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EC 1.14.13.89 Details
show Brenda entryEC number
1.14.13.89
Accepted name
isoflavone 2′-hydroxylase
Reaction
an isoflavone + NADPH + H+ + O2 = a 2′-hydroxyisoflavone + NADP+ + H2O
Other name(s)
isoflavone 2′-monooxygenase,
CYP81E1,
CYP Ge-3
Systematic name
isoflavone,NADPH:oxygen oxidoreductase (2′-hydroxylating)
CAS registry number
110183-49-8
Comment
A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC 1.14.13.53, 4′-methoxyisoflavone 2′-hydroxylase, has the same reaction but is more specific as it requires a 4′-methoxyisoflavone.
History
created 2005, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
