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EC 1.14.13.113 Details
show Brenda entryEC number
1.14.13.113
Accepted name
FAD-dependent urate hydroxylase
Reaction
urate + NADH + H+ + O2 = 5-hydroxyisourate + NAD+ + H2O
Other name(s)
HpxO enzyme,
FAD-dependent urate oxidase,
urate hydroxylase
Systematic name
urate,NADH:oxygen oxidoreductase (5-hydroxyisourate-forming)
Comment
A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase.
History
created 2010
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
