7.2.2.10: P-type Ca2+ transporter This is an abbreviated version! For detailed information about P-type Ca2+ transporter, go to the full flat file .
Reaction
ATP +
H2O +
Ca2+[side 1] =
ADP +
phosphate +
Ca2+[side 2]
Synonyms ACA, ACA2, ACA8, adenosinetriphosphatase, AfPMR1, AtECA1, ATP-consuming plasma membrane calcium pump, ATP-dependent Ca(2+) pump PMR1, ATP-dependent Ca2+ pump PMR1, ATP-dependent calcium ATPase, Atp2b, ATP6, ATPase 2C1, auto-inhibited Ca2+-ATPase, autoinhibited Ca2+-ATPase, Ca(2+)-transporting ATPase, Ca-ATPase, Ca2+ -ATPase, Ca2+ ATPase, Ca2+ ATPase of sarcoplasmic reticulum, Ca2+ pump, Ca2+ pumping ATPase, Ca2+ transport ATPase, Ca2+ transport ATPase of sarco-endoplasmic reticulum, Ca2+,Mn2+-ATPase, Ca2+-ATPase, Ca2+-ATPase 6, Ca2+-ATPase 8, Ca2+-ATPase pump, Ca2+-ATPase, isoform 10, Ca2+-ATPase, isoform 11, Ca2+-ATPase, isoform 12, Ca2+-ATPase, isoform 13, Ca2+-dependent ATPase, Ca2+-Mg2+-ATPase, Ca2+-pumping ATPase, Ca2+-transporting ATPase, Ca2+/Mn2+ ATPase pump, Ca2+/Mn2+ P-type ATPase, Ca2+/Mn2+-ATPase 1, Ca2+/Mn2+-ATPase 2, calcium and manganese transporting ATPase, calcium pump, calcium-dependent ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, calcium-transporting ATPase type 2C member 1, CePMR-1, ChkSERCA3, Cod1 protein, Cod1p, EC 3.6.1.3, EC 3.6.1.38, EC 3.6.3.8, eCA, ECA1, ECA2, ECA3, ECA4, endomembrane Ca2+-ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase, endosomal Ca2+/Mn2+ pump, ER-type Ca2+-ATPase, Golgi Ca2+-ATPase, HUSSY-28, LCA, LCA1, Mn2+-transporting P-type ATPase, More, P-type ATPase, P-type Ca2+-ATPase, P-type Ca2+/Mn2+ ATPase, P-type Ca2+/Mn2+-ATPase, P-type calcium ATPase, P2A Ca2+ pump, P2A Ca2+-ATPase, P2B Ca2+ pump, P2B Ca2+-ATPase, PCA1, PCMA4b, PfATP6, phosphatase, adenosine tri, plasma membrane ATPase related 1, plasma membrane Ca-ATPase, plasma membrane Ca2+, plasma membrane Ca2+ ATPase, plasma membrane Ca2+ pump 4xb, plasma membrane Ca2+-ATPase, plasma membrane Ca2+-ATPase 1, plasma membrane Ca2+-ATPase 2, plasma membrane Ca2+-ATPase 4, plasma membrane Ca2+-ATPase 4xb, plasma membrane Ca2+-ATPase isoform 4, plasma membrane Ca2+-ATPase isoform ACA8, plasma membrane Ca2+-ATPase-4, plasma membrane Ca2+-pump, plasma membrane calcium ATPase, plasma membrane calcium ATPase 2 calcium pump, plasma membrane calcium pump, plasma-membrane Ca2+-ATPase, plasmalemmal Ca2+ pump isoform 2, plasmalemmal Ca2+-ATPase, PM Ca2+-ATPase, PMCA, PMCA pump, PMCA1, PMCA2, PMCA3, PMCA4, PMCA4a, PMCA4b, PMR1, PMR1-like calcium ATPase, Pmr1p, sarco(endo)plasmic reticulum ATPase, sarco(endo)plasmic reticulum Ca2+ ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase, sarco(endo)plasmic reticulum Ca2+-ATPase 2b, sarco(endo)plasmic reticulum calcium ATPase, sarco-endoplasmic reticulum Ca2+ ATPase, sarco-endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum Ca2+ ATPase, sarco/endoplasmic reticulum Ca2+ ATPase 3, sarco/endoplasmic reticulum Ca2+-ATPase, sarco/endoplasmic reticulum calcium ATPase, sarcoendoplasmic reticulum Ca2+ ATPase6, sarcoendoplasmic reticulum Ca2+-ATPase, sarcoendoplasmic reticulum Ca2+-ATPase isoform 1a, sarcoendoplasmic reticulum calcium ATPase, sarcolemmal Ca2+-ATPase, sarcoplasmic reticulum (Ca2+)-ATPase, sarcoplasmic reticulum ATPase, sarcoplasmic reticulum Ca(2+)-ATPase, sarcoplasmic reticulum Ca-ATPase, sarcoplasmic reticulum Ca2+ ATPase, sarcoplasmic reticulum Ca2+ ATPase 1, sarcoplasmic reticulum Ca2+ ATPase 2, sarcoplasmic reticulum Ca2+ ATPase pump, sarcoplasmic reticulum Ca2+-ATPase, sarcoplasmic reticulum Ca2+-ATPase 1, sarcoplasmic reticulum Ca2+-pump ATPase, sarcoplasmic reticulum calcium ATPase, sarcoplasmic reticulum calcium pump, sarcoplasmic reticulum calcium-dependent adenosine triphosphatase, sarcoplasmic-endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, sarcoplasmic/endoplasmic reticulum calcium ATPase, secretory pathway Ca-ATPase, Secretory pathway Ca2+ transporting ATPase, secretory pathway Ca2+-ATPase, secretory pathway Ca2+-ATPase 1, secretory pathway Ca2+/Mn2+-ATPase, SERCA, SERCA 1, SERCA 2, SERCA 3, SERCA pump, SERCA-1, SERCA-like calcium ATPase, SERCA1, SERCA1a, SERCA1b, SERCA2, SERCA2a, SERCA2b, SERCA3, SERCA3a, SERCA3b, SERCA3c, SERCA3d, SERCA3f, SMA1, SPCA, SPCA1, SPCA2, Spf1, SR Ca-ATPase, SR Ca2+-ATPase, Vacuolar Ca2+-ATPase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 7.2.2.10 - P-type Ca2+ transporter
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ATP + H2O
ADP + phosphate
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?
ATP + H2O + 2 Ca2+[cytoplasm side]
ADP + phosphate + 2 Ca2+[lumen side]
ATP + H2O + 2 Ca2+[side 1]
ADP + phosphate + 2 Ca2+[side 2]
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
ATP + H2O + Ca2+/in
