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2.4.2.28: S-methyl-5'-thioadenosine phosphorylase

This is an abbreviated version!
For detailed information about S-methyl-5'-thioadenosine phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.28

Reaction

S-methyl-5'-thioadenosine
+
phosphate
=
adenine
 +
S-methyl-5-thio-alpha-D-ribose 1-phosphate

Synonyms

5'-deoxy-5'-methylthioadenosine phosphorylase, 5'-deoxy-5'-methylthioadenosine phosphorylase II, 5'-deoxy-5'-methylthioadenosine:orthophosphate methylthioribosyltransferase, 5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine phosphorylase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 5-methylthioadenosine phosphorylase, 5’-methylthioadenosine phosphorylase, MeSAdo phosphorylase, MeSAdo/Ado phosphorylase, methylthioadenosine nucleosidase, methylthioadenosine nucleoside phosphorylase, methylthioadenosine phosphorylase, MTA phosphorylase, MTAN, MTAN1, MTAN2, MTAP, Mtap protein, MTAPase, MTN1, MTN2, PfMTAP, phosphorylase, methylthioadenosine, RSFP, Rv0535, SsMTAP, SsMTAP II, SsMTAPII, SSO2343

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.28 S-methyl-5'-thioadenosine phosphorylase

Specific Activity

Specific Activity on EC 2.4.2.28 - S-methyl-5'-thioadenosine phosphorylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0234
-
purified enzyme
0.0283
-
partially purified enzyme
0.048
-
substrate 2-amino-5'-deoxy-5'-(hydroxyethylthio)adenosine
0.092
-
partially purified enzyme, forward reaction, substrate 5'-methylthioadenosine
0.131
-
purified enzyme
0.17
-
substrate 5'-methyladenosine or 5'-deoxy-5'-(hydroxyethylthio)adenosine
0.25
-
substrate 2-fluoro-5'-deoxy-5'-(hydroxyethylthio)adenosine
0.26
-
substrate 5'-deoxyadenosine, forward reaction
0.365
-
substrate 5'-deoxy-5'-(hydroxyethylthio)adenosine, preincubation with substrate
0.38
with adenosine as substrate
0.46
with 5'-choroadenosine as substrate
0.67
-
purified enzyme
0.83
with 5'-choroadenosine as substrate
0.96
with S-adenosylhomocysteine as substrate
1.06
with 5'-iodoadenosine as substrate
1.36
with 5'-phenylthioadenosine as substrate
1.5
with 5'-butylthioadenosine as substrate
1.85
with 5'-isobutylthioadenosine as substrate
1.98
with 5'-isobutylthioadenosine as substrate
10.2
-
purified enzyme
10.3
-
-
11.5
with 5'-methylthioadenosine as substrate
2.44
with 5'-phenylthioadenosine as substrate
2.46
Caldariella acidophila
-
purified enzyme
2.48
Caldariella acidophila
-
purified enzyme
2.6
with 5'-ethylthioadenosine as substrate
2.72
with 5'-butylthioadenosine as substrate
3.14
with 5'-iodoadenosine as substrate
4.42
with 5'-ethylthioadenosine as substrate
4.86
70°C, pH 7.4, mutant enzyme C259S/C261S/C262S/C200S/C205S
4.97
70°C, pH 7.4, mutant enzyme C262S
5.09
70°C, pH 7.4, mutant enzyme C259S/C261S
5.28
70°C, pH 7.4, mutant enzyme C259S/C261S/C262S/C200S/C205S/C138S/C164S
5.68
70°C, pH 7.4, mutant enzyme C259S/C261S/C262S
6.24
70°C, pH 7.4, mutant enzyme C259S/C261S/C262S/C200S/C205S/C138S
6.25
with 5'-methylthioadenosine as substrate
6.27
70°C, pH 7.4, wild-type enzyme
6.35
-
purified enzyme
9.5
-
purified recombinant enzyme
additional information