Ligand CTP

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Basic Ligand Information

Molecular Structure
Picture of CTP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H16N3O14P3
CTP
PCDQPRRSZKQHHS-XVFCMESISA-N
Synonyms:
5'-CTP, cytidine triphosphate, D-CTP
Pathway Source
Pathways
MetaCyc
alpha-dystroglycan glycosylation, CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis, CDP-archaeol biosynthesis, CDP-D-arabitol biosynthesis, CDP-D-mannitol biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for CTP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (80 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cob(I)alamin + CTP + H2O + H+ = cytosylcobalamin + diphosphate + phosphate
show the reaction diagram
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CTP + dolichol = CDP + dolichyl phosphate
show the reaction diagram
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CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
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CTP + phytol = CDP + phytyl phosphate
show the reaction diagram
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CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
show the reaction diagram
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
show the reaction diagram
CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor
show the reaction diagram
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CTP + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid = diphosphate + CMP-5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid
show the reaction diagram
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CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate
show the reaction diagram
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CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + 2 H2O = CMP + 2 phosphate
show the reaction diagram
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CTP + H2O = CMP + diphosphate
show the reaction diagram
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CTP + H2O = ?
show the reaction diagram
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CTP = 3',5'-cyclic CMP + diphosphate
show the reaction diagram
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CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide
show the reaction diagram
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CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
show the reaction diagram
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CTP + H2O = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (44 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + CDP = ADP + CTP
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (551 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CTP + formate = dCTP + CO2 + H2O
show the reaction diagram
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CTP + reduced thioredoxin = 2'-dCTP + thioredoxin disulfide + H2O
show the reaction diagram
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5,10-methylenetetrahydrofolate + CTP = dihydrofolate + 5-methylcytidine 5'-triphosphate
show the reaction diagram
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dimethylallyl diphosphate + CTP = ?
show the reaction diagram
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CTP + L-methionine + H2O = S-cytosyl-L-methionine + phosphate + diphosphate
show the reaction diagram
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CTP + D-glucose = CDP + D-glucose 6-phosphate
show the reaction diagram
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CTP + 5-methylthioribose = CDP + 5-methylthioribose 1-phosphate
show the reaction diagram
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CTP + D-fructose 6-phosphate = CDP + beta-D-fructose 2,6-bisphosphate
show the reaction diagram
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CTP + D-fructose 6-phosphate = CDP + D-fructose 1,6-bisphosphate
show the reaction diagram
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CTP + D-gluconate = CDP + 6-phospho-D-gluconate
show the reaction diagram
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CTP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = CDP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
show the reaction diagram
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CTP + D-tagatose 6-phosphate = CDP + D-tagatose 1,6-bisphosphate
show the reaction diagram
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CTP + D-ribose = CDP + D-ribose 5-phosphate
show the reaction diagram
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CTP + L-seryl-tRNASec = CDP + O-phospho-L-seryl-tRNASec
show the reaction diagram
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3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CTP = 3-deoxy-4-O-phosphono-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CDP
show the reaction diagram
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CTP + pantoate = CDP + 4-phosphopantoate
show the reaction diagram
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CTP + 1-deoxy-D-xylulose = CDP + 1-deoxy-D-xylulose 5-phosphate
show the reaction diagram
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CTP + phytol = CDP + phytyl phosphate
show the reaction diagram
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CTP + adenosine = CDP + AMP
show the reaction diagram
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cytidine + CTP = CMP + CDP
show the reaction diagram
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CTP + (2E,6E)-farnesol = CDP + (2E,6E)-farnesyl phosphate
show the reaction diagram
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CTP + adenosine 5-phosphosulfate = CDP + 3'-phosphoadenosine 5'-phosphosulfate
show the reaction diagram
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CTP + riboflavin = CTP + riboflavin 5'-phosphate
show the reaction diagram
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CTP + dihydroxyacetone = CDP + dihydroxyacetone phosphate
show the reaction diagram
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CTP + glycerol = CDP + glycerol 3-phosphate
show the reaction diagram
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CTP + choline = CDP + choline phosphate
show the reaction diagram
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CTP + D-fructose = CDP + D-fructose 6-phosphate
show the reaction diagram
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CTP + 2-dehydro-3-deoxy-D-gluconate = CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
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CTP + 5-hydroxy-2-methylpyrimidine = CDP + 2-methyl-5-phosphopyrimidine
show the reaction diagram
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CTP + 4-methyl-5-(2-hydroxyethyl)thiazole = CDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
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CTP + 6-deoxy-L-galactose = CDP + 6-deoxy-L-galactose 1-phosphate
show the reaction diagram
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CTP + D-arabinose = CDP + D-arabinose 5-phosphate
show the reaction diagram
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CTP + D-fructose 1-phosphate = CDP + D-fructose 1,6-bisphosphate
show the reaction diagram
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CTP + N-acetyl-D-glucosamine = CDP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
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CTP + D-galactose = CDP + alpha-D-galactose 1-phosphate
show the reaction diagram
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CTP + myo-inositol = CDP + myo-inositol 1-phosphate
show the reaction diagram
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CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
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CTP + inosine = CDP + IMP
show the reaction diagram
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CTP + cellobiose = CDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
show the reaction diagram
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CTP + NADH = CDP + NADPH
show the reaction diagram
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CTP + geranylgeraniol = CDP + geranylgeranyl phosphate
show the reaction diagram
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CTP + inosine = CDP + inosine 5'-phosphate
show the reaction diagram
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CTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = CDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
show the reaction diagram
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CTP + acetate = CDP + acetyl phosphate
show the reaction diagram
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CTP + isobutanoate = CDP + isobutanoyl phosphate
show the reaction diagram
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CTP + propanoate = CDP + propanoyl phosphate
show the reaction diagram
CTP + formate = CDP + formyl phosphate
show the reaction diagram
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CTP + AMP = CDP + ADP
show the reaction diagram
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CTP + CMP = CDP + CDP
show the reaction diagram
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CTP + thiamine diphosphate = CDP + thiamine triphosphate
show the reaction diagram
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CTP + trans-farnesyl diphosphate = ?
