Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | X2JCY2 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
ubiquitination | reversible ubiquitination regulates the dynamic assembly of the filamentous structures of Drosophila CTPsyn. The proto-oncogene Cbl, an E3 ubiquitin ligase, controls CTPsyn filament formation in endocycles. The E3 ligase activity of Cbl is required for CTPsyn filament formation, and Cbl does not affect the protein levels of CTPsyn. In the absence of Cbl or with knockdown of CTPsyn, the progression of the endocycle-associated S phase is impaired. Overexpression of wild-type, but not enzymatically inactive CTPsyn, rescues the endocycle defect in Cbl mutant cells | Drosophila melanogaster |