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Literature summary for 2.4.2.28 extracted from

  • Behrmann, I.; Wallner, S.; Komyod, W.; Heinrich, P.C.; Schuierer, M.; Buettner, R.; Bosserhoff, A.K.
    Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma (2003), Am. J. Pathol., 163, 683-690.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.28

Cloned(Commentary)

Cloned (Comment) Organism
quantitative PCR, RNA mutational analysis, analysis of methylation status of the enzymes promotor Homo sapiens
re-expression in Mel Im cell line Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information melanoma cell line HTZ19d is a deletion mutant without enzyme expression and activity Homo sapiens
V56I natural polymorphism present in 7 of 9 melanoma cell lines, not in SK-Mel-28 and in HTZ19d Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information promotor hypermethylation strongly reduces enzyme expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inverse correlation between enzyme expression and progression of melanocytic tumors, important role of enzyme inactivation in the development of melanomas ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HMB-2 cell cell line derived from metastases of malignant melanomas Homo sapiens
-
Mel Ei cell cell line derived from primary cutaneous melanoma Homo sapiens
-
Mel Im cell cell line derived from metastases of malignant melanomas Homo sapiens
-
Mel Ju cell cell line derived from metastases of malignant melanomas Homo sapiens
-
Mel Wei cell cell line derived from primary cutaneous melanoma Homo sapiens
-
Mel-HO cell low content Homo sapiens
-
Mel-HO cell cell line derived from primary cutaneous melanoma Homo sapiens
-
MEL-JUSO cell low content Homo sapiens
-
MEL-JUSO cell cell line derived from primary cutaneous melanoma Homo sapiens
-
melanocyte primary Homo sapiens
-
melanoma cell reduced activity due to hypermethylation of the promotor Homo sapiens
-
melanoma cell line SK-Ml-28 cell line derived from metastases of malignant melanomas Homo sapiens
-
additional information strongly reduced expression in all melanoma cell lines due to promotor hypermethylation, no enzyme content and expression in melanoma cell line HTZ19d Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?
additional information inverse correlation between enzyme expression and progression of melanocytic tumors, important role of enzyme inactivation in the development of melanomas Homo sapiens ?
-
 ?