Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.2 extracted from

  • Noree, C.; Monfort, E.; Shiau, A.K.; Wilhelm, J.E.
    Common regulatory control of CTP synthase enzyme activity and filament formation (2014), Mol. Biol. Cell, 25, 2282-2290 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.4.2

Protein Variants

Protein Variants Comment Organism
C404G inactive Saccharomyces cerevisiae
D70A mutation in the ATP binding site, mutant exhibits approximately twofold increase in the number of cells containing filaments Saccharomyces cerevisiae
E146A mutation in the ATP binding site, mutant exhibits approximately twofold increase in the number of cells containing filaments Saccharomyces cerevisiae
E161K mutation in CTP binding site, filament formation is completely disrupted and the enzyme can only form foci. Mutation decreases the affinity of the enzyme for CTP Saccharomyces cerevisiae
R381M mutation in L11 lid, 3.1fold increase in the number of cells forming filaments Saccharomyces cerevisiae
R381P mutation in L11 lid, 3.1fold increase in the number of cells forming filaments Saccharomyces cerevisiae
S36A mutation in phosphorylation site, causes an approximately twofold decrease in the frequency of filament formation Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P28274
-
-
Saccharomyces cerevisiae ATCC 204508 P28274
-
-

Synonyms

Synonyms Comment Organism
CTP synthase 1
-
 Saccharomyces cerevisiae
URA7
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function destabilization of the active tetrameric form of the enzyme increases filament formation. The sites responsible for feedback inhibition and allos­teric activation control filament length, implying that multiple regions of the enzyme can in­fluence filament structure. Blocking catalysis without disrupting the regulatory sites of the enzyme does not affect filament formation or length Saccharomyces cerevisiae