2.1.3.3: ornithine carbamoyltransferase
This is an abbreviated version!
For detailed information about ornithine carbamoyltransferase, go to the full flat file.
Word Map on EC 2.1.3.3
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2.1.3.3
-
coherence
-
tomography
-
eyes
-
retinal
-
macular
-
acuity
-
angiography
-
nerve
-
fiber
-
vessel
-
fundus
-
choroid
-
vision
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fluorescein
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coronary
-
posterior
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spectral-domain
-
edema
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modal
-
glaucoma
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foveal
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retinopathy
-
refract
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intraocular
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multimodal
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plexiform
-
quadrant
-
photography
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corneal
-
autofluorescence
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best-corrected
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intravitreal
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neovascularization
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ophthalmic
-
peripapillary
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glaucomatous
-
stent
-
ophthalmology
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ganglion
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subretinal
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vitrectomy
-
analysis
-
myopia
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biotechnology
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angiogram
-
drug-eluting
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ellipsoid
-
vitreous
-
phantom
-
medicine
-
diagnostics
-
traction
-
anti-vegf
-
indocyanine
- 2.1.3.3
-
coherence
-
tomography
- eyes
- retinal
-
macular
-
acuity
-
angiography
- nerve
- fiber
- vessel
-
fundus
- choroid
- vision
- fluorescein
- coronary
-
posterior
-
spectral-domain
- edema
-
modal
- glaucoma
-
foveal
- retinopathy
-
refract
-
intraocular
-
multimodal
-
plexiform
-
quadrant
-
photography
- corneal
-
autofluorescence
-
best-corrected
-
intravitreal
- neovascularization
-
ophthalmic
-
peripapillary
-
glaucomatous
-
stent
-
ophthalmology
- ganglion
-
subretinal
-
vitrectomy
- analysis
- myopia
- biotechnology
-
angiogram
-
drug-eluting
-
ellipsoid
- vitreous
-
phantom
- medicine
- diagnostics
-
traction
-
anti-vegf
-
indocyanine
Reaction
Synonyms
anabolic ornithine carbamoyltransferase, anabolic ornithine transcarbamoylase, AOTC, arcB gene product, ArgF, ArgK, aTtOTCase, carbamoyltransferase, carbamoyltransferase, ornithine, carbamylphosphate-ornithine transcarbamylase, catabolic ornithine carbamoyltransferase, catabolic ornithine transcarbamylase, citrulline phosphorylase, cOTC, L-ornithine carbamoyltransferase, L-ornithine carbamyltransferase, L-ornithine transcarbamylase, Lmo0036, MB1684, Mtb OTC, OCT, ornithine carbamoyltransferase, ornithine carbamoytransferase, ornithine carbamyl transferase, ornithine carbamyltransferase, ornithine transcarbamoylase, ornithine transcarbamylase, ornithine transcarbamylase 3, OTC, otcase, ROTCase
ECTree
2.1.3.3 ornithine carbamoyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.3.3 - ornithine carbamoyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
arsenate + L-citrulline
carbamoylarsenate + L-ornithine
-
pseudo-reverse reaction, arsenate is first coupled to citrulline, followed by elimination of carbamoylarsenate
-
r
3'-hydroxymethylcephem + carbamoyl phosphate
cephamycin C + phosphate
-
-
-
?
3'-hydroxymethylcephem + carbamoyl phosphate
cephamycin C + phosphate
-
-
-
?
carbamoyl phosphate + canaline
O-ureidohomoserine + phosphate
-
66fold higher activity with canaline than with ornithine
-
?
carbamoyl phosphate + canaline
O-ureidohomoserine + phosphate
-
isoform 2 shows 13times higher canaline-dependent transcarbamoylase activity than ornithine-dependent transcarbamoylase activity
-
-
?
carbamoyl phosphate + canaline
O-ureidohomoserine + phosphate
-
66fold higher activity with canaline than with ornithine, enzyme may play a role in canavanine synthesis
-
?
carbamoyl phosphate + L-Orn-Ala-hArg
phosphate + L-Cit-Ala-hArg
-
-
-
?
carbamoyl phosphate + L-Orn-Ala-hArg
phosphate + L-Cit-Ala-hArg
the enzyme produces Cit-Ala-hArg from tripeptide Orn-Ala-hArg and carbamyl phosphate as substrates
-
-
?
carbamoyl phosphate + L-Orn-Ala-hArg
phosphate + L-Cit-Ala-hArg
-
-
-
?
carbamoyl phosphate + L-Orn-Ala-hArg
phosphate + L-Cit-Ala-hArg
the enzyme produces Cit-Ala-hArg from tripeptide Orn-Ala-hArg and carbamyl phosphate as substrates
-
-
?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
-
-
-
?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
the mechanism of the aOTC-catalyzed reaction involves nucleophilic attack of the electron pair of the epsilon-amino group of L-ornithine on the carbonyl group of carbamoyl phosphate
-
-
?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
-
-
-
?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
the mechanism of the aOTC-catalyzed reaction involves nucleophilic attack of the electron pair of the epsilon-amino group of L-ornithine on the carbonyl group of carbamoyl phosphate
-
-
?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
-
-
-
-
?
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
-
-
-
r
carbamoyl phosphate + L-ornithine
L-citrulline + phosphate
-
-
-
-
r
carbamoyl phosphate + L-ornithine
phosphate + citrulline
catalyzes the sixth step in arginine biosynthesis
-
-
r
carbamoyl phosphate + L-ornithine
phosphate + citrulline
catalyzes the sixth step in arginine biosynthesis
-
-
r
carbamoyl phosphate + L-ornithine
phosphate + citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
Arundinaria sp.
