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EC 1.14.13.121 Details
show Brenda entryEC number
1.14.13.121
Accepted name
premnaspirodiene oxygenase
Reaction
(–)-vetispiradiene + 2 NADPH + 2 H+ + 2 O2 = solavetivone + 2 NADP+ + 3 H2O (overall reaction);;(1a) (–)-vetispiradiene + NADPH + H+ + O2 = solavetivol + NADP+ + H2O;;(1b) solavetivol + NADPH + H+ + O2 = solavetivone + NADP+ + 2 H2O
Other name(s)
HPO,
Hyoscymus muticus premnaspirodiene oxygenase
Systematic name
(–)-vetispiradiene,NADPH:oxygen 2α-oxidoreductase
Comment
A heme-thiolate protein (P-450). The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the α-hydroxy compound, nootkatol, and this is converted into nootkatone. 5-Epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2β-hydroxy derivative which is not further oxidized.
History
created 2011, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
