7.2.2.10: P-type Ca2+ transporter This is an abbreviated version! For detailed information about P-type Ca2+ transporter, go to the full flat file .
Reaction
ATP +
H2O +
Ca2+[side 1] =
ADP +
phosphate +
Ca2+[side 2]
Synonyms ACA, ACA2, ACA8, adenosinetriphosphatase, AfPMR1, AtECA1, ATP-consuming plasma membrane calcium pump, ATP-dependent Ca(2+) pump PMR1, ATP-dependent Ca2+ pump PMR1, ATP-dependent calcium ATPase, Atp2b, ATP6, ATPase 2C1, auto-inhibited Ca2+-ATPase, autoinhibited Ca2+-ATPase, Ca(2+)-transporting ATPase, Ca-ATPase, Ca2+ -ATPase, Ca2+ ATPase, Ca2+ ATPase of sarcoplasmic reticulum, Ca2+ pump, Ca2+ pumping ATPase, Ca2+ transport ATPase, Ca2+ transport ATPase of sarco-endoplasmic reticulum, Ca2+,Mn2+-ATPase, Ca2+-ATPase, Ca2+-ATPase 6, Ca2+-ATPase 8, Ca2+-ATPase pump, Ca2+-ATPase, isoform 10, Ca2+-ATPase, isoform 11, Ca2+-ATPase, isoform 12, Ca2+-ATPase, isoform 13, Ca2+-dependent ATPase, Ca2+-Mg2+-ATPase, Ca2+-pumping ATPase, Ca2+-transporting ATPase, Ca2+/Mn2+ ATPase pump, Ca2+/Mn2+ P-type ATPase, Ca2+/Mn2+-ATPase 1, Ca2+/Mn2+-ATPase 2, calcium and manganese transporting ATPase, calcium pump, calcium-dependent ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, calcium-transporting ATPase type 2C member 1, CePMR-1, ChkSERCA3, Cod1 protein, Cod1p, EC 3.6.1.3, EC 3.6.1.38, EC 3.6.3.8, eCA, ECA1, ECA2, ECA3, ECA4, endomembrane Ca2+-ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase, endosomal Ca2+/Mn2+ pump, ER-type Ca2+-ATPase, Golgi Ca2+-ATPase, HUSSY-28, LCA, LCA1, Mn2+-transporting P-type ATPase, More, P-type ATPase, P-type Ca2+-ATPase, P-type Ca2+/Mn2+ ATPase, P-type Ca2+/Mn2+-ATPase, P-type calcium ATPase, P2A Ca2+ pump, P2A Ca2+-ATPase, P2B Ca2+ pump, P2B Ca2+-ATPase, PCA1, PCMA4b, PfATP6, phosphatase, adenosine tri, plasma membrane ATPase related 1, plasma membrane Ca-ATPase, plasma membrane Ca2+, plasma membrane Ca2+ ATPase, plasma membrane Ca2+ pump 4xb, plasma membrane Ca2+-ATPase, plasma membrane Ca2+-ATPase 1, plasma membrane Ca2+-ATPase 2, plasma membrane Ca2+-ATPase 4, plasma membrane Ca2+-ATPase 4xb, plasma membrane Ca2+-ATPase isoform 4, plasma membrane Ca2+-ATPase isoform ACA8, plasma membrane Ca2+-ATPase-4, plasma membrane Ca2+-pump, plasma membrane calcium ATPase, plasma membrane calcium ATPase 2 calcium pump, plasma membrane calcium pump, plasma-membrane Ca2+-ATPase, plasmalemmal Ca2+ pump isoform 2, plasmalemmal Ca2+-ATPase, PM Ca2+-ATPase, PMCA, PMCA pump, PMCA1, PMCA2, PMCA3, PMCA4, PMCA4a, PMCA4b, PMR1, PMR1-like calcium ATPase, Pmr1p, sarco(endo)plasmic reticulum ATPase, sarco(endo)plasmic reticulum Ca2+ ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase 2b, sarco(endo)plasmic reticulum calcium ATPase, sarco-endoplasmic reticulum Ca2+ ATPase, sarco-endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum Ca2+ ATPase, sarco/endoplasmic reticulum Ca2+ ATPase 3, sarco/endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum calcium ATPase, sarcoendoplasmic reticulum Ca2+ ATPase6, sarcoendoplasmic reticulum Ca2+-ATPase, sarcoendoplasmic reticulum Ca2+-ATPase isoform 1a, sarcoendoplasmic reticulum calcium ATPase, sarcolemmal Ca2+-ATPase, sarcoplasmic reticulum (Ca2+)-ATPase, sarcoplasmic reticulum ATPase, sarcoplasmic reticulum Ca(2+)-ATPase, sarcoplasmic reticulum Ca-ATPase, sarcoplasmic reticulum Ca2+ ATPase, sarcoplasmic reticulum Ca2+ ATPase 1, sarcoplasmic reticulum Ca2+ ATPase 2, sarcoplasmic reticulum Ca2+ ATPase pump, sarcoplasmic reticulum Ca2+-ATPase, sarcoplasmic reticulum Ca2+-ATPase 1, sarcoplasmic reticulum Ca2+-pump