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Information on EC - CTP synthase (glutamine hydrolysing)

for references in articles please use BRENDA:EC6.3.4.2
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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
       CTP synthase (glutamine hydrolysing)
IUBMB Comments
The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC, glutaminase), and the active site where CTP synthesis takes place. The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP [4,5]. Ammonia then reacts with this intermediate generating CTP and a phosphate. The enzyme can also use ammonia from the surrounding solution [3,6].
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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CTP synthase, CTP synthase 1, CTP synthetase, CTP synthetase 1, CTPS, CTPS1, CTPS2, CTPsyn, CTS, cytidine 5'-triphosphate synthase, more
ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate
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ATP + UTP + NH3 = ADP + phosphate + CTP
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L-glutamine + H2O = L-glutamate + NH3
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