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Literature summary for 2.4.2.28 extracted from

  • Bistulfi, G.; Affronti, H.C.; Foster, B.A.; Karasik, E.; Gillard, B.; Morrison, C.; Mohler, J.; Phillips, J.G.; Smiraglia, D.J.
    The essential role of methylthioadenosine phosphorylase in prostate cancer (2016), Oncotarget, 7, 14380-14393.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
medicine the enzyme is a therapeutic target for prostate cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5'-methylthio-DaDMe-Immucillin-A
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
x * 31000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-methyl-5'-thioadenosine + phosphate Homo sapiens
-
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13126
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BPH-1 cell
-
Homo sapiens
-
brain
-
Homo sapiens
-
CWR-R1 cell
-
Homo sapiens
-
DU-145 cell
-
Homo sapiens
-
LAPC-4 cell
-
Homo sapiens
-
LNCaP cell
-
Homo sapiens
-
LNCaP-C4-2 cell
-
Homo sapiens
-
P69 cell
-
Homo sapiens
-
PC-3 cell
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-
prostate epithelium cell line
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-
RWPE-2 cell
-
Homo sapiens
-
testis
-
Homo sapiens
-
WPE-int cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-methyl-5'-thioadenosine + phosphate
-
Homo sapiens adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
?

Subunits

Subunits Comment Organism
? x * 31000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
methylthioadenosine phosphorylase
-
Homo sapiens
MTAP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown both genetically and pharmacologically, blocks androgen sensitive prostate cancer growth in vivo Homo sapiens