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EC 1.14.13.165 Details
show Brenda entryEC number
1.14.13.165
Accepted name
nitric-oxide synthase [NAD(P)H]
Reaction
2 L-arginine + 3 NAD(P)H + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NAD(P)+ + 4 H2O (overall reaction);;(1a) 2 L-arginine + 2 NAD(P)H + 2 H+ + 2 O2 = 2 Nω-hydroxy-L-arginine + 2 NAD(P)+ + 2 H2O ;;(1b) 2 Nω-hydroxy-L-arginine + NAD(P)H + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NAD(P)+ + 2 H2O
Other name(s)
nitric oxide synthetase,
NO synthase
Systematic name
L-arginine,NAD(P)H:oxygen oxidoreductase (nitric-oxide-forming)
Comment
Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins [1-2]. The enzyme from the δ-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster [3]. The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39).
History
created 2012, deleted 2017
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
