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EC 1.14.13.95 Details
show Brenda entryEC number
1.14.13.95
Accepted name
7α-hydroxycholest-4-en-3-one 12α-hydroxylase
Reaction
7α-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7α,12α-dihydroxycholest-4-en-3-one + NADP+ + H2O
Other name(s)
7α-hydroxy-4-cholesten-3-one 12α-monooxygenase,
CYP12,
sterol 12α-hydroxylase (ambiguous),
HCO 12α-hydroxylase
Systematic name
7α-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12α-hydroxylating)
Comment
A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH—hemoprotein reductase, which reduced cytochrome b5 at the expense of NADPH. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2].
History
created 2005, deleted 2015
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
