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EC 1.14.13.41 Details
show Brenda entryEC number
1.14.13.41
Accepted name
tyrosine N-monooxygenase
Reaction
L-tyrosine + 2 O2 + 2 NADPH + 2 H+ = (E)-[4-hydroxyphenylacetaldehyde oxime] + 2 NADP+ + CO2 + 3 H2O (overall reaction);;(1a) L-tyrosine + O2 + NADPH + H+ = N-hydroxy-L-tyrosine + NADP+ + H2O;;(1b) N-hydroxy-L-tyrosine + O2 + NADPH + H+ = N,N-dihydroxy-L-tyrosine + NADP+ + H2O;;(1c) N,N-dihydroxy-L-tyrosine = (E)-[4-hydroxyphenylacetaldehyde oxime] + CO2 + H2O (spontaneous)
Other name(s)
tyrosine N-hydroxylase,
CYP79A1
Systematic name
L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)
CAS registry number
159447-19-5
Comment
A P-450 (heme-thiolate) protein. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase and EC 2.4.1.85, cyanohydrin β-glucosyltransferase. Some 2-(4-hydroxyphenyl)-1-nitroethane is formed as a side product.
History
created 1992, modified 2001, modified 2005, deleted 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
