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Literature summary for 6.3.4.2 extracted from

  • Williams, J.C.; Kizaki, H.; Weber, G.; Morris, H.P.
    Increased CTP synthetase activity in cancer cells (1978), Nature, 271, 71-73.
    View publication on PubMed
Search for more literature for 6.3.4.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
 GTP
-
 Rattus norvegicus
0.1
-
 L-glutamine pH 7.4 37°C, crude extract Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver in the liver tumours of slow and medium growth rate the specific activity of CTP synthetase is increased 1.8fold to 3.6fold that of normal rat livers, the activity increases from 4.6fold to 11.2fold in rapidly growing hepatomas Rattus norvegicus
-
MH-3924 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UTP + NH4+
-
 Rattus norvegicus ADP + phosphate + CTP
-
 ?
GTP + UTP + NH4+
-
 Rattus norvegicus GDP + phosphate + CTP
-
 ?
L-glutamine + H2O
-
 Rattus norvegicus L-glutamate + NH3
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 9 broad Rattus norvegicus