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BRENDA support

Information on EC 1.14.13.50 - pentachlorophenol monooxygenase

for references in articles please use BRENDA:EC1.14.13.50

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IUBMB Comments

A flavoprotein (FAD). The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position . If C-4 carries a halogen substituent, reaction 1 is catalysed; if C-4 is unsubstituted, reaction 2 is catalysed.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
pcp hydroxylase, pcp-4-monooxygenase, pentachlorophenol-4-monooxygenase, pentachlorophenol 4-monooxygenase, pcp4mo, pentachlorophenol hydroxylase, pcp 4-monooxygenase, phe4mo, pcp-monooxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,3,5,6-tetrachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP+ + H2O
show the reaction diagram
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pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
show the reaction diagram