ATPase, sarcoplasmic reticulum calcium ATPase, sarcoplasmic reticulum calcium pump, sarcoplasmic reticulum calcium-dependent adenosine triphosphatase, sarcoplasmic-endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum calcium ATPase, secretory pathway Ca-ATPase, Secretory pathway Ca2+ transporting ATPase, secretory pathway Ca2+-ATPase, secretory pathway Ca2+-ATPase 1, secretory pathway Ca2+/Mn2+-ATPase, SERCA, SERCA 1, SERCA 2, SERCA 3, SERCA pump, SERCA-1, SERCA-like calcium ATPase, SERCA1, SERCA1a, SERCA1b, SERCA2, SERCA2a, SERCA2b, SERCA3, SERCA3a, SERCA3b, SERCA3c, SERCA3d, SERCA3f, SMA1, SPCA, SPCA1, SPCA2, Spf1, SR Ca-ATPase, SR Ca2+-ATPase, Vacuolar Ca2+-ATPase
ECTree
Source Tissue
Source Tissue on EC 7.2.2.10 - P-type Ca2+ transporter
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
CF-41o cell, CF-45o cell
brenda
expression and activity during molting cycle, overview
brenda
-
atrial monocyte
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
strongest expression of isoform SPCA2
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
apical membrane of the epididymal epithelium
brenda
isoform SERCA 1
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
highest expression
brenda
-
-
brenda
-
-
brenda
-
masseter and medial pterygoid
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
primary, isozyme SPCA2 shows a highly punctate distribution
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
only isoform SPCA1
brenda
-
isoform ACA9
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
isoform SERCA 2
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
isoform PMCA 4 is more abundant in the cerebrum than in the cerebellum
brenda
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
only isoform SPCA1
brenda
-
-
brenda
-
exclusively located in
brenda
-
exclusively located in
-
brenda
-
-
brenda
predominant expression of splice variant PMCA4a
brenda
-
-
brenda
-
-
brenda
isoform SERCA 2
brenda
isoform SERCA 3
brenda
-
synaptosomes
brenda
-
brenda
-
-
brenda
-
isozyme SPCA2
brenda
PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine
brenda
the PMCA2 pump is a brain isoform
brenda
the PMCA3 pump is expressed in brain
brenda
PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine. The PMCA3 and PMCA4 pumps are expressed in brain, the PMCA2 pump is a brain isoform.
brenda
predominant expression of splice variant PMCA4e
brenda
-
-
brenda
-
synaptosomes
brenda
-
-
brenda
-
-
brenda
-
-
brenda
expression and activity during molting cycle, overview
brenda
-
-
brenda
-
-
brenda
PMCA2 is highly expressed in cerebellar Purkinje cells
brenda
PMCA2 is highly expressed in cerebellar Purkinje cells
brenda
-
-
brenda
-
-
brenda
isoform PMCA 2 is more abundant in the cerebellum than in the cerebrum
brenda
-
-
brenda
-
-
brenda
-
brenda
-
strongest expression of isoform SPCA2
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
isoform 4b
brenda
the PMCA4 pump is expressed in erythrocyte
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
expression and activity during molting cycle, overview
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
PMCA2 is expressed at a lower level in the heart
brenda
-
-
brenda
-
-
brenda
-
methods to employ tissue homogenates to study sarcoplasmatic reticulum Ca2+ transport function in individual mouse hearts
brenda
the PMCA4 pump is expressed in heart, PMCA2 is expressed at a lower level in the heart
brenda
predominant expression of splice variant PMCA4e
brenda
Pigeon
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
Homarus sp.
