2.7.4.1: ATP-polyphosphate phosphotransferase
This is an abbreviated version!
For detailed information about ATP-polyphosphate phosphotransferase, go to the full flat file.
Word Map on EC 2.7.4.1
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2.7.4.1
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phosphorus
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exopolyphosphatase
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molecular biology
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wastewater
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sludge
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polyhydroxyalkanoates
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accumulibacter
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candidatus
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synthesis
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polyphosphatase
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medicine
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phosphoanhydride
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phosphatis
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biotechnology
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drug development
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analysis
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industry
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environmental protection
- 2.7.4.1
- phosphorus
- exopolyphosphatase
- molecular biology
-
wastewater
- sludge
- polyhydroxyalkanoates
- accumulibacter
-
candidatus
- synthesis
- polyphosphatase
- medicine
-
phosphoanhydride
- phosphatis
- biotechnology
- drug development
- analysis
- industry
- environmental protection
Reaction
Synonyms
AAur2811, AjPPK, ATP:polyphosphate phosphotransferase, AUJ86_09545, CHU0107, CHU_0107, class I PPK2, class II polyphosphate kinase, class III PPK2, Deipr_1912, DR0132, DR_0132, ES2, family-2 polyphosphate kinase, FTT_1564, glycogen-bound polyphosphate kinase, GmSuSy, I601_4057, K649_10090, kinase, polyphosphate (phosphorylating), More, MrH2468, Mrub_2488, MXAN_0056, NCg12620, OsIPK2, PA0141, PA3455 protein, paPpx, plyphosphate kinase 1, poly P kinase 1, poly(P) kinase 1, poly(P) kinase 2, poly-P kinase, poly-P kinase 1, polyP kinase, polyphosphate kinase, polyphosphate kinase 1, polyphosphate kinase 2, polyphosphate kinase 3, polyphosphate kinase-1, polyphosphate kinase-2, polyphosphate-dependent nucleoside diphosphate kinase, polyphosphate: ADP phosphotransferase, polyphosphate:ADP phosphotransferase, polyphosphate:nucleotide phosphotransferase, polyphosphoric acid kinase, PPK, PPK-2, PPK1, PPK2, PPK2-1, PPK2-2, PPK2-3, PPK2a, PPK2B, PPK2c, PPK2d, PPK2e, PPK3, Rv3232c, SMc02148, SMc02148 protein, SPO0224, SPO1256, SPO1727
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2.7.4.1 ATP-polyphosphate phosphotransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.4.1 - ATP-polyphosphate phosphotransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP + (phosphate)n
ATP + (phosphate)n-1
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-
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r
ADP + (phosphate)n
ATP + (phosphate)n-1
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-
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?
ADP + (phosphate)n+1
ATP + (phosphate)n
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polyphosphate kinases (PPKs) catalyzes the polyP formation or ATP formation, to store energy or to regenerate ATP, respectively
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-
r
ADP + (phosphate)n+1
ATP + (phosphate)n
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polyphosphate kinase directly or indirectly regulates DNA polymerase activity or fidelity
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-
?
ADP + (phosphate)n+1
ATP + (phosphate)n
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-
-
?
ADP + (phosphate)n+1
ATP + (phosphate)n
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-
-
?
ADP + (phosphate)n+1
ATP + (phosphate)n
when Ppk1 from Myxococcus xanthus is incubated with 0.2 mM polyP60-70 and 1 mM ATP or ADP, the rate of ATP synthesis is approximately 1.5-fold higher than that of polyP synthesis. If in the same reaction the proportion of ADP in the ATP/ADP mixture exceeds one-third, the equilibrium shifts to ATP synthesis, suggesting that the enzyme preferentially catalyzed ATP formation
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-
r
ADP + (phosphate)n+1
ATP + (phosphate)n
when Ppk1 from Myxococcus xanthus is incubated with 0.2 mM polyP60-70 and 1 mM ATP or ADP, the rate of ATP synthesis is approximately 1.5-fold higher than that of polyP synthesis. If in the same reaction the proportion of ADP in the ATP/ADP mixture exceeds one-third, the equilibrium shifts to ATP synthesis, suggesting that the enzyme preferentially catalyzed ATP formation
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-
r
ADP + (phosphate)n+1
ATP + (phosphate)n
enzyme is involved in polyphosphate synthesis. The polyphosphate kinase gene is transcribed from a sigma(E) dependent promoter, which could be responsive to environmental stresses
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-
?
