7.2.2.10: P-type Ca2+ transporter

This is an abbreviated version!
For detailed information about P-type Ca2+ transporter, go to the full flat file.

Reaction

Synonyms

ACA, ACA2, ACA8, adenosinetriphosphatase, AfPMR1, AtECA1, ATP-consuming plasma membrane calcium pump, ATP-dependent Ca(2+) pump PMR1, ATP-dependent Ca2+ pump PMR1, ATP-dependent calcium ATPase, Atp2b, ATP6, ATPase 2C1, auto-inhibited Ca2+-ATPase, autoinhibited Ca2+-ATPase, Ca(2+)-transporting ATPase, Ca-ATPase, Ca2+ -ATPase, Ca2+ ATPase, Ca2+ ATPase of sarcoplasmic reticulum, Ca2+ pump, Ca2+ pumping ATPase, Ca2+ transport ATPase, Ca2+ transport ATPase of sarco-endoplasmic reticulum, Ca2+,Mn2+-ATPase, Ca2+-ATPase, Ca2+-ATPase 6, Ca2+-ATPase 8, Ca2+-ATPase pump, Ca2+-ATPase, isoform 10, Ca2+-ATPase, isoform 11, Ca2+-ATPase, isoform 12, Ca2+-ATPase, isoform 13, Ca2+-dependent ATPase, Ca2+-Mg2+-ATPase, Ca2+-pumping ATPase, Ca2+-transporting ATPase, Ca2+/Mn2+ ATPase pump, Ca2+/Mn2+ P-type ATPase, Ca2+/Mn2+-ATPase 1, Ca2+/Mn2+-ATPase 2, calcium and manganese transporting ATPase, calcium pump, calcium-dependent ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, calcium-transporting ATPase type 2C member 1, CePMR-1, ChkSERCA3, Cod1 protein, Cod1p, EC 3.6.1.3, EC 3.6.1.38, EC 3.6.3.8, eCA, ECA1, ECA2, ECA3, ECA4, endomembrane Ca2+-ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase, endosomal Ca2+/Mn2+ pump, ER-type Ca2+-ATPase, Golgi Ca2+-ATPase, HUSSY-28, LCA, LCA1, Mn2+-transporting P-type ATPase, More, P-type ATPase, P-type Ca2+-ATPase, P-type Ca2+/Mn2+ ATPase, P-type Ca2+/Mn2+-ATPase, P-type calcium ATPase, P2A Ca2+ pump, P2A Ca2+-ATPase, P2B Ca2+ pump, P2B Ca2+-ATPase, PCA1, PCMA4b, PfATP6, phosphatase, adenosine tri, plasma membrane ATPase related 1, plasma membrane Ca-ATPase, plasma membrane Ca2+, plasma membrane Ca2+ ATPase, plasma membrane Ca2+ pump 4xb, plasma membrane Ca2+-ATPase, plasma membrane Ca2+-ATPase 1, plasma membrane Ca2+-ATPase 2, plasma membrane Ca2+-ATPase 4, plasma membrane Ca2+-ATPase 4xb, plasma membrane Ca2+-ATPase isoform 4, plasma membrane Ca2+-ATPase isoform ACA8, plasma membrane Ca2+-ATPase-4, plasma membrane Ca2+-pump, plasma membrane calcium ATPase, plasma membrane calcium ATPase 2 calcium pump, plasma membrane calcium pump, plasma-membrane Ca2+-ATPase, plasmalemmal Ca2+ pump isoform 2, plasmalemmal Ca2+-ATPase, PM Ca2+-ATPase, PMCA, PMCA pump, PMCA1, PMCA2, PMCA3, PMCA4, PMCA4a, PMCA4b, PMR1, PMR1-like calcium ATPase, Pmr1p, sarco(endo)plasmic reticulum ATPase, sarco(endo)plasmic reticulum Ca2+ ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase 2b, sarco(endo)plasmic reticulum calcium ATPase, sarco-endoplasmic reticulum Ca2+ ATPase, sarco-endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum Ca2+ ATPase, sarco/endoplasmic reticulum Ca2+ ATPase 3, sarco/endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum calcium ATPase, sarcoendoplasmic reticulum Ca2+ ATPase6, sarcoendoplasmic reticulum Ca2+-ATPase, sarcoendoplasmic reticulum Ca2+-ATPase isoform 1a, sarcoendoplasmic reticulum calcium ATPase, sarcolemmal Ca2+-ATPase, sarcoplasmic reticulum (Ca2+)-ATPase, sarcoplasmic reticulum ATPase, sarcoplasmic reticulum Ca(2+)-ATPase, sarcoplasmic reticulum Ca-ATPase, sarcoplasmic reticulum Ca2+ ATPase, sarcoplasmic reticulum Ca2+ ATPase 1, sarcoplasmic reticulum Ca2+ ATPase 2, sarcoplasmic reticulum Ca2+ ATPase pump, sarcoplasmic reticulum Ca2+-ATPase, sarcoplasmic reticulum Ca2+-ATPase 1, sarcoplasmic reticulum Ca2+-pump ATPase, sarcoplasmic reticulum calcium ATPase, sarcoplasmic reticulum calcium pump, sarcoplasmic reticulum calcium-dependent adenosine triphosphatase, sarcoplasmic-endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum calcium ATPase, secretory pathway Ca-ATPase, Secretory pathway Ca2+ transporting ATPase, secretory pathway Ca2+-ATPase, secretory pathway Ca2+-ATPase 1, secretory pathway Ca2+/Mn2+-ATPase, SERCA, SERCA 1, SERCA 2, SERCA 3, SERCA pump, SERCA-1, SERCA-like calcium ATPase, SERCA1, SERCA1a, SERCA1b, SERCA2, SERCA2a, SERCA2b, SERCA3, SERCA3a, SERCA3b, SERCA3c, SERCA3d, SERCA3f, SMA1, SPCA, SPCA1, SPCA2, Spf1, SR Ca-ATPase, SR Ca2+-ATPase, Vacuolar Ca2+-ATPase

