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Information on EC 1.14.13.113 - FAD-dependent urate hydroxylase

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IUBMB Comments
A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase.
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The enzyme appears in viruses and cellular organisms
Synonyms
FAD-dependent urate oxidase, flavin adenine dinucleotide-dependent urate oxidase, HpxO, HpxO enzyme, HpyO, urate hydroxylase, XCC0279, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
urate + NADH + H+ + O2 = 5-hydroxyisourate + NAD+ + H2O
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a flavoprotein. The product 5-hydroxyisourate is spontaneously converted to allantoin
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