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Literature summary for 6.3.4.2 extracted from

  • Wang, P.Y.; Lin, W.C.; Tsai, Y.C.; Cheng, M.L.; Lin, Y.H.; Tseng, S.H.; Chakraborty, A.; Pai, L.M.
    Regulation of CTP synthase filament formation during DNA endoreplication in Drosophila (2015), Genetics, 201, 1511-1523 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster X2JCY2
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Posttranslational Modification

Posttranslational Modification Comment Organism
ubiquitination reversible ubiquitination regulates the dynamic assembly of the filamentous structures of Drosophila CTPsyn. The proto-oncogene Cbl, an E3 ubiquitin ligase, controls CTPsyn filament formation in endocycles. The E3 ligase activity of Cbl is required for CTPsyn filament formation, and Cbl does not affect the protein levels of CTPsyn. In the absence of Cbl or with knockdown of CTPsyn, the progression of the endocycle-associated S phase is impaired. Overexpression of wild-type, but not enzymatically inactive CTPsyn, rescues the endocycle defect in Cbl mutant cells Drosophila melanogaster