ECTree

     7 Translocases

         7.2 Catalysing the translocation of inorganic cations

             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate

                7.2.2.10 P-type Ca2+ transporter

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Results	in table
62	Activating Compound
32778	AA Sequence
9	Application
1	CAS Registry Number
52	Cloned(Commentary)
5	Cofactor
10	Crystallization (Commentary)
4994	Disease/ Diagnostics
17	Expression
59	General Information
3	General Stability
60	IC50 Value
360	Inhibitors
11	Ki Value [mM]
34	KM Value [mM]
221	Localization
119	Metals/Ions
31	Molecular Weight [Da]
114	Natural Substrates/ Products (Substrates)
208	Organism
1	Oxidation Stability
14	PDB ID
25	pH Optimum
7	pH Range
4	pH Stability
1	pI Value
16	Posttranslational Modification
82	Protein Variants
45	Purification (Commentary)
12	Reaction
4	Reaction Type
192	Reference
4	Renatured (Commentary)
327	Source Tissue
18	Specific Activity [micromol/min/mg]
4	Storage Stability
228	Substrates and Products (Substrate)
44	Subunits
436	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
19	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 7.2.2.10 - P-type Ca2+ transporter

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.007

(2Z)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.152

(4-chlorophenyl)(pyridin-2-yl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanol

Oryctolagus cuniculus

P04191

in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.022 - 0.029

(4-chlorophenyl)[4-([[3-(4-[3-[(7-chloroquinolin-4-yl)amino]propyl]piperazin-1-yl)propyl]amino]methyl)phenyl]methanone

2 entries

0.0013

(N-((3-chlorophenyl)(4-(pyrrolidin-1-yl)methyl)phenyl)methyl)-7-chloro-4-aminoquinoline

Oryctolagus cuniculus

P04191

in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.015

1,1'-methanediyldinaphthalen-2-ol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0273

1-(naphthalen-1-ylmethyl)naphthalen-2-ol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.032

1-[(4-chlorophenyl)(phenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1H-1,2,4-triazole

Oryctolagus cuniculus

P04191

in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.057

1-[(4-chlorophenyl)(phenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1H-imidazole

Oryctolagus cuniculus

P04191

in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.0213

2,2',2''-methanetriyltris(4-tert-butylphenol)

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0118

2,2'-methanediylbis(4-tert-butylphenol)

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.001

2,3-bis[(2-hydroxyethyl)sulfanyl]naphthalene-1,4-dione

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0338

2,4-di-tert-butyl-6-(1-phenylethyl)phenol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0353

2,4-di-tert-butyl-6-[1-(4-methoxyphenyl)ethyl]phenol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0188

2,5-bis(2-methylpropyl)phenol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0094

2,5-bis(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.065

2,5-di(tert-butyl)-1,4-benzohydroquinone

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0454

2,6-di-tert-butyl-4-[1-(4-methoxyphenyl)ethyl]phenol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0202

2-(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0115

2-cyclooctylbenzene-1,4-diol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.001

2-phenyl-1,2-benzoselenazol-3(2H)-one

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0031

2-[(cyclopropylcarbonyl)amino]-4,5-dimethylthiophene-3-carboxamide

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0497

3-(1,1-diphenylethyl)cyclopentanol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0393

4,4'-butane-2,2-diylbis(2-methylphenol)

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0283

4,4'-butane-2,3-diyldiphenol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0195

4,4'-propane-2,2-diylbis(2,6-dimethylphenol)

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0238

4,5-dibenzylbenzene-1,2-diol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0011

4,5-dimethyl-2-([[5-methyl-2-(propan-2-yl)phenoxy]acetyl]amino)thiophene-3-carboxamide

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0172

4-(7-methyloctyl)phenol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.003

5-chloro-N-(3,5-dimethoxyphenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-methoxybenzamide

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0085

6-amino-2-(hex-1-yn-1-yl)-9H-purin-9-yl-beta-D-N-ethylribofuranoic amide

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0281

6-tert-butyl-2,3-dihydro-1H-inden-5-ol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.0025

amyloid beta-peptide 25-35

Sus scrofa

P23220

-

697858

-

0.00229

biphenyl-2,5-diol

Oryctolagus cuniculus

P04191

In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)

