Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.3.3 extracted from

  • Galkin, A.; Kulakova, L.; Wu, R.; Gong, M.; Dunaway-Mariano, D.; Herzberg, O.
    X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia (2009), Proteins Struct. Funct. Bioinform., 76, 1049-1053.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Giardia intestinalis

Crystallization (Commentary)

Crystallization (Comment) Organism
one protein molecule per asymmetric unit, trimeric structure Giardia intestinalis

Inhibitors

Inhibitors Comment Organism Structure
delta-N-(phosphonacetyl)-L-ornithine
-
Giardia intestinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
L-ornithine pH 8.0, 37°C Giardia intestinalis
0.13
-
Carbamoyl phosphate pH 8.0, 37°C Giardia intestinalis
2.3
-
phosphate pH 8.0, 37°C Giardia intestinalis
10.4
-
L-citrulline pH 8.0, 37°C Giardia intestinalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36494
-
3 * 36494, calculated Giardia intestinalis
90000
-
gel filtration Giardia intestinalis

Organism

Organism UniProt Comment Textmining
Giardia intestinalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine
-
Giardia intestinalis phosphate + L-citrulline
-
r
phosphate + L-citrulline
-
Giardia intestinalis carbamoyl phosphate + L-ornithine
-
r

Subunits

Subunits Comment Organism
trimer 3 * 36494, calculated Giardia intestinalis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7.9
-
phosphate pH 8.0, 37°C Giardia intestinalis
8.1
-
L-citrulline pH 8.0, 37°C Giardia intestinalis
82
-
Carbamoyl phosphate pH 8.0, 37°C Giardia intestinalis
94.2
-
L-ornithine pH 8.0, 37°C Giardia intestinalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000025
-
delta-N-(phosphonacetyl)-L-ornithine pH 8.0, 37°C Giardia intestinalis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
780
-
L-citrulline pH 8.0, 37°C Giardia intestinalis
3400
-
phosphate pH 8.0, 37°C Giardia intestinalis
650000
-
Carbamoyl phosphate pH 8.0, 37°C Giardia intestinalis
880000
-
L-ornithine pH 8.0, 37°C Giardia intestinalis