Ligand L-glutamic acid

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Basic Ligand Information

Molecular Structure
Picture of L-glutamic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H9NO4
L-glutamic acid
WHUUTDBJXJRKMK-VKHMYHEASA-N
Synonyms:
(2S)-2-aminopentanedioic acid, alpha-L-Glu, Glu, glutamate, glutamic acid, glutaminic acid, L-(+)-glutamic acid, L-Glu, L- glutamate, L-glutamate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (122 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+
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L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram
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L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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L-glutamate + H2O + O2 = 2-oxopentanedioate + NH3 + H2O2
show the reaction diagram
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2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+
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methylamine + L-glutamate = NH3 + N-methyl-L-glutamate
show the reaction diagram
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5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
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acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate
show the reaction diagram
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N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate
show the reaction diagram
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5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
show the reaction diagram
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O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
show the reaction diagram
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2 S-adenosyl-L-methionine + glutamate = 2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
show the reaction diagram
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(3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate = (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate = dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate = 8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
show the reaction diagram
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N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate = N2-acetyl-L-ornithine + 2-oxoglutarate
show the reaction diagram
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N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate = N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
show the reaction diagram
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imidazol-5-yl-pyruvate + L-glutamate = histidine + 2-oxoglutarate
show the reaction diagram
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glyoxylate + L-glutamate = glycine + 2-oxoglutarate
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3-methyl-2-oxobutyrate + L-glutamate = L-valine + 2-oxoglutarate
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L-2-amino-4-oxobutanoate + L-glutamate = L-2,4-diaminobutanoate + 2-oxoglutarate
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L-glutamate + 3-phosphohydroxypyruvate = O-phospho-L-serine + 2-oxoglutarate
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3-methyl-2-oxobutanoate + L-glutamate = L-valine + 2-oxoglutarate
show the reaction diagram
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4-hydroxyphenylglyoxylate + L-glutamate = D-4-hydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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prephenate + L-glutamate = L-arogenate + 2-oxoglutarate
show the reaction diagram
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L-glutamate + tetrahydrodipicolinate + H2O = LL-diaminopimelate + 2-oxoglutarate
show the reaction diagram
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UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate = UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
show the reaction diagram
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3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate = L-histidinol phosphate + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate = dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate
show the reaction diagram
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UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate = UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine + 2-oxoglutarate
show the reaction diagram
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dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate = dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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ATP + L-glutamate = ADP + L-glutamate 5-phosphate
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ATP + L-glutamate = ADP + alpha-L-glutamyl phosphate
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L-glutamate = 3-aminopentanedioate
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Glu = ?
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ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu
show the reaction diagram
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ATP + L-glutamate + tRNAGln = AMP + diphosphate + glutamyl-tRNAGln
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ATP + L-glutamate + tRNAAsp = AMP + diphosphate + L-glutamyl-tRNAAsp
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ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate
show the reaction diagram
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ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine
show the reaction diagram
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ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
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ATP + L-glutamate + histamine = products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine
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L-glutamate + GTP + coenzyme F420-0 = GDP + phosphate + coenzyme gamma-F420-1
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ATP + coenzyme gamma-F420-2 + L-glutamate = ADP + phosphate + coenzyme alpha-F420-3
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ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
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ATP + UDP-N-acetylmuramoyl-L-Ala + Glu = ?
