2.4.2.28: S-methyl-5'-thioadenosine phosphorylase
This is an abbreviated version!
For detailed information about S-methyl-5'-thioadenosine phosphorylase, go to the full flat file.
Word Map on EC 2.4.2.28
-
2.4.2.28
-
purine
-
polyamine
-
salvage
-
mtap-deficient
-
cdkn2a
-
mesothelioma
-
phosphorolysis
-
mesothelial
-
nucleosidase
-
codeleted
-
l-alanosine
-
co-deletion
-
mtap-deleted
-
phosphorylase-deficient
-
p15ink4b
-
5'-deoxyadenosine
-
5-methylthioribose
-
mtans
-
p14arf
-
enzyme-deficient
-
diagnostics
-
drug development
-
medicine
-
analysis
- 2.4.2.28
- purine
- polyamine
-
salvage
-
mtap-deficient
-
cdkn2a
- mesothelioma
-
phosphorolysis
-
mesothelial
- nucleosidase
-
codeleted
-
l-alanosine
-
co-deletion
-
mtap-deleted
-
phosphorylase-deficient
- p15ink4b
- 5'-deoxyadenosine
- 5-methylthioribose
-
mtans
-
p14arf
-
enzyme-deficient
- diagnostics
- drug development
- medicine
- analysis
Reaction
Synonyms
5'-deoxy-5'-methylthioadenosine phosphorylase, 5'-deoxy-5'-methylthioadenosine phosphorylase II, 5'-deoxy-5'-methylthioadenosine:orthophosphate methylthioribosyltransferase, 5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine phosphorylase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 5-methylthioadenosine phosphorylase, 5’-methylthioadenosine phosphorylase, MeSAdo phosphorylase, MeSAdo/Ado phosphorylase, methylthioadenosine nucleosidase, methylthioadenosine nucleoside phosphorylase, methylthioadenosine phosphorylase, MTA phosphorylase, MTAN, MTAN1, MTAN2, MTAP, Mtap protein, MTAPase, MTN1, MTN2, PfMTAP, phosphorylase, methylthioadenosine, RSFP, Rv0535, SsMTAP, SsMTAP II, SsMTAPII, SSO2343
ECTree
2.4.2.28 S-methyl-5'-thioadenosine phosphorylaseAdvanced search results
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results (Reference
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Reference on EC 2.4.2.28 - S-methyl-5'-thioadenosine phosphorylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pegg, A.E.; Williams-Ashman, H.G.
Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate
Biochem. J.
115
241-247
1969
Rattus norvegicus
Carteni'-Farina, M.; Oliva, A.; Romeo, G.; Napolitano, G.; De Rosa, M.; Gambacorta, A.; Zappia, V.
5'-Methylthioadenosine phosphorylase from Caldariella acidophila. Purification and properties
Eur. J. Biochem.
101
317-324
1979
Caldariella acidophila
Garbers, D.L.
Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung
Biochim. Biophys. Acta
523
82-93
1978
Rattus norvegicus
Lee, S.H.; Cho, Y.D.
Purification and properties of 5'-deoxy-5'methylthioadenosine phosphorylase from rat spleen
Korean Biochem. J.
26
433-439
1993
Rattus norvegicus
-
Cacciapuoti, G.; Porcelli, M.; Bertoldo, C.; Zappia, V.
Thermophilicity and thermostability of 5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus
Life Chem. Rep.
10
75-81
1992
Saccharolobus solfataricus
-
Toorchen, D.; Miller, R.L.
Purification and characterization of 5'-deoxy-5'-methylthioadenosine (MTA) phosphorylase from human liver
Biochem. Pharmacol.
41
2023-2030
1991
Homo sapiens
Savarese, T.M.; Harrington, S.; Nakamura, C.; Chen, Z.H.; Kumar, P.; Mikkilineni, A.; Abushanab, E.; Chu, S.H.; Parks, R.E.
5'-Deoxy-5'-methylthioadenosine phosphorylase. V. Acycloadenosine derivatives as inhibitors of the enzyme
Biochem. Pharmacol.
40
2465-2471
1990
Homo sapiens, Mus musculus
Ghoda, L.Y.; Savarese, T.M.; Northup, C.H.; Parks, R.E.; Garofalo, J.; Katz, L.; Ellenbogen, B.B.; Bacchi, C.J.
Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells
Mol. Biochem. Parasitol.
27
109-118
1988
Trypanosoma brucei brucei
Koszalka, G.W.; Krenitsky, T.A.
5'-Methyladenosine (MTA) phosphorylase from promastigotes of Leishmania donovani
Adv. Exp. Med. Biol.
195B
559-563
1986
Leishmania donovani
-
White, M.W.; Vandenbark, A.A.; Barney, C.L.; Ferro, A.J.
Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation
Biochem. Pharmacol.
31
503-507
1982
Homo sapiens
Shugart, L.; Mahoney, L.; Chastain, B.
Kinetic studies of Drosophila melanogaster methylthioadenosine nucleoside phosphorylase
Int. J. Biochem.
13
559-564
1981
Drosophila melanogaster
Savarese, T.M.; Crabtree, G.W.; Parks, R.E.
5'-Methylthioadenosine phosphorylase. I. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells
Biochem. Pharmacol.
30
189-199
1981
Mus musculus
Shugart, L.; Tancer, M.; Moore, J.
Methylthioadenosine nucleoside phosphorylase activity in Drosophila melangoaster
Int. J. Biochem.
10
901-904
1979
Drosophila melanogaster
Zappia, V.; Carteni-Farina, M.; Romeo, G.; De Rosa, M.; Gambacorta, A.
Purification and properties of 5'-methyladenosine phosphorylase from Caldariella acidophila
Methods Enzymol.
94
355-361
1983
Caldariella acidophila
-
Zappia, V.; Oliva, A.; Cacciapuoti, G.; Galletti, P.; Mignucci, G.; Carteni-Farina, M.
Substrate specificity of 5'-methylthioadenosine phosphorylase from human prostate
Biochem. J.
175
1043-1050
1978
Homo sapiens
Ferro, A.J.; Wrobel, N.C.; Nicolette, J.A.
5-Methylthioribose 1-phosphate: a product of partially purified, rat liver 5'-methylthioadenosine phosphorylase activity
Biochim. Biophys. Acta
570
65-73
1979
Rattus norvegicus
Della Ragione, F.; Carteni-Farina, M.; Gragnaniello, V.; Schettino, M.I.; Zappia, V.
Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta
J. Biol. Chem.
261
12324-12329
1986
Homo sapiens
Della Ragione, F.; Oliva, A.; Gragnaniello, V.; Russo, G.L.; Palumbo, R.; Zappia, V.
Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase
J. Biol. Chem.
265
6241-6246
1990
Bos taurus
Cacciapuoti, G.; Porcelli, M.; Bertoldo, C.; De Rosa, M.; Zappia, V.
Purification and characterization of extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Purine nucleoside phosphorylase activity and evidence for intersubunit disulfide bonds
J. Biol. Chem.
269
24762-24769
1994
Saccharolobus solfataricus, Saccharolobus solfataricus (P50389)
Fabianowska-Majewska, K.; Duley, J.; Fairbanks, L.; Simmonds, A.; Wasiak, T.
Substrate specificity of methylthioadenosine phosphorylase from human liver
Acta Biochim. Pol.
41
391-395
1994
Homo sapiens
Della Ragione, F.; Takabayashi, K.; Mastropietro, S.; Mercurio, C.; Oliva, A.; Russo, G.L.; Della Pietra, V.; Borriello, A.; Nobori, T.; et al.
Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification coding cDNA
Biochem. Biophys. Res. Commun.
223
514-519
1996
Homo sapiens
Nobori, T.; Takabayashi, K.; Tran, P.; Orvis, L.; Batova, A.; Yu, A.L.; Carson, D.A.
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers
Proc. Natl. Acad. Sci. USA
93
6203-6208
1996
Homo sapiens (Q13126), Homo sapiens
Yu, J.; Batova, A.; Shao, L.e.; Carrera, C.J.; Yu, A.L.
Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies
Clin. Cancer Res.
3
433-438
1997
Homo sapiens
Cacciapuoti, G.; Fusco, S.; Caiazzo, N.; Zappia, V.; Porcelli, M.
Heterologous expression of 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus: characterization of the recombinant protein and involvement of disulfide bonds in thermophilicity and thermostability
Protein Expr. Purif.
