7.2.2.10: P-type Ca2+ transporter

This is an abbreviated version!
For detailed information about P-type Ca2+ transporter, go to the full flat file.

Word Map on EC 7.2.2.10

7.2.2.10

cardiac

thapsigargin

contractile

ventricular

phospholamban

myocardial

cardiomyocytes

calmodulin

ryanodine

myocytes

na+

myosin

pmcas

atpases

hypertrophy

blocker

cyclopiazonic

inositol

diastolic

caffeine

ca2+-free

fura-2

l-type

vanadate

extrusion

plb

overload

phosphoenzyme

systolic

nifedipine

cpa

excitation-contraction

ouabain

store-operated

1,4,5-trisphosphate

ca2+-binding

calmodulin-dependent

twitch

na+-k+-atpase

slow-twitch

ca2+-sensitive

na,k-atpase

refilling

inotropic

myofibrillar

k+-atpase

fast-twitch

ca2+-induced

medicine

insp3

actin-activated

biotechnology

pharmacology

agriculture

Reaction

Synonyms

ACA, ACA2, ACA8, adenosinetriphosphatase, AfPMR1, AtECA1, ATP-consuming plasma membrane calcium pump, ATP-dependent Ca(2+) pump PMR1, ATP-dependent Ca2+ pump PMR1, ATP-dependent calcium ATPase, Atp2b, ATP6, ATPase 2C1, auto-inhibited Ca2+-ATPase, autoinhibited Ca2+-ATPase, Ca(2+)-transporting ATPase, Ca-ATPase, Ca2+ -ATPase, Ca2+ ATPase, Ca2+ ATPase of sarcoplasmic reticulum, Ca2+ pump, Ca2+ pumping ATPase, Ca2+ transport ATPase, Ca2+ transport ATPase of sarco-endoplasmic reticulum, Ca2+,Mn2+-ATPase, Ca2+-ATPase, Ca2+-ATPase 6, Ca2+-ATPase 8, Ca2+-ATPase pump, Ca2+-ATPase, isoform 10, Ca2+-ATPase, isoform 11, Ca2+-ATPase, isoform 12, Ca2+-ATPase, isoform 13, Ca2+-dependent ATPase, Ca2+-Mg2+-ATPase, Ca2+-pumping ATPase, Ca2+-transporting ATPase, Ca2+/Mn2+ ATPase pump, Ca2+/Mn2+ P-type ATPase, Ca2+/Mn2+-ATPase 1, Ca2+/Mn2+-ATPase 2, calcium and manganese transporting ATPase, calcium pump, calcium-dependent ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, calcium-transporting ATPase type 2C member 1, CePMR-1, ChkSERCA3, Cod1 protein, Cod1p, EC 3.6.1.3, EC 3.6.1.38, EC 3.6.3.8, eCA, ECA1, ECA2, ECA3, ECA4, endomembrane Ca2+-ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase, endosomal Ca2+/Mn2+ pump, ER-type Ca2+-ATPase, Golgi Ca2+-ATPase, HUSSY-28, LCA, LCA1, Mn2+-transporting P-type ATPase, More, P-type ATPase, P-type Ca2+-ATPase, P-type Ca2+/Mn2+ ATPase, P-type Ca2+/Mn2+-ATPase, P-type calcium ATPase, P2A Ca2+ pump, P2A Ca2+-ATPase, P2B Ca2+ pump, P2B Ca2+-ATPase, PCA1, PCMA4b, PfATP6, phosphatase, adenosine tri, plasma membrane ATPase related 1, plasma membrane Ca-ATPase, plasma membrane Ca2+, plasma membrane Ca2+ ATPase, plasma membrane Ca2+ pump 4xb, plasma membrane Ca2+-ATPase, plasma membrane Ca2+-ATPase 1, plasma membrane Ca2+-ATPase 2, plasma membrane Ca2+-ATPase 4, plasma membrane Ca2+-ATPase 4xb, plasma membrane Ca2+-ATPase isoform 4, plasma membrane Ca2+-ATPase isoform ACA8, plasma membrane Ca2+-ATPase-4, plasma membrane Ca2+-pump, plasma membrane calcium ATPase, plasma membrane calcium ATPase 2 calcium pump, plasma membrane calcium pump, plasma-membrane Ca2+-ATPase, plasmalemmal Ca2+ pump isoform 2, plasmalemmal Ca2+-ATPase, PM Ca2+-ATPase, PMCA, PMCA pump, PMCA1, PMCA2, PMCA3, PMCA4, PMCA4a, PMCA4b, PMR1, PMR1-like calcium ATPase, Pmr1p, sarco(endo)plasmic reticulum ATPase, sarco(endo)plasmic reticulum Ca2+ ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase 2b, sarco(endo)plasmic reticulum calcium ATPase, sarco-endoplasmic reticulum Ca2+ ATPase, sarco-endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum Ca2+ ATPase, sarco/endoplasmic reticulum Ca2+ ATPase 3, sarco/endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum calcium ATPase, sarcoendoplasmic reticulum Ca2+ ATPase6, sarcoendoplasmic reticulum Ca2+-ATPase, sarcoendoplasmic reticulum Ca2+-ATPase isoform 1a, sarcoendoplasmic reticulum calcium ATPase, sarcolemmal Ca2+-ATPase, sarcoplasmic reticulum (Ca2+)-ATPase, sarcoplasmic reticulum ATPase, sarcoplasmic reticulum Ca(2+)-ATPase, sarcoplasmic reticulum Ca-ATPase, sarcoplasmic reticulum Ca2+ ATPase, sarcoplasmic reticulum Ca2+ ATPase 1, sarcoplasmic reticulum Ca2+ ATPase 2, sarcoplasmic reticulum Ca2+ ATPase pump, sarcoplasmic reticulum Ca2+-ATPase, sarcoplasmic reticulum Ca2+-ATPase 1, sarcoplasmic reticulum Ca2+-pump ATPase, sarcoplasmic reticulum calcium ATPase, sarcoplasmic reticulum calcium pump, sarcoplasmic reticulum calcium-dependent adenosine triphosphatase, sarcoplasmic-endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum calcium ATPase, secretory pathway Ca-ATPase, Secretory pathway Ca2+ transporting ATPase, secretory pathway Ca2+-ATPase, secretory pathway Ca2+-ATPase 1, secretory pathway Ca2+/Mn2+-ATPase, SERCA, SERCA 1, SERCA 2, SERCA 3, SERCA pump, SERCA-1, SERCA-like calcium ATPase, SERCA1, SERCA1a, SERCA1b, SERCA2, SERCA2a, SERCA2b, SERCA3, SERCA3a, SERCA3b, SERCA3c, SERCA3d, SERCA3f, SMA1, SPCA, SPCA1, SPCA2, Spf1, SR Ca-ATPase, SR Ca2+-ATPase, Vacuolar Ca2+-ATPase

