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EC 1.14.13.50 Details
show Brenda entryEC number
1.14.13.50
Accepted name
pentachlorophenol monooxygenase
Reaction
(1) pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O;;(2) 2,3,5,6-tetrachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP+ + H2O
Other name(s)
pcpB (gene name),
pentachlorophenol dechlorinase,
pentachlorophenol dehalogenase,
pentachlorophenol 4-monooxygenase,
PCP hydroxylase,
pentachlorophenol hydroxylase,
PCB 4-monooxygenase,
PCB4MO
Systematic name
pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)
CAS registry number
136111-57-4
Comment
A flavoprotein (FAD). The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position [2]. If C-4 carries a halogen substituent, reaction 1 is catalysed; if C-4 is unsubstituted, reaction 2 is catalysed.
History
created 1992, modified 2005, modified 2017
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