ADP + phosphate + Ca2+/out
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plasma-membrane Ca2+-ATPase is a calcium pump that exports Ca2+ from the cytosol to the extracellular environment of eukaryotic cells and thus maintain overall Ca2+ homoeostasis and provide local control of intracellular Ca2+ signalling
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?
ATP + H2O + Ca2+/out
ADP + phosphate + Ca2+/in
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
ATP + H2O + Ca2+[side 1] + H+[side 2]
ADP + phosphate + Ca2+[side 2] + H+[side 1]
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?
ATP + H2O + Mn2+/cis
ADP + phosphate + Mn2+/trans
additional information
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ATP + H2O + 2 Ca2+[cytoplasm side]
ADP + phosphate + 2 Ca2+[lumen side]
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?
ATP + H2O + 2 Ca2+[cytoplasm side]
ADP + phosphate + 2 Ca2+[lumen side]
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?
ATP + H2O + 2 Ca2+[side 1]
ADP + phosphate + 2 Ca2+[side 2]
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ATP + H2O + 2 Ca2+[side 1]
ADP + phosphate + 2 Ca2+[side 2]
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
Homarus sp.
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ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
ATPase activity and Ca2+ transport activity
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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the enzyme is a plasma membrane calcium pump performing Ca2+-dependent ATPase and ATP-dependent Ca2+ transport reactions
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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SERCA1 is responsible for ATPase activity and intermediate reactions, as well as ATP-dependent Ca2+ transport
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ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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the enzyme is the Ca2+ pump in sarcoplasmic reticulum membranes
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ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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the enzyme is the Ca2+ pump in sarcoplasmic reticulum membranes, the ATP hydrolysis energy is used for uphill transport and accumulation of Ca2+
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r
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
the enzyme performs ATP-dependent Ca2+ transport and Ca2+-dependent ATPase activity
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?
ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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sarcoplasmic reticulum Ca-ATPase transports calcium ions from the myoplasm to the reticulum lumen at the expense of ATP hydrolysis
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ATP + H2O + Ca2+/cis
ADP + phosphate + Ca2+/trans
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?
ATP + H2O + Ca2+/out
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responsible for Ca2+ uptake into the alveolar sac
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?
ATP + H2O + Ca2+/out
?
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responsible for Ca2+ uptake into the alveolar sac
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ATP + H2O + Ca2+/out
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high affinity (Ca2+-Mg2+)-ATPase is responsible for Ca2+ transport
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ATP + H2O + Ca2+/out
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filling of the Ca2+ pool in the endoplasmic reticulum
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?
ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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?
ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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?
ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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733067 , 733277 , 733466 , 734224 , 734517 , 735113 , 748570 , 749980 , 750486 , 750998 , 751700 , 752192 -
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
Plasmodium falciparum isolate K1
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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best substrate
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ATP + H2O + Ca2+[side 1]
ADP + phosphate + Ca2+[side 2]
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ATP + H2O + Mn2+/cis
ADP + phosphate + Mn2+/trans
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Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities
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?