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ATP + citrate + L-glutamate = ADP + phosphate + N-citryl-L-glutamate
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ATP + [LysW]-C-terminal-L-glutamate + L-glutamate = ADP + phosphate + [LysW]-C-terminal-gamma-(L-glutamyl)-L-glutamate
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ATP + alpha-tubulin + L-glutamate = L-glutamyl-alpha-tubulin + ADP + phosphate
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ATP + tyramine + L-glutamate = ADP + phosphate + gamma-glutamyltyramine
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ATP + H2O + L-Glu/out = ADP + phosphate + L-Glu/in
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ATP + H2O + glutamate/out = ADP + phosphate + glutamate/in
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (162 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + NH3 + NADH = L-glutamate + H2O + NAD+
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L-saccharopine + H2O + O2 = L-2-aminoadipate 6-semialdehyde + L-glutamate + H2O2
show the reaction diagram
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N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor
show the reaction diagram
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kanosamine 6-phosphate + 2-oxoglutarate = 3-dehydro-D-glucose 6-phosphate + L-glutamate
show the reaction diagram
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(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
show the reaction diagram
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N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate-gamma-semialdehyde + L-glutamate
show the reaction diagram
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(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate
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L-ornithine + 2-oxoglutarate = DELTA1-pyrroline-5-carboxylate + L-glutamate
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L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
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L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
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(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
show the reaction diagram
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4-hydroxy-L-glutamate + oxo acid = 4-hydroxy-2-oxoglutarate + L-glutamate
show the reaction diagram
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3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
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L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
show the reaction diagram
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L-tryptophan + 2-oxoglutarate = L-glutamate + 3-indole-2-oxopropanoate
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L-cysteine + 2-oxoglutarate = L-glutamate + beta-mercaptopyruvate
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L-lysine + 2-oxoglutarate = 2-aminoadipate 6-semialdehyde + L-glutamate
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L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
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5-aminopentanoate + 2-oxoglutarate = 5-oxovalerate + L-glutamate
show the reaction diagram
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L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
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dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
show the reaction diagram
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6-acetamido-3-aminohexanoate + 2-oxoglutarate = 6-acetamido-3-oxohexanoate + L-glutamate
show the reaction diagram
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L-kynurenine + 2-oxoglutarate = kynurenic acid + L-glutamate + H2O
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D-4-hydroxyphenylglycine + 2-oxoglutarate = 4-hydroxyphenylglyoxylate + L-glutamate
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S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = S-(4-bromophenyl)-3-thiopyruvate + L-glutamate
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L-2,5-diaminopentanoate + 2-oxoglutarate = 5-amino-2-oxopentanoate + L-glutamate
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nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate
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LL-diaminopimelate + 2-oxoglutarate = L-glutamate + tetrahydrodipicolinate + H2O
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chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
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chorismate + L-glutamine = (2S)-2-amino-4-deoxychorismate + L-glutamate
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dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
show the reaction diagram
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L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
show the reaction diagram
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L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
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UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate
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Glu-Leu + H2O = Glu + Leu
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Glu-Leu + H2O = Glu + Leu
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Glu-plasminogen + H2O = Glu + plasmin
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S-(hercyn-2-yl)-gamma-L-glutamyl-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate
show the reaction diagram
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N5-phenyl-L-glutamine + H2O = L-glutamate + aniline
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L-glutamine + H2O = L-glutamate + NH3
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N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine
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N-formyl-L-glutamate + H2O = formate + L-glutamate
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4-(gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate
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5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate
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D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
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D-glutamate = L-glutamate
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ADP + phosphate + beta-citryl-L-glutamate = ATP + citrate + L-glutamate
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ATP + deamido-NAD+ + glutamine = AMP + diphosphate + glutamate + NAD+
show the reaction diagram
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ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate
show the reaction diagram
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ATP + Ni-sirohydrochlorin + L-glutamine + H2O = ADP + phosphate + Ni-sirohydrochlorin a,c-diamide + L-glutamate
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ATP + H2O + L-Glu/out = ADP + phosphate + L-Glu/in
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ATP + H2O + glutamate/out = ADP + phosphate + glutamate/in
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (518 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-acetamido-2-deoxy-alpha-D-glucuronic acid + NAD+ + L-glutamate = UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronic acid + NADH + 2-ketoglutarate
show the reaction diagram
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3-deoxy-alpha-D-manno-octulopyranosonate + O2 + L-Glu = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2
show the reaction diagram
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L-glutamate + O2 = 2-oxopentanedioic acid + NH3
show the reaction diagram
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L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+
show the reaction diagram
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L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH
show the reaction diagram
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L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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L-glutamate + H2O + O2 = 2-oxopentanedioate + NH3 + H2O2
show the reaction diagram
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benzoyl-CoA + L-glutamic acid = CoA + N-benzoyl-L-glutamic acid
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benzoyl-CoA + glutaminic acid = CoA + N-benzoylglutamic acid
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L-arginyl-tRNAArg + L-glutamic acid = tRNAArg + L-Arg-L-Glu
show the reaction diagram
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5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
show the reaction diagram
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O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
show the reaction diagram
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2 S-adenosyl-L-methionine + glutamate = 2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
show the reaction diagram
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L-glutamic acid + KCN = ?
