Disease on EC 6.3.4.2 - CTP synthase (glutamine hydrolysing)

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DISEASE
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Arthritis, Experimental
Acellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model.
Breast Neoplasms
Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53.
Carcinoma
Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine.
Carcinoma, Ehrlich Tumor
CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity.
Purification and properties of CTP synthetase from Ehrlich ascites tumor cells.
Role of GTP in CTP synthetase from Ehrlich ascites tumor cells.
Synthesis of N4-substituted CTP by mammalian CTP synthetase.
The effect of some platinum compounds on the activity of the CTP synthetase of Ehrlich ascites tumor cells: in vitro and in vivo studies.
Carcinoma, Hepatocellular
Biochemical pharmacology of acivicin in rat hepatoma cells.
CTP synthase forms the cytoophidium in human hepatocellular carcinoma.
Increased concentration of CTP synthetase in hepatoma 3924A: immunological evidence.
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Potentiation of antimetabolite action by dibromodulcitol in cell culture.
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.
Uridine and cytidine nucleotide synthesis in renal hypertrophy: biochemical differences in response to the growth stimulus of diabetes and unilateral nephrectomy.
Carcinosarcoma
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Child Nutrition Disorders
Cash transfer programmes in lower-income and middle-income countries: understanding pathways to nutritional change-a realist review protocol.
Colorectal Neoplasms
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC.
Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
ctp synthase (glutamine hydrolysing) deficiency
CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation.
CTP Synthase 1 Deficiency in Successfully Transplanted Siblings with Combined Immune Deficiency and Chronic Active EBV Infection.
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Variable phenotype and discrete alterations of immune phenotypes in CTP synthase 1 deficiency: Report of 2 siblings.
Epstein-Barr Virus Infections
CTP Synthase 1 Deficiency in Successfully Transplanted Siblings with Combined Immune Deficiency and Chronic Active EBV Infection.
Hepatitis B
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Herpes Simplex
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
HIV Infections
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Hypersensitivity
DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection.
Infections
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection.
Escherichia coli nucleoside diphosphate kinase interactions with T4 phage proteins of deoxyribonucleotide synthesis and possible regulatory functions.
Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.
Leukemia
Evidence for transformation-related increase in CTP synthetase activity in situ in human lymphoblastic leukemia.
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase.
The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate.
Leukemia, Myeloid, Acute
Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy.
Leukemia, T-Cell
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Liver Failure
Safety of laparoscopic radical gastrectomy in gastric cancer patients with liver cirrhosis.
Lupus Nephritis
A22: consensus treatment plans for induction therapy in childhood proliferative lupus nephritis-status of use in daily clinical care.
Lymphadenopathy
Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study.
Lymphoma
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Lymphoproliferative Disorders
Cytidine triphosphate synthetase activity in lymphoproliferative disorders.
Malnutrition
Effects of unconditional cash transfers on the outcome of treatment for severe acute malnutrition (SAM): a cluster-randomised trial in the Democratic Republic of the Congo.
Factors Associated With the Risk of Acute Malnutrition Among Children Aged 6 to 36 Months in Households Targeted by an Emergency Cash Transfer Program.
Melanoma
Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma.
Nasopharyngeal Carcinoma
[Cytidine triphosphate synthetase gene expressed in the homogenous nasopharyngeal carcinoma tissue cells]
Neoplasm Metastasis
Identification of critical genes associated with human osteosarcoma metastasis based on integrated gene expression profiling.
Neoplasms
Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissues.
Ara-C metabolism: implications for drug resistance and drug interactions.
Cancer targeting peptides.
Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635.
Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Anti-Inflammatory Drugs and/or with Active Spinal Lesions.
CTP synthase forms the cytoophidium in human hepatocellular carcinoma.
CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity.
Cyclopentenyl cytosine (CPEC): an overview of its in vitro and in vivo activity.
Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy.
Discretization of Gene Expression Data Unmasks Molecular Subgroups Recurring in Different Human Cancer Types.
Ectopic miR-975 induces CTP synthase directed cell proliferation and differentiation in Drosophila melanogaster.
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Identification of a Gene Encoding Slow Skeletal Muscle Troponin T as a Novel Marker for Immortalization of Retinal Pigment Epithelial Cells.
Increased CTP synthetase activity in cancer cells.
Increased cytidine 5'-triphosphate synthetase activity in rat and human tumors.
Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes.
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Penetration of 3-deazauridine into human brain, intracerebral tumor, and cerebrospinal fluid.
Purification and properties of CTP synthetase from Ehrlich ascites tumor cells.
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.
Role of GTP in CTP synthetase from Ehrlich ascites tumor cells.
SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network.
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.
Synthesis of N4-substituted CTP by mammalian CTP synthetase.
The effect of some platinum compounds on the activity of the CTP synthetase of Ehrlich ascites tumor cells: in vitro and in vivo studies.
Uridine and cytidine nucleotide synthesis in renal hypertrophy: biochemical differences in response to the growth stimulus of diabetes and unilateral nephrectomy.
Neuroblastoma
Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma.
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.
Osteosarcoma
Identification of critical genes associated with human osteosarcoma metastasis based on integrated gene expression profiling.
Pancreatic Neoplasms
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Periodontal Diseases
Label-free quantitative proteomic analysis of human periodontal ligament stem cells by high-resolution mass spectrometry.
Poxviridae Infections
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Determination of CTP synthetase activity in crude cell homogenates by a fast and sensitive non-radiochemical assay using anion-exchange high-performance liquid chromatography.
Evidence for transformation-related increase in CTP synthetase activity in situ in human lymphoblastic leukemia.
Increased activity of cytidine Triphosphate synthetase in pediatric acute lymphoblastic leukemia.
Primary Immunodeficiency Diseases
The Challenge of Next Generation Sequencing in a Boy With Severe Mononucleosis and EBV-related Lymphoma.
Scleroderma, Localized
A retrospective study: Impact of consensus treatment plans on systemic therapy of pediatric morphea.
Severe Acute Malnutrition
Effects of unconditional cash transfers on the outcome of treatment for severe acute malnutrition (SAM): a cluster-randomised trial in the Democratic Republic of the Congo.
Smallpox
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Starvation
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Ubiquitination and filamentous structure of cytidine triphosphate synthase.
Stomach Neoplasms
Safety of laparoscopic radical gastrectomy in gastric cancer patients with liver cirrhosis.
Trypanosomiasis, African
Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness.
Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness.
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis.
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness.
Tuberculosis
A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Vascular System Injuries
Smooth muscle-specific drug targets for next-generation drug-eluting stent.