canaline than with ornithine, enzyme may play a role in canavanine synthesis
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?
carbamoyl phosphate + L-Orn-Ala-hArg
phosphate + L-Cit-Ala-hArg
the enzyme produces Cit-Ala-hArg from tripeptide Orn-Ala-hArg and carbamyl phosphate as substrates
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-
?
carbamoyl phosphate + L-Orn-Ala-hArg
phosphate + L-Cit-Ala-hArg
the enzyme produces Cit-Ala-hArg from tripeptide Orn-Ala-hArg and carbamyl phosphate as substrates
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-
?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
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-
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?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
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-
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?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
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-
-
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?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
-
-
-
r
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
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-
-
-
r
carbamoyl phosphate + L-ornithine
phosphate + citrulline
catalyzes the sixth step in arginine biosynthesis
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-
r
carbamoyl phosphate + L-ornithine
phosphate + citrulline
catalyzes the sixth step in arginine biosynthesis
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-
r
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
Arundinaria sp.
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cytoplasmic form has predominantly catabolic function, mitochondrial form has anabolic function
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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anabolic function
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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anabolic function
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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enzyme seems to be involved in a bicarbonate-fixing pathway
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-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
anabolic function
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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enzyme belongs to the arginine biosynthesis pathway
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r
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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ornithine transcarbamylase deficiency is the most common inherited disorder of the urea cycle and is transmitted as an X-linked trait, defects in the OTC gene, especially at clusters of the substrate binding sites, cause a block in ureagenesis resulting in hyperammonemia, which can lead to brain damage and death
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-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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-
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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enzyme is involved in the biosynthesis of arginine in many organisms and participates in the urea cycle of mammals
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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anabolic function
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ir
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
there is no preferential partitioning of carbamoyl phosphate between the arginine and pyrimidine biosynthetic pathways. Channeling must occur during the dynamic association of coupled enzymes pairs
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-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
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-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
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-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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first step in arginine biosynthesis
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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catalyzes the last step of mitochondrial citrulline synthesis
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
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-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
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?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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-
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?
additional information
?
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involved in arginine metabolism
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-
?
additional information
?
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involved in arginine metabolism
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-
?
additional information
?
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key protein involved in the degradation of arginine during malolactic fermentation
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-
?
additional information
?
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Lentilactobacillus hilgardii CETC 4786 / ATCC 8290
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key protein involved in the degradation of arginine during malolactic fermentation
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-
?
additional information
?
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Lmo0036 is an ornithine carbamoyltransferase and also a putrescine carbamoyltransferase, EC 2.1.3.6, catalysing reversible ornithine and putrescine carbamoyltransfer reactions
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-
?
additional information
?
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Lmo0036 is an ornithine carbamoyltransferase and also a putrescine carbamoyltransferase, EC 2.1.3.6, catalysing reversible ornithine and putrescine carbamoyltransfer reactions
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-
?