show the reaction diagram
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CTP + (R,S)-5-phosphomevalonate = CDP + (R,S)-5-diphosphomevalonate
show the reaction diagram
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CTP + CMP = CDP + CDP
show the reaction diagram
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CTP + (2E,6E)-farnesyl phosphate = CDP + (2E,6E)-farnesyl diphosphate
show the reaction diagram
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CTP + dTMP = CDP + dTDP
show the reaction diagram
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CTP + UMP = CDP + UDP
show the reaction diagram
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CTP + D-ribose 5-phosphate = CMP + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
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CTP + thiamine = CMP + thiamine diphosphate
show the reaction diagram
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dATP + CTP = dAMP + cytidine 3'-diphosphate 5'-triphosphate
show the reaction diagram
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CTP + nicotinamide ribonucleotide = diphosphate + nicotinamide cytosine dinucleotide
show the reaction diagram
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CTP + N5-phospho-L-glutamine = diphosphate + N5-(cytidine 5'-diphosphoramidyl)-L-glutamine
show the reaction diagram
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CTP + FMN = diphosphate + flavin cytidine dinucleotide
show the reaction diagram
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CTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + CDP-N-acetyl-alpha-D-glucosamine
show the reaction diagram
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CTP + tobramycin = diphosphate + 2''-adenylyltobramycin
show the reaction diagram
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CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor
show the reaction diagram
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RNA + CTP = RNA+1 + diphosphate
show the reaction diagram
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CTP + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid = diphosphate + CMP-5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid
show the reaction diagram
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CTP + N,N'-diacetyllegionaminic acid = CMP-N,N'-diacetyllegionaminic acid + diphosphate
show the reaction diagram
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3 CTP = ?
show the reaction diagram
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CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate
show the reaction diagram
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CTP + valienol 1-phosphate = diphosphate + CDP-valienol
show the reaction diagram
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CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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glucose + CTP = glucose 6-phosphate + CDP
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + dihydrouracil + H2O = ?
show the reaction diagram
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CTP + H2O = ?
show the reaction diagram
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CTP + H2O = UTP + NH3
show the reaction diagram
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CTP + H2O = ?
show the reaction diagram
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CTP + H2O = CMP + diphosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = ?
show the reaction diagram
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CTP + H2O = CMP + diphosphate
show the reaction diagram
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CTP + H2O = CMP + diphosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + H2O = CDP + phosphate
show the reaction diagram
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CTP + 5-diphosphomevalonate = CDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
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CTP + oxaloacetate = CDP + phosphoenolpyruvate + CO2
show the reaction diagram
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CTP = 3',5'-cyclic CMP + diphosphate
show the reaction diagram
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CTP = 3',5'-cyclic CMP + diphosphate
show the reaction diagram
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CTP + H2O + a dynein associated with a microtubule at position n = CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
show the reaction diagram
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CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide
show the reaction diagram
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CTP + H2O + closed Cl- channel = CDP + phosphate + open Cl- channel
show the reaction diagram
CTP + acetate + CoA = CMP + diphosphate + acetyl-CoA
show the reaction diagram
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CTP + ferulate + CoA = CMP + diphosphate + feruloyl-CoA
show the reaction diagram
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CTP + acetate + CoA = CDP + phosphate + acetyl-CoA
show the reaction diagram
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CTP + butyrate + CoA = CMP + diphosphate + butyryl-CoA
show the reaction diagram
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CTP + acetate + citrate (pro-3S)-lyase = CMP + diphosphate + citrate(pro-3S)-lyase
show the reaction diagram
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CTP + phytanate + CoA = CMP + diphosphate + phytanoyl-CoA
show the reaction diagram
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CTP + o-succinylbenzoate + CoA = CMP + diphosphate + o-succinylbenzoyl-CoA
show the reaction diagram
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CTP + 4-hydroxybenzoate + CoA = CMP + 4-hydroxybenzoyl-CoA + diphosphate
show the reaction diagram
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CTP + phenylacetate + CoA = CMP + diphosphate + phenylacetyl-CoA
show the reaction diagram
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3-hydroxypropanoate + CTP + coenzyme A = 3-hydroxypropanoyl-CoA + CMP + diphosphate
show the reaction diagram
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CTP + oxalate + CoA = CMP + diphosphate + oxalyl-CoA
show the reaction diagram
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CTP + diphthine + ammonia = CDP + phosphate + diphthamide
show the reaction diagram
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CTP + (R)-pantoate + beta-alanine = CMP + diphosphate + (R)-pantothenate
show the reaction diagram
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CTP + L-His + beta-Ala = CMP + phosphate + carnosine
show the reaction diagram
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CTP + D-Ala + membrane-acceptor = CDP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