ADP + (phosphate)n+1
ATP + (phosphate)n
enzyme is involved in polyphosphate synthesis. The polyphosphate kinase gene is transcribed from a sigma(E) dependent promoter, which could be responsive to environmental stresses
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-
?
ADP + (phosphate)n+1
ATP + (phosphate)n
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the enzyme protects Salmonella enterica from weak organic acid stress. Polyphosphate may acts as a chemical chaperone that helps refold homoserine transsuccinylase and/or may stimulate proteolysis of toxic denatured protein. The instability of homoserine transsuccinylase may provide a metabolic fuse that blocks growth under conditions that denature proteins. The sensitivity of this fuse is modulated by polyphosphate
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-
?
ADP + (phosphate)n+1
ATP + (phosphate)n
polyphosphate kinases (PPKs) catalyzes the polyP formation or ATP formation, to store energy or to regenerate ATP, respectively
-
-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
polyphosphate utilization and accumulation contribute significantly to Campylobacter jejuni pathogenesis and affect its ability to adapt to specific stresses and stringencies
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-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
polyphosphate utilization and accumulation contribute significantly to Campylobacter jejuni pathogenesis and affect its ability to adapt to specific stresses and stringencies
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-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
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PPK2B forms polyphopshate with an average chain length of about 125
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-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
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polyphosphate kinases (PPKs) catalyzes the polyP formation or ATP formation, to store energy or to regenerate ATP, respectively
-
-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
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PPK2B forms polyphopshate with an average chain length of about 125
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-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
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-
-
?
ATP + (phosphate)n
ADP + (phosphate)n+1
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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-
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?
ATP + (phosphate)n
ADP + (phosphate)n+1
PPK1 is the principal enzyme responsible for reversible synthesis of polyphosphate from the terminal phosphate of ATP
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-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
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polyphosphate kinase may be involved in nucleotide metabolism
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?
ATP + (phosphate)n
ADP + (phosphate)n+1
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involved in phosphate metabolism of bacteria
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r
ATP + (phosphate)n
ADP + (phosphate)n+1
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essential role of the enzyme during the initial steps of colonisation of the mouse gastric mucosa. The enzyme may act on the virulence of Helicobacter pylori partly through an energy dependent mechanism
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-
?
ATP + (phosphate)n
ADP + (phosphate)n+1
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
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-
-
-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
when Ppk1 from Myxococcus xanthus is incubated with 0.2 mM polyP60-70 and 1 mM ATP or ADP, the rate of ATP synthesis is approximately 1.5-fold higher than that of polyP synthesis. If in the same reaction the proportion of ADP in the ATP/ADP mixture exceeds one-third, the equilibrium shifts to ATP synthesis, suggesting that the enzyme preferentially catalyzes ATP formation
-
-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
when Ppk1 from Myxococcus xanthus is incubated with 0.2 mM polyP60-70 and 1 mM ATP or ADP, the rate of ATP synthesis is approximately 1.5-fold higher than that of polyP synthesis. If in the same reaction the proportion of ADP in the ATP/ADP mixture exceeds one-third, the equilibrium shifts to ATP synthesis, suggesting that the enzyme preferentially catalyzes ATP formation
-
-
r
ATP + (phosphate)n
ADP + (phosphate)n+1
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PPK1 is essential for a successful ocular infection by the organism
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-
?
ATP + (phosphate)n
ADP + (phosphate)n+1
polyphosphate kinases (PPKs) catalyzes the polyP formation or ATP formation, to store energy or to regenerate ATP, respectively
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-
r
CDP + (phosphate)n
CTP + (phosphate)n-1
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-
-
?
GDP + (phosphate)n
GTP + (phosphate)n-1
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-
-
?