-
cytoplasmic form has predominantly catabolic function, mitochondrial form has anabolic function
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
highly specific for L-ornithine at pH 8.0
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
isoform 1 shows 14times higher ornithine-dependent transcarbamoylase activity than canaline-dependent transcarbamoylase activity
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
anabolic function
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
anabolic function
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
enzyme seems to be involved in a bicarbonate-fixing pathway
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
anabolic function
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
highly specific for L-ornithine at pH 8.0
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
enzyme belongs to the arginine biosynthesis pathway
-
r
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
catabolic ornithine carbamoyltransferase, catalyzes the reverse reaction, i.e. the cleavage of citrulline
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
ornithine transcarbamylase deficiency is the most common inherited disorder of the urea cycle and is transmitted as an X-linked trait, defects in the OTC gene, especially at clusters of the substrate binding sites, cause a block in ureagenesis resulting in hyperammonemia, which can lead to brain damage and death
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
the carbamoyl phosphate binding site contains the highly conserved motif Ser90-Thr91-Arg92-Thr93-Arg94, the ornithine binding site contains the His302-Cys303-Leu304-Pro305 motif
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
enzyme also catalyzes the reactions of EC 2.1.3.6, EC 2.7.2.2 and EC 3.5.3.12, thus acting as putrescine synthase converting agmatine and ornithine into putrescine and citrulline
-
r
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
enzyme is involved in the biosynthesis of arginine in many organisms and participates in the urea cycle of mammals
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?, r
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
very low activity with canaline
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
catabolic ornithine carbamoyltransferase, catalyzes the reverse reaction, i.e. the cleavage of citrulline
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
ir
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
anabolic function
-
ir
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
there is no preferential partitioning of carbamoyl phosphate between the arginine and pyrimidine biosynthetic pathways. Channeling must occur during the dynamic association of coupled enzymes pairs
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
first step in arginine biosynthesis
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
catalyzes the last step of mitochondrial citrulline synthesis
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
enzyme catalyzes the synthesis of delta-acetyl ornithine at 0.3-0.5% the rate of citrulline synthesis at pH 8.5 when acetyl phosphate replaces carbamoyl phosphate
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
enzyme catalyzes the synthesis of delta-acetyl ornithine at 0.3-0.5% the rate of citrulline synthesis at pH 8.5 when acetyl phosphate replaces carbamoyl phosphate
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
?
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
-
-
-
?
carbamoyl phosphate + lysine
phosphate + homocitrulline
-
at alkaline pH
-
?
carbamoyl phosphate + lysine
phosphate + homocitrulline
-
at alkaline pH
-
?
carbamoyl phosphate + lysine
phosphate + homocitrulline
-
4.3% of the rate with ornithine
-
?
phosphate + L-citrulline
carbamoylphosphate + L-ornithine
-
catabolic carbamoyltransferase
-
-
?
additional information
?
-
in addition to using putrescine, see EC 2.1.3.6, the enzyme can utilize L-ornithine as a poor substrate. Differences between the respective 230 and SMG loops of putrescine transcarbamoylase PTC and OTC appear to account for the differential preference of these enzymes for putrescine and ornithine, active center and the discrimination mechanism between putrescine and ornithine, overview
-
-
?
additional information
?
-
OTC-t1 and OTC-t2 transcripts display heterogeneity at the cleavage sites in a tissue-dependent manner
-
-
?
additional information
?
-
-
OTC-t1 and OTC-t2 transcripts display heterogeneity at the cleavage sites in a tissue-dependent manner
-
-
?
additional information
?
-
-
involved in arginine metabolism
-
-
?
additional information
?
-
-
involved in arginine metabolism
-
-
?
additional information
?
-
-
key protein involved in the degradation of arginine during malolactic fermentation
-
-
?
additional information
?
-
Lentilactobacillus hilgardii CETC 4786 / ATCC 8290
-
key protein involved in the degradation of arginine during malolactic fermentation
-
-
?
additional information
?
-
-
Lmo0036 is an ornithine carbamoyltransferase and also a putrescine carbamoyltransferase, EC 2.1.3.6, catalysing reversible ornithine and putrescine carbamoyltransfer reactions
-
-
?
additional information
?
-
-
Lmo0036 is an ornithine carbamoyltransferase and also a putrescine carbamoyltransferase, EC 2.1.3.6, catalysing reversible ornithine and putrescine carbamoyltransfer reactions
-
-
?
additional information
?
-
both substrates are unable to bind in a proper orientation in the active site pocket and this can be due to the differently oriented side chains. This suggests that the active site geometry should also undergo fine tuning besides the large structural changes as the enzyme switches from completely open to a substrate bound closed state
-
-
?
additional information
?
-
-
both substrates are unable to bind in a proper orientation in the active site pocket and this can be due to the differently oriented side chains. This suggests that the active site geometry should also undergo fine tuning besides the large structural changes as the enzyme switches from completely open to a substrate bound closed state
-
-
?
additional information
?
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
both substrates are unable to bind in a proper orientation in the active site pocket and this can be due to the differently oriented side chains. This suggests that the active site geometry should also undergo fine tuning besides the large structural changes as the enzyme switches from completely open to a substrate bound closed state
-
-
?