16
125-135
1999
Saccharolobus solfataricus, Saccharolobus solfataricus (P50389)
Bacchi, C.J.; Goldberg, B.; Rattendi, D.; Gorrell, T.E.; Spiess, A.J.; Sufrin, J.R.
Metabolic effects of a methylthioadenosine phosphorylase substrate analog on african trypanosomes
Biochem. Pharmacol.
57
89-96
1999
Trypanosoma brucei brucei
Appleby, T.C.; Erion, M.D.; Ealick, S.E.
The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis
Structure
7
629-641
1999
Homo sapiens
Slominska, E.M.; Kalsi, K.K.; Yacoub, M.H.; Smolenski, R.T.
The role of 5'-deoxy-5'-methyl thioadenosine phosphorylase in cardiac adenosine breakdown and adenine production
Adv. Exp. Med. Biol.
486
159-162
2000
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar, Sus scrofa
Tang, B.; Li, Y.N.; Kruger, W.D.
Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth
Cancer Res.
60
5543-5547
2000
Homo sapiens
Cacciapuoti, G.; Servillo, L.; Moretti, M.A.; Porcelli, M.
Conformational changes and stabilization induced by phosphate binding to 5'-methylthioadenosine phosphorylase from the thermophilic archaeon Sulfolobus solfataricus
Extremophiles
5
295-302
2001
Saccharolobus solfataricus
Appleby, T.C.; Mathews, I.I.; Porcelli, M.; Cacciapuoti, G.; Ealick, S.E.
Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus
J. Biol. Chem.
276
39232-39242
2001
Saccharolobus solfataricus, Saccharolobus solfataricus (P50389)
Cacciapuoti, G.; Bertoldo, C.; Brio, A.; Zappia, V.; Porcelli, M.
Purification and characterization of 5'-methylthioadenosine phosphorylase from the hyperthermophilic archaeon Pyrococcus furiosus. Substrate specificity and primary structure analysis
Extremophiles
7
159-168
2003
Pyrococcus furiosus
Behrmann, I.; Wallner, S.; Komyod, W.; Heinrich, P.C.; Schuierer, M.; Buettner, R.; Bosserhoff, A.K.
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma
Am. J. Pathol.
163
683-690
2003
Homo sapiens
Kadariya, Y.; Nishioka, J.; Nakatani, K.; Nakashima, K.; Nobori, T.
Deletion of dinucleotide repeat (DELTA14 allele) in the methylthioadenosine phosphorylase (MTAP) promoter and the allelotype of MTAP promoter in the Japanese population
Jpn. J. Cancer Res.
93
369-373
2002
Homo sapiens
Lee, J.E.; Settembre, E.C.; Cornell, K.A.; Riscoe, M.K.; Sufrin, J.R.; Ealick, S.E.; Howell, P.L.
Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design
Biochemistry
43
5159-5169
2004
Homo sapiens (Q13126), Homo sapiens
Singh, V.; Shi, W.; Evans, G.B.; Tyler, P.C.; Furneaux, R.H.; Almo, S.C.; Schramm, V.L.
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
Biochemistry
43
9-18
2004
Homo sapiens (Q13126), Homo sapiens
Kung, P.P.; Zehnder, L.R.; Meng, J.J.; Kupchinsky, S.W.; Skalitzky, D.J.; Johnson, M.C.; Maegley, K.A.; Ekker, A.; Kuhn, L.A.; Rose, P.W.; Bloom, L.A.
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates
Bioorg. Med. Chem. Lett.
15
2829-2833
2005
Homo sapiens
Cacciapuoti, G.; Moretti, M.A.; Forte, S.; Brio, A.; Camardella, L.; Zappia, V.; Porcelli, M.
Methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus. Mechanism of the reaction and assignment of disulfide bonds
Eur. J. Biochem.
271
4834-4844
2004
Pyrococcus furiosus
Cacciapuoti, G.; Forte, S.; Moretti, M.A.; Brio, A.; Zappia, V.; Porcelli, M.
A novel hyperthermostable 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus
FEBS J.
272
1886-1899
2005
Saccharolobus solfataricus
Subhi, A.L.; Diegelman, P.; Porter, C.W.; Tang, B.; Lu, Z.J.; Markham, G.D.; Kruger, W.D.
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites
J. Biol. Chem.
278
49868-49873
2003
Saccharomyces cerevisiae
Evans, G.B.; Furneaux, R.H.; Schramm, V.L.; Singh, V.; Tyler, P.C.
