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Literature summary for 2.1.3.3 extracted from

  • Tricot, C.; Schmid, S.; Baur, H.; Villeret, V.; Dideberg, O.; Haas, D.; Stalon, V.
    Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Changes of allosteric properties resulting from modifications at the C-terminus (1994), Eur. J. Biochem., 221, 555-561.
    View publication on PubMed
Search for more literature for 2.1.3.3

Activating Compound

Activating Compound Comment Organism Structure
AMP strong allosteric activator, 1.5 mM, half-maximal activation Pseudomonas aeruginosa
CMP strong allosteric activator Pseudomonas aeruginosa
GMP allosteric activator Pseudomonas aeruginosa
phosphate presumably via interaction with the carbamoyl phosphate-binding site Pseudomonas aeruginosa
UMP allosteric activator Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
1,4-diaminobutane 10 mM; 10 mM, 45% inhibition Pseudomonas aeruginosa
spermidine 10 mM, 93% inhibition, 3.7 mM, 50% inhibition Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 12 * 38000, SDS-PAGE Pseudomonas aeruginosa
420000
-
 gel filtration Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
 catabolic ornithine carbamoyltransferase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine catabolic ornithine carbamoyltransferase, catalyzes the reverse reaction, i.e. the cleavage of citrulline Pseudomonas aeruginosa phosphate + L-citrulline
-
 ?

Subunits

Subunits Comment Organism
dodecamer 12 * 38000, SDS-PAGE Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 at 10 mM carbamoyl phosphate, sharp decrease of activity above Pseudomonas aeruginosa

pH Range

pH Minimum pH Maximum Comment Organism
6 7.2 at 10 mM carbamoyl phosphate, sharp decrease in activity above Pseudomonas aeruginosa