ATP + H2O + Mn2+/cis
ADP + phosphate + Mn2+/trans
Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities
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?
ATP + H2O + Mn2+/cis
ADP + phosphate + Mn2+/trans
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Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities
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?
ATP + H2O + Mn2+/cis
ADP + phosphate + Mn2+/trans
Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities
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additional information
?
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isoform ECA3 function cannot be replaced by an endoplasmic reticulum-associated isoform ECA1, ECA3 is also important for the detoxification of excess Mn2+, isoform ECA3 is a distinct Ca2+/Mn2+ pump critical for Ca2+-enhanced root growth
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additional information
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isoform ECA3 function cannot be replaced by an endoplasmic reticulum-associated isoform ECA1, ECA3 is also important for the detoxification of excess Mn2+, isoform ECA3 is a distinct Ca2+/Mn2+ pump critical for Ca2+-enhanced root growth
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additional information
?
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isoform ECA3 function cannot be replaced by an endoplasmic reticulum-associated isoform ECA1, ECA3 is also important for the detoxification of excess Mn2+, isoform ECA3 is a distinct Ca2+/Mn2+ pump critical for Ca2+-enhanced root growth
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additional information
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isoform ECA3 function cannot be replaced by an endoplasmic reticulum-associated isoform ECA1, ECA3 is also important for the detoxification of excess Mn2+, isoform ECA3 is a distinct Ca2+/Mn2+ pump critical for Ca2+-enhanced root growth
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additional information
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the enzyme is involved in calcium and maganese homeostasis
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additional information
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the P-type calcium ATPase is important for calcium/manganese homeostasis and oxidative stress response
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additional information
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the enzyme is a P-type Ca2+/Mn2+-ATPase involved in the secretory pathway
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additional information
?
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the enzyme is a P-type Ca2+/Mn2+-ATPase involved in the secretory pathway
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additional information
?
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the enzyme performs ATP-dependent Ca2+ transport and Ca2+-dependent ATPase activity, functional regulation by phospholamban
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?
additional information
?
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Homarus sp.
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the enzyme is involved in the transepithelial Ca2+ flow in hepatopancreas of lobster acting as an ATP-driven Ca2+ pump in conjunction with a Na+/Ca2+ antiporter in the basolateral cell region, Ca2+ transport mechanism by endoplasmic reticular vesicles, overview
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additional information
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the Ca2+,Mn2+-ATPase SPCA2 is involved in the secretory pathway
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additional information
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the enzyme is important in the secretory pathway
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additional information
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the enzyme is important in the secretory pathway
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additional information
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PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk
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additional information
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PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk
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additional information
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PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk
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additional information
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PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk
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additional information
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the activity of the plasma membrane Ca2+-pump decreases steeply throughout the 120 days lifespan of normal human red blood cells, the Ca2+ pump is a major regulator of Ca2+ homeostasis in all cells
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additional information
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PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk
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additional information
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interaction of Ca2+-ATPase with phospholamban is involved in regulation of heart contractility, overview
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additional information
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the enzyme performs ATP-dependent Ca2+ transport and Ca2+-dependent ATPase activity
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additional information
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SERCA 2 type Ca2+-ATPases dominate in red muscle and blood platelets where this heat flux is not so central
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additional information
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SERCA 2 type Ca2+-ATPases dominate in red muscle and blood platelets where this heat flux is not so central
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additional information
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SERCA 2 type Ca2+-ATPases dominate in red muscle and blood platelets where this heat flux is not so central
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additional information
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the SERCA 1 Ca2+-ATPase in white muscle is able to work as ion pumps, but clearly also as heat pumps because of their large ATPase activity. This may explain why SERCA 1 type Ca2+-ATPases dominate in tissues where thermal regulation is important.
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additional information
?
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the SERCA 1 Ca2+-ATPase in white muscle is able to work as ion pumps, but clearly also as heat pumps because of their large ATPase activity. This may explain why SERCA 1 type Ca2+-ATPases dominate in tissues where thermal regulation is important.
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additional information
?
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the SERCA 1 Ca2+-ATPase in white muscle is able to work as ion pumps, but clearly also as heat pumps because of their large ATPase activity. This may explain why SERCA 1 type Ca2+-ATPases dominate in tissues where thermal regulation is important.
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additional information
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the enzyme performs ATP-dependent Ca2+ transport and Ca2+-dependent ATPase activity
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additional information
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the enzyme performs ATP-dependent Ca2+ transport and Ca2+-dependent ATPase activity
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additional information
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the enzyme plays a significant role in cellular Ca2+ homeostasis
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additional information
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the enzyme is responsible for the Ca2+ sequestering
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