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase
J. Med. Chem.
47
3275-3281
2004
Homo sapiens
Wild, P.J.; Meyer, S.; Bataille, F.; Woenckhaus, M.; Ameres, M.; Vgt, T.; Landthaler, M.; Pauer, A.; Klinkhammer-Schalke, M.; Hofstaedter, F.; Bosserhoff, A.K.
Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors
Arch. Dermatol.
142
471-476
2006
Homo sapiens
Singh, V.; Schramm, V.L.
Transition-state structure of human 5-methylthioadenosine phosphorylase
J. Am. Chem. Soc.
128
14691-14696
2006
Homo sapiens
Evans, G.B.; Furneaux, R.H.; Lenz, D.H.; Painter, G.F.; Schramm, V.L.; Singh, V.; Tyler, P.C.
Second generation transition state analogue inhibitors of human 5-methylthioadenosine phosphorylase
J. Med. Chem.
48
4679-4689
2005
Homo sapiens
Karikari, C.A.; Mullendore, M.; Eshleman, J.R.; Argani, P.; Leoni, L.M.; Chattopadhyay, S.; Hidalgo, M.; Maitra, A.
Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers
Mol. Cancer Ther.
4
1860-1866
2005
Homo sapiens
Parker, W.B.; Allan, P.W.; Ealick, S.E.; Sorscher, E.J.; Hassan, A.E.; Silamkoti, A.V.; Fowler, A.T.; Waud, W.R.; Secrist, J.A.
Design and evaluation of 5-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant
Nucleosides Nucleotides Nucleic Acids
24
387-392
2005
Homo sapiens
Cacciapuoti, G.; Porcelli, M.; Bertoldo, C.; Fusco, S.; De Rosa, M.; Zappia, V.
Extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Gene cloning and amino acid sequence determination.
Eur. J. Biochem.
239
632-637
1996
Saccharolobus solfataricus (P50389), Saccharolobus solfataricus
Siu, K.K.; Lee, J.E.; Sufrin, J.R.; Moffatt, B.A.; McMillan, M.; Cornell, K.A.; Isom, C.; Howell, P.L.
Molecular determinants of substrate specificity in plant 5-methylthioadenosine nucleosidases
J. Mol. Biol.
378
112-128
2008
Escherichia coli, Arabidopsis thaliana (Q7XA67), Arabidopsis thaliana (Q9T0I8), Arabidopsis thaliana
Williamson, R.E.; Darrow, K.N.; Michaud, S.; Jacobs, J.S.; Jones, M.C.; Eberl, D.F.; Maas, R.L.; Liberman, M.C.; Morton, C.C.
Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis
Am. J. Med. Genet. A
143A
1630-1639
2007
Homo sapiens (Q13126)
Alhebshi, H.M.; Pant, I.; Kaur, G.; Hashim, H.; Mabruk, M.J.
Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma
Asian Pac. J. Cancer Prev.
9
291-294
2008
Homo sapiens
Fernandez-Irigoyen, J.; Santamaria, M.; Sanchez-Quiles, V.; Latasa, M.U.; Santamaria, E.; Munoz, J.; Sanchez Del Pino, M.M.; Valero, M.L.; Prieto, J.; Avila, M.A.; Corrales, F.J.
Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications
Biochem. J.
411
457-465
2008
Homo sapiens, Mus musculus (Q9CQ65)
Miyazaki, S.; Nishioka, J.; Shiraishi, T.; Matsumine, A.; Uchida, A.; Nobori, T.
Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients
Int. J. Oncol.
31
1069-1076
2007
Homo sapiens
Basu, I.; Cordovano, G.; Das, I.; Belbin, T.J.; Guha, C.; Schramm, V.L.
A transition state analogue of 5-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers
J. Biol. Chem.
282
21477-21486
2007
Homo sapiens
Watanabe, F.; Takao, M.; Inoue, K.; Nishioka, J.; Nobori, T.; Shiraishi, T.; Kaneda, M.; Sakai, T.; Yada, I.; Shimpo, H.
Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma
Lung Cancer
63
39-44
2008
Homo sapiens
Luo, M.; Schramm, V.L.
Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-2H kinetic isotope effect
J. Am. Chem. Soc.
130
11617-11619
2008
Streptococcus pneumoniae
Gutierrez, J.A.; Crowder, T.; Rinaldo-Matthis, A.; Ho, M.C.; Almo, S.C.; Schramm, V.L.
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing
Nat. Chem. Biol.
5
251-257
2009
Escherichia coli, Vibrio harveyi, Escherichia coli O157:H7 EDL933
Oh, S.I.; Park, J.; Yoon, S.; Kim, Y.; Park, S.; Ryu, M.; Nam, M.J.; Ok, S.H.; Kim, J.K.; Shin, J.S.; Kim, K.N.
The Arabidopsis calcium sensor calcineurin B-like 3 inhibits the 5'-methylthioadenosine nucleosidase in a calcium-dependent manner
Plant Physiol.
148
1883-1896
2008
Arabidopsis thaliana (Q9T0I8)
Park, E.Y.; Choi, W.S.; Oh, S.I.; Kim, K.N.; Shin, J.S.; Song, H.K.
Biochemical and structural characterization of 5-methylthioadenosine nucleosidases from Arabidopsis thaliana
Biochem. Biophys. Res. Commun.
381
619-624
2009
Arabidopsis thaliana (Q7XA67), Arabidopsis thaliana (Q9T0I8)
Kadariya, Y.; Yin, B.; Tang, B.; Shinton, S.A.; Quinlivan, E.P.; Hua, X.; Klein-Szanto, A.; Al-Saleem, T.I.; Bassing, C.H.; Hardy, R.R.; Kruger, W.D.
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma
Cancer Res.
69
5961-5969
2009
Mus musculus
Sommer, J.; Itani, D.M.; Homlar, K.C.; Keedy, V.L.; Halpern, J.L.; Holt, G.E.; Schwartz, H.S.; Coffin, C.M.; Kelley, M.J.; Cates, J.M.
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma
J. Pathol.
220
608-617
2010
Homo sapiens
Lubin, M.; Lubin, A.
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy
PLoS ONE
4
e5735
2009
Homo sapiens
Longshaw, A.I.; Adanitsch, F.; Gutierrez, J.A.; Evans, G.B.; Tyler, P.C.; Schramm, V.L.
Design and synthesis of potent sulfur-free transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase
J. Med. Chem.
53
6730-6746
2010
Escherichia coli
Zhang, Y.; Porcelli, M.; Cacciapuoti, G.; Ealick, S.E.
The crystal structure of 5-deoxy-5-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds
J. Mol. Biol.
357
252-262
2006
Saccharolobus solfataricus (Q97W94), Saccharolobus solfataricus
Zhang, Y.; Zwart, P.H.; Ealick, S.E.
A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II
Acta Crystallogr. Sect. D
68
249-252
2012
Saccharolobus solfataricus (Q97W94), Saccharolobus solfataricus P2 (Q97W94)
Guan, R.; Ho, M.C.; Brenowitz, M.; Tyler, P.C.; Evans, G.B.; Almo, S.C.; Schramm, V.L.
Entropy-driven binding of picomolar transition state analogue inhibitors to human 5-methylthioadenosine phosphorylase
Biochemistry
50
10408-10417
2011
Homo sapiens (Q13126), Homo sapiens
Cacciapuoti, G.; Marabotti, A.; Fuccio, F.; Porcelli, M.
Unraveling the structural and functional differences between purine nucleoside phosphorylase and 5-deoxy-5-methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus
Biochim. Biophys. Acta
1814
1358-1366
2011
Pyrococcus furiosus (Q8U4Q8), Pyrococcus furiosus
Cacciapuoti, G.; Fuccio, F.; Petraccone, L.; Del Vecchio, P.; Porcelli, M.
Role of disulfide bonds in conformational stability and folding of 5-deoxy-5-methylthioadenosine phosphorylase II from the hyperthermophilic archaeon Sulfolobus solfataricus
Biochim. Biophys. Acta
1824
1136-1143
2012
Saccharolobus solfataricus
Buckoreelall, K.; Sun, Y.; Hobrath, J.V.; Wilson, L.; Parker, W.B.
Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis
Tuberculosis
92
139-147
2012
Mycobacterium tuberculosis (O06401), Mycobacterium tuberculosis
Porcelli, M.; Cacciapuoti, G.; Fusco, S.; Massa, R.; d'Ambrosio, G.; Bertoldo, C.; De Rosa, M.; Zappia, V.