-
-
brenda
PMCA2 is highly expressed in the hair cells of the inner ear
brenda
PMCA2 is highly expressed in the hair cells of the inner ear
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine
brenda
-
-
brenda
PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine. The PMCA4 pump is expressed in intestine.
brenda
-
and nonpolarized cells, isozyme SPCA1
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
the PMCA4 pump is expressed in kidney
brenda
predominant expression of splice variant PMCA4e
brenda
expression and activity during molting cycle, overview
brenda
-
-
brenda
-
-
brenda
-
lowest protein content and activity in kidney
brenda
-
brenda
low expression
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
only isoform SPCA1
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine
brenda
PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
the brain isoform PMCA2 pump is also expressed in the lactating mammary glands
brenda
-
SPCA2 is expressed predominately in luminal epithelial cells of the mouse mammary gland during lactation with noexpression in cells outside the acini, SPCA1 is found in all cell types of the tissue section including myoepithelial and stromal cells, PMCA2 expression appears confined to the alveolus, whereas non-acinar cells do not express PMCA2, PMCA1 is ubiquitously expressed in the mammary gland sections with expression outside the acini
brenda
the brain isoform PMCA2 pump is also expressed in the lactating mammary glands
brenda
-
strongest expression of isoform PMCA1 in the prelactating mammary gland
brenda
-
brenda
-
brenda
-
-
brenda
-
isoform SERCA1b is only expressed in prematured infant leg and arm muscles. It is replaced by isoform SERCA1a in more matured neonatal muscles and is completely absent in human foetal and neonatal diaphragm. Only isoform SERCA1a and not SERCA1is detected in muscles of 7-12 years old boys with Duchenne. In adult patients with myotonic dystrophy type 2 the SERCA1b isoform dominates over SERCA1a
brenda
-
-
brenda
-
brenda
-
masticatory, fast, masseter, and pterygoid muscles, determination of enzyme activity distribution in different muscle types, overview
brenda
-
back and leg muscles
brenda
axial abdominal muscle, expression and activity during molting cycle, overview
brenda
-
-
brenda
-
only isoform PMCA1
brenda
-
-
brenda
-
highest protein content and activity in muscle
brenda
-
-
brenda
-
SPCA1 localizes in the initial part of primary dendritic trunk in main cortical, hippocampal and cerebellar neurons from the earliest postnatal stages
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
fast muscle
brenda
-
brenda
-
-
brenda
the PMCA3 and PMCA4 pumps are expressed in skeletal muscles
brenda
the PMCA3 pump is expressed in skeletal muscles
brenda
-
-
brenda
the PMCA3 and PMCA4 pumps are expressed in skeletal muscles
brenda
predominant expression of splice variant PMCA4e
brenda
-
-
210474 , 210475 , 210478 , 210484 , 210490 , 210493 , 210496 , 670493 , 695859 , 695863 , 698270 , 698857 , 698885 , 733861 , 750181 brenda
-
brenda
-
-
brenda
-
brenda
-
brenda
hind-leg white muscle
brenda
-
fast twitch skeletal muscle
brenda
from hind leg
brenda
-
psoas muscle
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
PMCA4 is the most abundant isoform in smooth muscles
brenda
-
-
brenda
PMCA4 is the most abundant isoform in smooth muscles
brenda
-
-
brenda
-
-
-
brenda
-
brenda
the PMCA4 pump is expressed in spermatozoa
brenda
-
-
brenda
-
-
brenda
-
brenda
the PMCA4 pump is expressed in stomach
brenda
predominant expression of splice variant PMCA4e
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
-
brenda
-
isozyme SPCA2
brenda
PMCA4 is expressed at particularly high levels in the testis (more than 90% of PMCA protein expressed there is isoform 4)
brenda
-
brenda
PMCA4 is expressed at particularly high levels in the testis (more than 90% of PMCA protein expressed there is isoform 4)
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
predominant expression of splice variant PMCA4e
brenda
-
-
brenda
-
-
brenda
additional information
-
enzyme expression pattern, overview
brenda
additional information
-
isozyme SPCA1 is ubiquitously expressed, while SPCA2 is limited to some tissues
brenda
additional information
-
isozyme SPCA1 shows a less limited tissue distribution than isozyme SPCA2
brenda
additional information
SPCA2 expression pattern, overview
brenda
additional information
-
SPCA2 expression pattern, overview
brenda
additional information
liver show negligible PMCA4 expression
brenda
additional information
-
PMCA1 and PMCA4 isoforms are distributed ubiquitously, PMCA2 and 3 are found mainly in excitable cell types
brenda