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CTP + 5,6,7,8-tetrahydropteroyl-Glu + Glu = CDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
show the reaction diagram
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CTP + gamma-Glu-L-Cys + Gly = CDP + phosphate + glutathione
show the reaction diagram
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CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
show the reaction diagram
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CTP + 5-formyltetrahydrofolate = CDP + phosphate + 5,10-methylenetetrahydrofolate
show the reaction diagram
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CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate = CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
show the reaction diagram
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CTP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = CMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]
show the reaction diagram
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CTP + L-Asp + L-Gln = CMP + diphosphate + Asn + Glu
show the reaction diagram
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ATP + CTP = P1-(5'-adenosyl),P4-(5'-cytidyl)tetraphosphate + diphosphate
show the reaction diagram
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CTP + RNA 3'-terminal-phosphate = CMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
show the reaction diagram
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CTP + hydrogenobyrinic acid a,c-diamide + Co2+ = CDP + phosphate + cob(II)yrinic acid a,c-diamide + H+
show the reaction diagram
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CTP + H2O + H+/in = CDP + phosphate + H+/out
show the reaction diagram
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CTP + H2O + Ca2+[side 1] = CDP + phosphate + Ca2+[side 2]
show the reaction diagram
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CTP + H2O + H+/in + K+/out = CDP + phosphate + H+/out + K+/in
show the reaction diagram
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CTP + H2O = ?
show the reaction diagram
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CTP + H2O + phosphate/out = CDP + phosphate + phosphate/in
show the reaction diagram
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CTP + H2O + His/out = CDP + phosphate + His/in
show the reaction diagram
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CTP + H2O + peptide/out = CDP + phosphate + peptide/in
show the reaction diagram
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spermidine/out + CTP + H2O = spermidine/in + CDP + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (105 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CTP + riboflavin = CTP + riboflavin 5'-phosphate
show the reaction diagram
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CDP + phosphoenolpyruvate = CTP + pyruvate
show the reaction diagram
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CDP + phosphoramide = CTP + NH3
show the reaction diagram
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ATP + CMP = ADP + CTP
show the reaction diagram
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diphosphate + CDP-glucose = CTP + alpha-D-glucose 1-phosphate
show the reaction diagram
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Ap4C + H2O = AMP + CTP
show the reaction diagram
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CDP + phosphate + acetyl-CoA = CTP + acetate + CoA
show the reaction diagram
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CDP + phosphate + Na+/out = CTP + H2O + Na+/in
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (32 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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enhances activity
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about 40% activity compared to ATP
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5% of the activity with ATP
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less active than ATP
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less active than ATP
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low activity
can partially substitute for ATP
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activation by nucleotides, most efficient in presence of two different nucleotides
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activation, maintains enzyme in its active conformation at pH 5 and above
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Activator in Enzyme-catalyzed Reactions (98 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at 1mM concentration slight stimulation
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marked stimulation, presence of 50 mM CTP decreases the Km value for ribulose 5-phosphate from 400 to 50 microM
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about half as active as ATP
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10 mM, 340% arsenolytic cleavage activity
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0.67 mM, 2.5fold stimulation
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activation, with ATP as substrate at pH 7
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the activity of the enzyme reaches its maximal activity at a CTP concentration of about 1.4 mM. The maximal activity decreases by 68 and 95% when the concentration of CTP is 5.7 and 11.4 mM, respectively
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activates
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less effective than ATP
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counteracts the inhibition of the cold-labile cytosolic enzyme by ADP
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activation
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activates enzyme from mesenteric lymph nodes
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2 mM, activation to about 110% of control without detergent. Activation to about 200% of control in presence of 1% Triton X-100
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Inhibitor in Enzyme-catalyzed Reactions (549 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 73% and 71% inhibition of liver and spinal cord enzyme respectively
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16% inhibition
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9% inhibition at 25 mM and 21% inhibition at 50 mM
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about half as effective as ATP
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91% inactivation at 1 mM reversible with Mg2+
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5 mM, 86% inhibition of NADP+ reduction
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