ECTree

7 Translocases

7.2 Catalysing the translocation of inorganic cations

7.2.2 Linked to the hydrolysis of a nucleoside triphosphate

7.2.2.10 P-type Ca2+ transporter

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Results	in table
62	Activating Compound
32778	AA Sequence
9	Application
1	CAS Registry Number
52	Cloned(Commentary)
5	Cofactor
10	Crystallization (Commentary)
4994	Disease/ Diagnostics
17	Expression
59	General Information
3	General Stability
60	IC50 Value
360	Inhibitors
11	Ki Value [mM]
34	KM Value [mM]
221	Localization
119	Metals/Ions
31	Molecular Weight [Da]
114	Natural Substrates/ Products (Substrates)
208	Organism
1	Oxidation Stability
14	PDB ID
25	pH Optimum
7	pH Range
4	pH Stability
1	pI Value
16	Posttranslational Modification
82	Protein Variants
45	Purification (Commentary)
12	Reaction
4	Reaction Type
192	Reference
4	Renatured (Commentary)
327	Source Tissue
18	Specific Activity [micromol/min/mg]
4	Storage Stability
228	Substrates and Products (Substrate)
44	Subunits
436	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
19	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 7.2.2.10 - P-type Ca2+ transporter

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1,2-dichlorobenzene

Oryctolagus cuniculus

concentrations of 0.05-0.2 mM of 1,2-dichlorobenzene stimulate the hydrolytic activity of the enzyme in a medium-containing Ca2+-ionophore

A-23187

ATP

Ca2+

Calcineurin

Saccharomyces cerevisiae

Pmr1p is positively controlled by the calmodulin and calcineurin complex in the presence of an elevated Ca2+ level

697976

calcium-bound calmodulin

Arabidopsis thaliana

in the resting state, the plant plasma-membrane Ca2+-ATPase is autoinhibited by binding of its N-terminal tail to two major intracellular loops. Activation requires the binding of calcium-bound calmodulin to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain

Calmodulin

calmodulin-like 36

CML36 interacts directly with the regulative N terminus of the Arabidopsis plasma membrane Ca2+-ATPase isoform 8 which stimulates the enzyme activity

751094

calpain

2 entries

G-actin

Homo sapiens

when purified enzyme is incubated with increasing concentrations of G-actin, an increase in the rate of ATP hydrolysis is observed

734224

HSP70

Rattus norvegicus

chaperone system can bind to enzyme and, depending on the severity of heat stress, protect the enzyme's function by stabilizing the nucleotide binding domain

656262

luteolin

Rattus norvegicus

750281

Mg2+

Lamellidens marginalis

684657

N,N-dimethylalkylamine N-oxide

Oryctolagus cuniculus

slight stimulation at low concentrations, inhibition at higher concentrations

210496

N-alkyl-N,N-dimethylamine-N-oxide

Oryctolagus cuniculus

CnNO with n = 10-20, stimulate at low concentrations and inhibit at high concentrations dependent on the compound alkyl chain length, overview

670493

phosphatidylinositol 4-monophosphate

Arabidopsis thaliana

433% stimulation of activity at 1 mM

700250

phosphatidylinositol bisphosphate

2 entries

phosphatidylserine

2 entries

potassium oxalate

Oryctolagus cuniculus

Ca2+ uptake is supported by potassium oxalate

750181

sperm-activating and attracting factor

Trypsin

valinomycin

Canis lupus familiaris

the rate of Ca2+ uptake is stimulated by a inside-negative potential induced in the presence of valinomycin

210479

additional information

9 entries