Non-thermal effects of microwaves on proteins: thermophilic enzymes as model system
FEBS Lett.
402
102-106
1997
Saccharolobus solfataricus
Kang, X.; Zhao, Y.; Jiang, D.; Li, X.; Wang, X.; Wu, Y.; Chen, Z.; Zhang, X.C.
Crystal structure and biochemical studies of Brucella melitensis 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Biochem. Biophys. Res. Commun.
446
965-970
2014
Brucella melitensis (Q8YBL1)
Bagarolo, M.L.; Porcelli, M.; Martino, E.; Feller, G.; Cacciapuoti, G.
Multiple disulfide bridges modulate conformational stability and flexibility in hyperthermophilic archaeal purine nucleoside phosphorylase
Biochim. Biophys. Acta
1854
1458-1465
2015
Saccharolobus solfataricus (Q97W94), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97W94)
Guan, R.; Tyler, P.C.; Evans, G.B.; Schramm, V.L.
Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase
Biochemistry
52
8313-8322
2013
Homo sapiens (Q13126), Homo sapiens
Lv, X.; Zhang, Y.; Rao, S.; Su, D.; Feng, D.; Wang, M.; Li, X.; Li, D.; Guo, H.; Zuo, X.; Xia, M.; Ouyang, H.; Ling, W.; Qiu, J.
Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans
Gene
526
344-346
2013
Homo sapiens (Q13126), Homo sapiens
Vodnala, M.; Ranjbarian, F.; Pavlova, A.; de Koning, H.P.; Hofer, A.
Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine: implications for the pharmacology of adenosine antimetabolites
J. Biol. Chem.
291
11717-11726
2016
Trypanosoma brucei, Trypanosoma brucei TC221
Bistulfi, G.; Affronti, H.C.; Foster, B.A.; Karasik, E.; Gillard, B.; Morrison, C.; Mohler, J.; Phillips, J.G.; Smiraglia, D.J.
The essential role of methylthioadenosine phosphorylase in prostate cancer
Oncotarget
7
14380-14393
2016
Homo sapiens (Q13126), Homo sapiens
Becker, A.P.; Scapulatempo-Neto, C.; Menezes, W.P.; Clara, C.; Machado, H.R.; Oliveira, R.S.; Neder, L.; Reis, R.M.
Expression of methylthioadenosine phosphorylase (MTAP) in pilocytic astrocytomas
Pathobiology
82
84-89
2015
Homo sapiens
Bartasun, P.; Cieslinski, H.; Bujacz, A.; Wierzbicka-Wos, A.; Kur, J.
A study on the interaction of rhodamine B with methylthioadenosine phosphorylase protein sourced from an antarctic soil metagenomic library
PLoS ONE
8
e55697
2013
uncultured bacterium (C6KFA4)
Czech, B.; Dettmer, K.; Valletta, D.; Saugspier, M.; Koch, A.; Stevens, A.P.; Thasler, W.E.; Mueller, M.; Oefner, P.J.; Bosserhoff, A.K.; Hellerbrand, C.
Expression and function of methylthioadenosine phosphorylase in chronic liver disease
PLoS ONE
8
e80703
2013
Homo sapiens
Firestone, R.S.; Cameron, S.A.; Karp, J.M.; Arcus, V.L.; Schramm, V.L.
Heat capacity changes for transition-state analogue binding and catalysis with human 5'-methylthioadenosine phosphorylase
ACS Chem. Biol.
12
464-473
2017
Homo sapiens
Abid, H.; Harigua-Souiai, E.; Mejri, T.; Barhoumi, M.; Guizani, I.
Leishmania infantum 5'-methylthioadenosine phosphorylase presents relevant structural divergence to constitute a potential drug target
BMC Struct. Biol.
17
9-9
2017
Leishmania infantum, Leishmania infantum LV50
Torini, J.R.; Brandao-Neto, J.; DeMarco, R.; Pereira, H.D.
Crystal structure of Schistosoma mansoni adenosine phosphorylase/5'-methylthioadenosine phosphorylase and its importance on adenosine salvage pathway
PLoS Negl. Trop. Dis.
10
e0005178
2016
Schistosoma mansoni (I0B503), Schistosoma mansoni
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