696744

0.04

bis(maltolato)oxovanadium(IV)

Oryctolagus cuniculus

-

in 25 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 0.05 mM CaCl2, at 25°C

698270

0.325

bis(N-hydroxylamidoiminodiacetato)vanadium(IV)

Oryctolagus cuniculus

-

in 25 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 0.05 mM CaCl2, at 25°C

698270

0.085 - 0.42

chlorpromazine

3 entries

35

clotrimazole

Oryctolagus cuniculus

P04191

IC50 about 0.035 mM, in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.00016 - 0.0004

cyclopiazonic acid

2 entries

0.0036

eosin

Solanum lycopersicum

Q42883

in 1 mM EGTA, 130 mM NaCl, 3 mM MgCl2, at 37°C

695867

0.0012

methyl [(4-tert-butylbenzoyl)amino]acetate

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0008

N-((3-chlorophenyl)(4-((4-(7-chloroquinolin-4-yl)piperazin-1-yl)methyl)phenyl)methyl)-7-chloro-4-aminoquinoline

Oryctolagus cuniculus

P04191

in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.0004

palytoxin

Oryctolagus cuniculus

-

in 20 mM MOPS, pH 7.0, 80 mM KC1, 5 mM MgCl2, 0.5 mM EGTA, 0.55 mM CaC12, at 25°C

695863

0.025

pyridine-2,6-dicarboxylatodioxovanadium

Oryctolagus cuniculus

-

in 25 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 0.05 mM CaCl2, at 25°C

698270

0.023

rutin 4'''-O-arachidonate

Oryctolagus cuniculus

P04191

at 37°C and pH 7.4

734516

0.05

rutin 4'''-O-erucate

Oryctolagus cuniculus

P04191

at 37°C and pH 7.4

734516

0.025

rutin 4'''-O-linoleate

Oryctolagus cuniculus

P04191

at 37°C and pH 7.4

734516

0.062

rutin 4'''-O-linolenate

Oryctolagus cuniculus

P04191

at 37°C and pH 7.4

734516

0.05

rutin 4'''-O-oleate

Oryctolagus cuniculus

P04191

at 37°C and pH 7.4

734516

0.035

rutin 4'''-O-stearate

Oryctolagus cuniculus

P04191

at 37°C and pH 7.4

734516

0.064

rutin palmitate

Oryctolagus cuniculus

P04191

at 37°C and pH 7.4

734516

0.000635 - 0.15

thapsigargin

3 entries

0.0057 - 0.08

vanadate

2 entries

0.127

[(dihydroindenyl)oxy]acetic acid

Oryctolagus cuniculus

-

-

686551

0.022

(4-chlorophenyl)[4-([[3-(4-[3-[(7-chloroquinolin-4-yl)amino]propyl]piperazin-1-yl)propyl]amino]methyl)phenyl]methanone

Oryctolagus cuniculus

P04191

in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.029

(4-chlorophenyl)[4-([[3-(4-[3-[(7-chloroquinolin-4-yl)amino]propyl]piperazin-1-yl)propyl]amino]methyl)phenyl]methanone

Oryctolagus cuniculus

P04191

in 20 mM MOPS, pH 6.8, 80 mM KCl, 3 mM MgCl2, 0.002 mM A23187, 5 mM sodium azide, and 2 mM EGTA, or 0.2 mM EGTA plus 0.2 mM CaCl2, at 37°C

719980

0.085

chlorpromazine

Homo sapiens

-

trypsin-activated enzyme, at pH 7.2 and 25°C

750998

0.15

chlorpromazine

Homo sapiens

-

native enzyme in the presence of 0.002 mg/ml calmodulin, at pH 7.2 and 25°C

750998

0.42

chlorpromazine

Homo sapiens

-

native enzyme, at pH 7.2 and 25°C

750998

0.00016

cyclopiazonic acid

Solanum lycopersicum

Q42883

in 1 mM EGTA, 130 mM NaCl, 3 mM MgCl2, at 37°C

695867

0.0004

cyclopiazonic acid

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.000635

thapsigargin

Solanum lycopersicum

Q42883

recombinant enzyme expressed in Saccharomyces cerevisiae strain HI227, in 1 mM EGTA, 130 mM NaCl, 3 mM MgCl2, at 37°C

695867

0.00095

thapsigargin

Solanum lycopersicum

Q42883

recombinant enzyme expressed in Saccharomyces cerevisiae strain K616, in 1 mM EGTA, 130 mM NaCl, 3 mM MgCl2, at 37°C

695867

0.15

thapsigargin

Plasmodium falciparum

-

at pH 7.5 and 25°C

733830

0.0057

vanadate

Solanum lycopersicum

Q42883

in 1 mM EGTA, 130 mM NaCl, 3 mM MgCl2, at 37°C

695867

0.08

vanadate

Oryctolagus cuniculus

-

in 25 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 0.05 mM CaCl2, at 25°C

698270