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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
-
-
-
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
Pigeon
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism, kinetic model
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism, regulation
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
catalytic phosphorylation of His residues is essential, overview
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
catalytic site structure and interactions involving residues H258, E327, H392, R397, and H446, detailed molecular mechanism and regulation in wild-type and mutant enzymes, overview, catalytic phosphorylation of His residues is essential, overview
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
substrate binding loop structure and regulation mechanism, interactions of enzyme and substrate involve residues K47, R74, R75, R98, and T126, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
beta-D-fructose 2,6-bisphosphate induces a global conformational change in the absence of AMP
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
in-line phosphoryl transfer initiated by a substrate-assisted mechanism
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
the complex of E. coli FBPase with beta-D-fructose 2,6-bisphosphate remains in the R-state with dynamic loops in the engaged conformation
-
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beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
fructose 2,6-bisphosphate + H2O
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
additional information
?
-
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
regulation mechanism, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
substrate binding loop structure, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
Pigeon
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952 -
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
Pigeon
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
fructose 2-phosphate + phosphate
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
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?
additional information
?
-
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biological factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, metabolic regulation overview
-
-
?
additional information
?
-
-
catalytic cycle of the catalytic domain of fructose-2 6-biphosphatase, overview, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two activities, involved in glycolysis and gluconeogenesis, regulation overview
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-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
enzyme expression is highly reduced in diabetic mice, insulin is required for enzyme induction/regulation, a high enzyme expression level reduces blood glucose level and increases the expression of glucokinase, metabolic regulation overview
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?
additional information
?
-
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metabolic regulation, overview
-
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?
additional information
?
-
-
PFKFB3 overexpression increases the glycolysis level
-
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?
additional information
?
-
study of bifunctional enzyme evolution
-
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?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
enzyme involved in regulation of glycolytic flux, role of glycolysis in cell cycle progression
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biolocical factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, involved in glycolysis and gluconeogenesis, metabolic regulation overview
-
-
?
additional information
?
-
-
catalytic cycle of the catalytic domain of fructose-2 6-biphosphatase, overview
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
-
?
additional information
?
-
-
activation of glucokinase is endogenously mediated by interaction with the bisphosphatase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase which increases the phosphorylating capacity of glucokinase
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
additional information
?
-
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
regulation mechanism, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
Pigeon
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952 -
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
-
?
additional information
?
-
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biological factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, metabolic regulation overview
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
enzyme expression is highly reduced in diabetic mice, insulin is required for enzyme induction/regulation, a high enzyme expression level reduces blood glucose level and increases the expression of glucokinase, metabolic regulation overview
-
-
?
additional information
?
-
-
metabolic regulation, overview
-
-
?
additional information
?
-
-
PFKFB3 overexpression increases the glycolysis level
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
enzyme involved in regulation of glycolytic flux, role of glycolysis in cell cycle progression
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biolocical factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, involved in glycolysis and gluconeogenesis, metabolic regulation overview
