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Literature summary for 2.4.2.28 extracted from

  • Yu, J.; Batova, A.; Shao, L.e.; Carrera, C.J.; Yu, A.L.
    Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies (1997), Clin. Cancer Res., 3, 433-438.
    View publication on PubMed

Application

Application Comment Organism
medicine possibility of targeting the enzyme in the design of an enzyme-selective therapy for patients with T-cell acute lymphoblastic leukemia and other enzyme-deficient malignancies Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-methylthioadenosine + phosphate Homo sapiens important for the salvage of adenine and methionine adenine + 5-methylthio-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic stem cell and progenitor cells Homo sapiens
-
MOLT-4 cell
-
Homo sapiens
-
additional information enzyme is deficient in patients with T-cell acute lymphoblastic leukemia, no activity in enzyme-deficient CEM cells Homo sapiens
-
peripheral blood
-
Homo sapiens
-
peripheral blood mononuclear cell CD34+ erythroid burst-forming unit, granulocyte/monocyte colony-forming unit, granulocyte/erythrocyte/macrophage/megakaryocyte colony-forming unit progenitors and primitive high proliferative potential colony-forming cells in the purified CD34+ cells are cultured Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-methylthioadenosine + phosphate
-
Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
?
5'-methylthioadenosine + phosphate important for the salvage of adenine and methionine Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
?