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EC 1.14.13.53 Details
show Brenda entryEC number
1.14.13.53
Accepted name
4′-methoxyisoflavone 2′-hydroxylase
Reaction
formononetin + NADPH + H+ + O2 = 2′-hydroxyformononetin + NADP+ + H2O
Other name(s)
isoflavone 2′-monooxygenase (ambiguous),
isoflavone 2′-hydroxylase (ambiguous)
Systematic name
formononetin,NADPH:oxygen oxidoreductase (2′-hydroxylating)
CAS registry number
110183-49-8
Comment
A heme-thiolate protein (P-450). Acts on isoflavones with a 4′-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2′-hydroxylase, is less specific and acts on other isoflavones as well as 4′-methoxyisoflavones.
History
created 1992, modified 2005, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