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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(2E)-2-(1,3-benzodioxol-5-ylmethylidene)butanedioic acid
-
mimics binding pattern of fructose 6-phosphate
([2-[(5-nitropyridin-2-yl)amino]phenyl]sulfanyl)acetic acid
-
mimics binding pattern of fructose 6-phosphate
1,1'-ethane-1,2-diylbis(4-acetylpyrrolidine-2,3,5-trione)
-
mimics binding pattern of fructose 6-phosphate
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethanol
-
mimics binding pattern of fructose 6-phosphate
1-(3-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
-
1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
-
1-amino-4-(2-nitro-1H-imidazol-1-yl)butan-2-ol
-
mimics binding pattern of fructose 6-phosphate
2,5-anhydro-D-mannitol 6-phosphate
-
-
2-((5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)amino)acetamide
-
-
2-(1,3-benzodioxol-5-ylmethyl)-3-methylbutanedioic acid
-
mimics binding pattern of fructose 6-phosphate
2-(2-nitrophenoxy)-N-phenylacetamide
-
mimics binding pattern of fructose 6-phosphate
2-(3H-indol-7-ylmethyl)butanedioic acid
-
mimics binding pattern of fructose 6-phosphate
2-(5-amino-4-carbamoyl-1H-pyrazol-1-yl)ethanesulfonic acid
-
mimics binding pattern of fructose 6-phosphate
2-(5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)-1,2,3,4-tetrahydroisoquinoline-5-carbonitrile
-
-
2-(acetylamino)-beta-oxophenylalanine
-
mimics binding pattern of fructose 6-phosphate
2-nitro-N-(pyrazin-2-ylmethyl)benzenesulfonamide
-
mimics binding pattern of fructose 6-phosphate
2-nitro-N-quinolin-3-ylbenzenesulfonamide
-
mimics binding pattern of fructose 6-phosphate
2-[(4-nitro-1H-benzimidazol-7-yl)sulfanyl]ethyl benzoate
-
mimics binding pattern of fructose 6-phosphate
2-[(5-nitropyridin-2-yl)amino]ethyl 5-nitro-1H-pyrrole-2-carboxylate
-
mimics binding pattern of fructose 6-phosphate
2-[(furan-2-ylmethyl)amino]-5-nitrobenzoic acid
-
mimics binding pattern of fructose 6-phosphate
2-[[(2Z)-2-(phenylhydrazono)acetyl]amino]benzoic acid
-
mimics binding pattern of fructose 6-phosphate
2-[[2-(2,4-dinitrophenyl)hydrazino]carbonyl]benzoic acid
-
mimics binding pattern of fructose 6-phosphate
3,3'-(2,4,6-trioxo-1,3,5-triazinane-1,3-diyl)dipropanoic acid
-
mimics binding pattern of fructose 6-phosphate
3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)-N-(tetrahydrofuran-2-ylmethyl)propanamide
-
mimics binding pattern of fructose 6-phosphate
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
-
-
3-acetylphenyl (3-acetylphenyl)acetate
-
mimics binding pattern of fructose 6-phosphate
3-[(2-pyridin-2-ylhydrazino)carbonyl]pyrazine-2-carboxylic acid
-
mimics binding pattern of fructose 6-phosphate
4-(4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-bromo-6-oxopyridazin-1(6H)-yl)benzonitrile
-
-
4-bromo-2-phenyl-5-(((tetrahydrofuran-2-yl)methyl)amino)pyridazin-3(2H)-one
-
-
4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one
-
-
4-bromo-5-morpholino-2-phenylpyridazin-3(2H)-one
-
-
5,6,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
-
competitive inhibitor
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzyl-4-bromopyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(3-phenylpropyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-((2-(dimethylamino)ethyl)-amino)benzyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-(trifluoromethoxy)phenyl)-pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-chlorophenyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-iodobenzyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(pyrimidin-5-yl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenethylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-chloro-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-ethoxy-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-iodo-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-isopropyl-2-phenylpyridazin-3(2H)-one
-
-
5-hydroxy-N-(4-nitro-1,3-thiazol-2-yl)-2,4-dioxopentanamide
-
mimics binding pattern of fructose 6-phosphate
citrate
-
inhibits the cardiac enzyme
Cyclic AMP dependent protein kinase
-
causes inactivation
-
D-fructose-1,6-bisphosphate
-
D-glucose-1,6-bisphosphate
-
D-psicose 6-phosphate
-
poor inhibitor
D-ribose 5-phosphate
-
poor inhibitor
D-tagatose 6-phosphate
-
poor inhibitor
diethyldicarbonate
-
inactivation
dimethyloxalylglycine
inhibits the splice isozyme PFKFB-4
ethyl 1-(6-oxo-1-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1,6-dihydropyridazin-4-yl)-1H-1,2,3-triazole-4-carboxylate
-
-
F-
-
in presence of glycerol 3-or 2-phosphate
Insulin
-
opposes action of glucagon or epinephrine
-
L-Sorbose 6-phosphate
-
-
N-bromoacetylethanolamine
AMP
-
beta-D-fructose 2,6-bisphosphate has no effect on AMP inhibition
AMP
-
beta-D-fructose 2,6-bisphosphate enhances AMP inhibition
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
mixed type
fructose 6-phosphate
-
noncompetetive
fructose 6-phosphate
-
noncompetetive
fructose 6-phosphate
Pigeon
-
-
fructose 6-phosphate
-
noncompetetive
glycerol 1-phosphate
-
inhibition at low substrate concentrations
glycerol 1-phosphate
-
inhibits at subsaturating substrate concentrations
N-bromoacetylethanolamine
-
-
N-bromoacetylethanolamine
-
-
phosphate
-
phosphate
-
inhibition at low substrate concentrations
phosphate
-
