Literature summary for 2.4.2.28 extracted from

Subhi, A.L.; Diegelman, P.; Porter, C.W.; Tang, B.; Lu, Z.J.; Markham, G.D.; Kruger, W.D.
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites (2003), J. Biol. Chem., 278, 49868-49873.

Search for more literature for 2.4.2.28

Cloned(Commentary)

Cloned (Comment)	Organism
expression of MTAP in MTAP-deleted MCF-7 breast adenocarcinoma cells results in a significant reduction of ODC activity	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5'-methylthioadenosine + phosphate	Saccharomyces cerevisiae	the enzyme regulates ornithine decarboxylase by production of downstream metabolites. Tumor suppressor activity of MTAP may be due to its effect on ornithine decarboxylase activity	adenine + 5-methylthio-D-ribose 1-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-methylthioadenosine + phosphate	-	Saccharomyces cerevisiae	adenine + 5-methylthio-D-ribose 1-phosphate	-	?
5'-methylthioadenosine + phosphate	the enzyme regulates ornithine decarboxylase by production of downstream metabolites. Tumor suppressor activity of MTAP may be due to its effect on ornithine decarboxylase activity	Saccharomyces cerevisiae	adenine + 5-methylthio-D-ribose 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
MTAP	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)