show the reaction diagram
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(3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate = (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate = dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate = 8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
show the reaction diagram
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dTDP-2,6-dideoxy-alpha-D-threo-hexopyranos-4-ulose + L-glutamate = dTDP-4-amino-2,4,6-trideoxy-alpha-D-arabino-hexopyranose + 2-oxoglutarate
show the reaction diagram
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pyruvate + L-glutamate = L-alanine + 2-oxoglutarate
show the reaction diagram
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N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate = N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
show the reaction diagram
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L-glutamate + 4,5-dioxopentanoate = 5-aminolevulinate + 2-oxoglutarate
show the reaction diagram
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L-2-amino-4-oxobutanoate + L-glutamate = L-2,4-diaminobutanoate + 2-oxoglutarate
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3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate = 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate
show the reaction diagram
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glutamic acid + 3-hydroxypyruvate = 2-oxo-1,5-pentandioate + serine
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L-glutamate + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol = 5-amino-2,5-dioxopentanoic acid + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
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L-glutamate + glyoxylate = 2-oxoglutarate + glycine
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L-glutamate + phenylpyruvate = 2-oxoglutarate + L-phenylalanine
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3-methyl-2-oxobutanoate + L-glutamate = L-valine + 2-oxoglutarate
show the reaction diagram
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4-hydroxyphenylglyoxylate + L-glutamate = D-4-hydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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prephenate + L-glutamate = L-arogenate + 2-oxoglutarate
show the reaction diagram
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UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate = UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate = dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate
show the reaction diagram
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UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate = UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine + 2-oxoglutarate
show the reaction diagram
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6'-dehydroparomamine + L-glutamate = neamine + 2-oxoglutarate
show the reaction diagram
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2'-deamino-2'-hydroxyparomamine + L-glutamate = 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate
show the reaction diagram
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dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate = dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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ATP + L-glutamate = ADP + alpha-L-glutamyl phosphate
show the reaction diagram
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acetyl-CoA + L-glutamate = coenzyme A + N-acetyl-L-glutamate
show the reaction diagram
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L-glutamic acid + H2O = ?
show the reaction diagram
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L-Glu = ?
show the reaction diagram
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L-glutamate = 4-aminobutyric acid + CO2
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Glu = 4-Aminobutanoate + CO2
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L-Glu + H2O = ?
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L-glutamate = ?
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L-Glu = D-Glu
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L-glutamate = 3-aminopentanedioate
show the reaction diagram
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ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu
show the reaction diagram
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ATP + L-glutamate + tRNALys = AMP + L-glutamyl-tRNALys + diphosphate
show the reaction diagram
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ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate
show the reaction diagram
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ATP + deamido-NAD+ + Glu = AMP + diphosphate + NAD+ + 2-oxoglutarate
show the reaction diagram
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ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
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ATP + L-glutamate + histamine = products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine
show the reaction diagram
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ATP + L-tyrosine + glutamate = ? + AMP
show the reaction diagram
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L-glutamate + L-cysteine + L-valine + ATP = L-glutamyl-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
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ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
show the reaction diagram
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ATP + [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate + L-glutamate = ADP + phosphate + [lysine-biosynthesis-protein LysW]-C-terminal-gamma-(L-glutam-2-yl)-L-glutamate
show the reaction diagram
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ATP + citrate + L-glutamate = ADP + phosphate + N-citryl-L-glutamate
show the reaction diagram
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ATP + [LysW]-C-terminal-L-glutamate + L-glutamate = ADP + phosphate + [LysW]-C-terminal-gamma-(L-glutamyl)-L-glutamate
show the reaction diagram
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ATP + alpha-tubulin + L-glutamate = L-glutamyl-alpha-tubulin + ADP + phosphate
show the reaction diagram
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ATP + tyramine + L-glutamate = ADP + phosphate + gamma-glutamyltyramine
show the reaction diagram
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glutamate = ?
show the reaction diagram
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ATP + H2O + glutamate/out = ADP + phosphate + glutamate/in
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (852 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glutamate gamma-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+
show the reaction diagram
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methylamine + alpha-ketobutyrate + NADPH = glutamic acid + H2O + NADP+
show the reaction diagram
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L-saccharopine + H2O + O2 = L-2-aminoadipate 6-semialdehyde + L-glutamate + H2O2
show the reaction diagram
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L-ornithine + N-acetyl-L-glutamate = N2-acetyl-L-ornithine + L-glutamate
show the reaction diagram
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(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate
show the reaction diagram
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kanosamine 6-phosphate + 2-oxoglutarate = 3-dehydro-D-glucose 6-phosphate + L-glutamate
show the reaction diagram
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(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
show the reaction diagram
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L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
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L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
show the reaction diagram
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N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
show the reaction diagram
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D-histidine + 2-oxoglutarate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
show the reaction diagram
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