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5'-deoxy-5'-(hydroxyethylthio)adenosine + phosphate
adenine + 5-hydroxyethylthio-D-ribose 1-phosphate
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5'-deoxy-5'-methyl-thio-D-ribose-1-phosphate
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-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
adenosine + phosphate
adenine + D-ribose 1-phosphate
guanosine + phosphate
guanine + D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + D-ribose 1-phosphate
-
-
-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
additional information
?
-
5'-deoxy-5'-(hydroxyethylthio)adenosine + phosphate
adenine + 5-hydroxyethylthio-D-ribose 1-phosphate
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trypanocidal substrate analogue
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-
?
5'-deoxy-5'-(hydroxyethylthio)adenosine + phosphate
adenine + 5-hydroxyethylthio-D-ribose 1-phosphate
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preincubation of cells with the substrate lead to 22-37% inhibition of spermidine synthesis from ornithine and 2-7fold increased cytosolic levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine, and up to 8fold increased cytosolic level of 5'-methyladenosine
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-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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salvage reaction
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-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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involved in cardiac purine breakdown during ischemia
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-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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substrate is a by-product of polyamine biosynthesis, which is essential for cell growth and proliferation
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-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
Caldariella acidophila
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an antiproliferative effect on stimulated human lymphocytes and virally transformed mouse fibroblasts
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-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
Caldariella acidophila
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involved in salvage of adenine and methionine from 5'-methylthioadenosine
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-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
Caldariella acidophila
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physiological significance of 5'-methylthioadenosine cleavage is probably related to removal of the thioether which in turn exerts a significant inhibition on methyl transfer reactions
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-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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-
-
-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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important for the salvage of adenine and methionine
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-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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involved in salvage of adenine and methionine from 5'-methylthioadenosine
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-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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involved in salvage of adenine and methionine from 5'-methylthioadenosine
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-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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-
-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
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the enzyme regulates ornithine decarboxylase by production of downstream metabolites. Tumor suppressor activity of MTAP may be due to its effect on ornithine decarboxylase activity
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?
adenosine + phosphate
adenine + D-ribose 1-phosphate
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-
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?
adenosine + phosphate
adenine + D-ribose 1-phosphate
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?
adenosine + phosphate
adenine + D-ribose 1-phosphate
the enzyme can use adenosine with the same efficiency as 5'-deoxy-5'-methylthioadenosine
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?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
-
ir
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
-
-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
-
-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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phosphorolysis
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-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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recycling of 5'-methylthioadenosine, the byproduct from spermine and spermidine synthesis, to S-adenosylmethionine, the precursor for polyamine synthesis, pathway overview
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-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
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?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
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-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
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-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
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-
?
S-methyl-5'-thioadenosine + phosphate
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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-
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?
additional information
?
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enzyme plays a role in purine and polyamine metabolism and in the regulation of transmethylation reactions
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?
additional information
?
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enzyme plays a role in purine and polyamine metabolism and in the regulation of transmethylation reactions
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?
additional information
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inverse correlation between enzyme expression and progression of melanocytic tumors, important role of enzyme inactivation in the development of melanomas
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?
additional information
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enzyme is involved in the methionine dependent tumor cell growth
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?
additional information
?
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many malignant cells lack MTAP activity because of chromosomal loss or epigeneticregulation
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?
additional information
?
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principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms, intracellular Mtap protein levels determine response to purine biosynthesis inhibitor L-alanosine, overview
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?
additional information
?
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involved in the catabolism of 5'-methylthioadenosine, adenosine, guanosine and inosine
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?
additional information
?
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involved in the catabolism of 5'-methylthioadenosine, adenosine, guanosine and inosine
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?
additional information
?
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metabolic pathway, overview
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?