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Literature summary for 6.3.4.2 extracted from
- Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium (2013), PLoS Genet., 9, e1003256.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Drosophila melanogaster |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoophidium | CTP synthase isoform C forms the cytoophidium | Drosophila melanogaster | 97268 | - |
| cytoplasm | CTP synthase isoform B distributes diffusely in the cytoplasm | Drosophila melanogaster | 5737 | - |
| nucleus | CTP synthase isoform A localizes in the nucleus | Drosophila melanogaster | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
x * 70000, SDS-PAGE | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + UTP + L-glutamine | Drosophila melanogaster | - |
ADP + phosphate + CTP + L-glutamate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni2+-IDA resin column chromatography | Drosophila melanogaster |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adult | - |
Drosophila melanogaster | - |
| embryo | - |
Drosophila melanogaster | - |
| larva | - |
Drosophila melanogaster | - |
| pupa | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + UTP + L-glutamine | - |
Drosophila melanogaster | ADP + phosphate + CTP + L-glutamate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 70000, SDS-PAGE | Drosophila melanogaster |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTP synthase | - |
Drosophila melanogaster |
| CTPsyn | - |
Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | mutations disrupting CTP synthase isoform C or isoform A expression results in cytoophidium disassembly | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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