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Literature summary for 6.3.4.2 extracted from
- Human cytidine triphosphate synthetase 1 interacting proteins (2008), Nucleosides Nucleotides Nucleic Acids, 27, 850-857.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GTP | - |
Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of wild-type and mutant enzymes in HEK-293 cells, co-expression with GST-tagged Xenopus laevis peptidyl prolyl isomerase Pin1 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S575A | site-directed mutagenesis the mutant does not interact with peptidyl prolyl isomerase Pin1 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclopentenyl cytosine | a highly specific inhibitor of CTPS1, in vivo inhibition leads to alterations in the cell nuclei and microtubule network, overview | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microtubule | - |
Homo sapiens | 5874 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + UTP + NH3 | Homo sapiens | CTPS1 is involved in microtubule network formation and/or stabilzation, overview | ADP + phosphate + CTP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + UTP + NH3 | - |
Homo sapiens | ADP + phosphate + CTP | - |
? | |
| ATP + UTP + NH3 | CTPS1 is involved in microtubule network formation and/or stabilzation, overview | Homo sapiens | ADP + phosphate + CTP | - |
? | |
| additional information | CTPS1 interacts with the GST-tagged peptidyl prolyl isomerase Pin1 from Xenopus laevis in a Ser575 phosphorylation-dependent manner, the CTPS1 also binds several other enzyme, e.g. alpha-tubulin, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTP synthetase 1 | - |
Homo sapiens |
| CTPS1 | - |
Homo sapiens |
| cytidine triphosphate synthetase 1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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