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2.7.4.1: ATP-polyphosphate phosphotransferase

This is an abbreviated version!
For detailed information about ATP-polyphosphate phosphotransferase, go to the full flat file.

Word Map on EC 2.7.4.1

Reaction

ATP
+
(Phosphate)n
=
ADP
 +
(phosphate)n+1

Synonyms

AAur2811, AjPPK, ATP:polyphosphate phosphotransferase, AUJ86_09545, CHU0107, CHU_0107, class I PPK2, class II polyphosphate kinase, class III PPK2, Deipr_1912, DR0132, DR_0132, ES2, family-2 polyphosphate kinase, FTT_1564, glycogen-bound polyphosphate kinase, GmSuSy, I601_4057, K649_10090, kinase, polyphosphate (phosphorylating), More, MrH2468, Mrub_2488, MXAN_0056, NCg12620, OsIPK2, PA0141, PA3455 protein, paPpx, plyphosphate kinase 1, poly P kinase 1, poly(P) kinase 1, poly(P) kinase 2, poly-P kinase, poly-P kinase 1, polyP kinase, polyphosphate kinase, polyphosphate kinase 1, polyphosphate kinase 2, polyphosphate kinase 3, polyphosphate kinase-1, polyphosphate kinase-2, polyphosphate-dependent nucleoside diphosphate kinase, polyphosphate: ADP phosphotransferase, polyphosphate:ADP phosphotransferase, polyphosphate:nucleotide phosphotransferase, polyphosphoric acid kinase, PPK, PPK-2, PPK1, PPK2, PPK2-1, PPK2-2, PPK2-3, PPK2a, PPK2B, PPK2c, PPK2d, PPK2e, PPK3, Rv3232c, SMc02148, SMc02148 protein, SPO0224, SPO1256, SPO1727

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.1 ATP-polyphosphate phosphotransferase

Inhibitors

Inhibitors on EC 2.7.4.1 - ATP-polyphosphate phosphotransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2-anilinoethane-1,1-diyl)bis(phosphonic acid)
(2E)-2-[(4-nitrophenyl)methylidene]-4,4-diphosphonobutanoic acid
(NH4)2SO4
2-[2-amino-3-[(2-amino-3-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-oxopropyl)disulfanyl]propanamido]-3-(4-hydroxyphenyl)propanoic acid
treating the wild-type Escherichia coli with the inhibitor, at 0.050 mM, results in a metabolic fingerprint that is an almost identicalntical metabolic behavior to the ppk1 knockout mutant
6-(4-aminobenzamido)-5-[(E)-[1-(2-chloro-5-sulfophenyl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]diazenyl]naphthalene-2-sulfonic acid
treating the wild-type Escherichia coli with the inhibitor, at 0.050 mM, results in a metabolic fingerprint that is completely identical to that of ppk1 knockout mutant
ammonium hydrochloride
-
50% inhibition at 200 mM
Ca2+
-
1 mM, 10% inhibition
Cu2+
-
0.1 mM, 92% inhibition, 1 mM, complete inhibition
diphosphate
ellagic acid
Q9S646
ellagic acid derivatives from Terminalia chebula increase the susceptibility of Pseudomonas aeruginosa to stress by inhibiting polyphosphate kinase, oveview. Ellagic acid derivatives completely inhibit PPK1 activity at 0.5 mg/ml. Ellagic acid derivatives-treated Pseudomonas aeruginosa cells show marked reduction in polyphosphate granules in cytosol. Ellagic acid derivatives from Terminalia chebula inhibit PPK1 expression and its activity and increase the sensitivity of Pseudomonas aeruginosa to desiccation and oxidative stress while reducing tolerance to piperacillin
G-quadruplex thrombin binding aptamer
binds to PPK2 with a KD of 870 nM, noncompetitive
-
Guanidine HCl
-
5 mM, 50% inhibition of polyphosphate synthesis
guanosine 5'-tetraphosphate
histone
-
reverse reaction, strong, activates forward reaction in the presence of phosphate
hydrolyzed glycogen
-
complete inhibition
-
MnATP2-
-
at high concentrations, above 0.6 mM, activating below
NH4Cl
-
200 mM, approx. 50% inhibition of glycogen-bound polyphosphate kinase
NSC-30205
0.1 mM, inhibits more than 80%, cytotoxic to THP-1 macrophages with TC50 value 0.01 mM
-
NSC-345647
0.1 mM, inhibits more than 80%, cytotoxic to THP-1 macrophages with TC50 value 0.005 mM
-
NSC-35676
0.1 mM, inhibits more than 80%, non-cytotoxic to THP-1 cells even at 0.05 mM concentration
-
NSC-9037
0.1 mM, inhibits more than 80%, non-cytotoxic to THP-1 cells even at 0.05 mM concentration
-
phalloidin
a heptapeptide toxin from the mushroom Amanita phalloides, which binds tightly and specifically to polymerized actin, inhibits DdPPK2 and DdPPK1, the latter by 80% at 10 nM, the molar ratio of phalloidin to DdPPK1 of 10:15 results in complete inhibition of DdPPK1 activity
phosphate
Polyphosphate
polyphosphate(4)
-
Sodium fluoride
-
slight inhibition
threonyltyrosyl-N-[(1R)-1-[(3-aminopropyl)amino]-2-(carboxyoxy)-2-oxoethyl]serinamide
poor chemical inhibitor of PPK1, it shows a drop of approximately 20% in the WT biofilm formation ability
vanadate
-
-
Zn2+
-
0.1 mM, 67% inhibition, 1 mM, complete inhibition
[(2,3-dichloroanilino)methylene]bis(phosphonic acid)
-
[(3,5-dichloroanilino)methylene]bis(phosphonic acid)
-
[(3-aminoanilino)methylene]bis(phosphonic acid)
[(3-carbamimidamidoanilino)methylene]bis(phosphonic acid)
[(4-benzylanilino)methylene]bis(phosphonic acid)
-
[2-(2,3-dichlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
-
[2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
[2-(3-chloroanilino)ethane-1,1-diyl]bis(phosphonic acid)
[2-(3-nitroanilino)ethane-1,1-diyl]bis(phosphonic acid)
-
[2-[(1-amino-2-methylbutyl)(hydroxy)phosphoryl]ethyl]phosphonic acid
additional information
-