GDP + (phosphate)n+1
GTP + (phosphate)n
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efficiency of NDP substrates in descending order: ADP, dADP, dGDP, GDP, TDP, UDP, CDP, dCDP
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ir
GDP + (phosphate)n+1
GTP + (phosphate)n
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10times higher activity than Escherichia coli polyphosphate kinase
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ir
UDP + (phosphate)n
UTP + (phosphate)n-1
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-
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?
additional information
?
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accumulation of high levels of cytosolic phosphorus in the form of polyphosphate involving classII polyphosphate kinase isozymes, granular poly P, i.e. volutin, can make up to 37% of the internal cell volume, overview
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?
additional information
?
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accumulation of high levels of cytosolic phosphorus in the form of polyphosphate involving classII polyphosphate kinase isozymes, granular poly P, i.e. volutin, can make up to 37% of the internal cell volume, overview
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?
additional information
?
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the organism also has an actin-related poly P synthesizing complex, DdPPK2, that is KCl dependent
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?
additional information
?
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the organism also has an actin-related poly P synthesizing complex, DdPPK2, that is KCl dependent
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?
additional information
?
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polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria, PPK1 is required for the stringent response, under conditions of stress polyP acts as a preferred donor for MprB-mediated phosphorylation of MprA facilitating transcription of the sigE gene thereby leading finally to the enhancement of the transcription of rel in Mycobacterium tuberculosis, overview
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-
?
additional information
?
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polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria, PPK1 is required for the stringent response, under conditions of stress polyP acts as a preferred donor for MprB-mediated phosphorylation of MprA facilitating transcription of the sigE gene thereby leading finally to the enhancement of the transcription of rel in Mycobacterium tuberculosis, overview
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-
?
additional information
?
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-
PPK2 interacts with and modulates nucleotide-synthesizing activity of nucleoside diphosphate kinase
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-
?
additional information
?
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-
PPK2 interacts with and modulates nucleotide-synthesizing activity of nucleoside diphosphate kinase
-
-
?
additional information
?
-
polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria, PPK1 is required for the stringent response, under conditions of stress polyP acts as a preferred donor for MprB-mediated phosphorylation of MprA facilitating transcription of the sigE gene thereby leading finally to the enhancement of the transcription of rel in Mycobacterium tuberculosis, overview
-
-
?
additional information
?
-
-
polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria, mprAB-sigE-rel signalling cascade, overview. PPK1 is required for the stringent response, under conditions of stress polyP acts as a preferred donor for MprB-mediated phosphorylation of MprA facilitating transcription of the sigE gene thereby leading finally to the enhancement of the transcription of rel in Mycobacterium smegmatis, overview
-
-
?
additional information
?
-
-
PPK2 interacts with and modulates nucleotide-synthesizing activity of nucleoside diphosphate kinase
-
-
?
additional information
?
-
-
polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria, mprAB-sigE-rel signalling cascade, overview. PPK1 is required for the stringent response, under conditions of stress polyP acts as a preferred donor for MprB-mediated phosphorylation of MprA facilitating transcription of the sigE gene thereby leading finally to the enhancement of the transcription of rel in Mycobacterium smegmatis, overview
-
-
?
additional information
?
-
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
PPK2 interacts with and modulates nucleotide-synthesizing activity of nucleoside diphosphate kinase
-
-
?
additional information
?
-
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria, mprAB-sigE-rel signalling cascade, overview. PPK1 is required for the stringent response, under conditions of stress polyP acts as a preferred donor for MprB-mediated phosphorylation of MprA facilitating transcription of the sigE gene thereby leading finally to the enhancement of the transcription of rel in Mycobacterium smegmatis, overview
-
-
?
additional information
?
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gene ppk regulates the transcription accumulation of the stationary-phase sigma factor RpoS encoded by the rpoS gene, overview
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?
additional information
?
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the enzyme PPK from Streptomyces lividans also exhibits weak phospholipase D activity, EC 3.1.4.4, hydrolysing phosphatidylcholine, quantification of [3H]phosphatidic acid released from [3H]PC-labeled ELT3 cell membranes from phospholipase D-deficient cells, overview
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?