inhibits at subsaturating substrate concentrations
vanadate
-
50% inhibition at 0.15 mM
additional information
not inhibitory: diphosphate
-
additional information
-
not inhibitory: diphosphate
-
additional information
-
expression of isozyme PFKFB3 is reduced by treatment of 3T3-L1 cells with insulin
-
additional information
-
inhibitor screening and structure-based docking, overview
-
additional information
-
expression of isozyme PFKFB3 is reduced by prolonged treatment of 3T3-L1 cells with insulin
-
additional information
-
streptozotocin highly reduces enzyme expression, treated mice show undetecable low levels of insulin, the effect is reversible by application of insulin
-
additional information
a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months; a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months
-
additional information
a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months; a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months
-
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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1
2-((5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)amino)acetamide
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.5
2-(5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)-1,2,3,4-tetrahydroisoquinoline-5-carbonitrile
Homo sapiens
-
IC50 above 0.5 mM,in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.026
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0084
4-(4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-bromo-6-oxopyridazin-1(6H)-yl)benzonitrile
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
1
4-bromo-2-phenyl-5-(((tetrahydrofuran-2-yl)methyl)amino)pyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
1
4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
1
4-bromo-5-morpholino-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM,in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0034
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzyl-4-bromopyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
10
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 10 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.011
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(3-phenylpropyl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.5
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-((2-(dimethylamino)ethyl)-amino)benzyl)pyridazin-3(2H)-one
Homo sapiens
-
IC50 above 0.5 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0091
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-(trifluoromethoxy)phenyl)-pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.007
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-chlorophenyl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0087
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-iodobenzyl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0096
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(pyrimidin-5-yl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0026
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenethylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0074
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.0262
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-chloro-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
1
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-ethoxy-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.013
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-iodo-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.5
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-isopropyl-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 0.5 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
0.055
ethyl 1-(6-oxo-1-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1,6-dihydropyridazin-4-yl)-1H-1,2,3-triazole-4-carboxylate
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C
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Rattus norvegicus
brenda
Wang, Q.; Donthi, R.V.; Wang, J.; Lange, A.J.; Watson, L.J.; Jones, S.P.; Epstein, P.N.
Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia
Am. J. Physiol. Heart Circ. Physiol.
294
H2889-H2897
2008
Rattus norvegicus
brenda
Mykhalchenko, V.G.; Minchenko, D.O.; Tsuchihara, K.; Moenner, M.; Komisarenko, S.V.; Bikfalvi, A.; Esumi, H.; Minchenko, O.H.
Expression of mouse 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 mRNA alternative splice variants in hypoxia
Ukr. Biokhim. Zh.
80
19-25
2008
Mus musculus (Q3U3S6), Mus musculus
brenda
Minchenko, D.O.; Mykhalchenko, V.G.; Tsuchihara, K.; Kanehara, S.; Yavorovsky, O.P.; Zaygorodny, I.V.; Paustovsky, Y.O.; Komisarenko, S.V.; Esumi, H.; Minchenko, O.H.
Alternative splice variants of rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 mRNA
Ukr. Biokhim. Zh.
80
66-73
2008
Rattus norvegicus (B0ZTI0), Rattus norvegicus (P25114)
brenda
Myers, R.W.; Baginsky, W.F.; Gattermeir, D.J.; Geissler, W.M.; Harris, G.
Enzymatic preparation of high-specific-activity beta-D-[6,6-3H]fructose-2,6-bisphosphate: application to a sensitive assay for fructose-2,6-bisphosphatase
Anal. Biochem.
406
97-104
2010
Homo sapiens
brenda
Crochet, R.B.; Cavalier, M.C.; Seo, M.; Kim, J.D.; Yim, Y.S.; Park, S.J.; Lee, Y.H.
Investigating: a case study for small molecule kinases
Anal. Biochem.
418
143-148
2011
Homo sapiens
brenda
Moon, J.S.; Jin, W.J.; Kwak, J.H.; Kim, H.J.; Yun, M.J.; Kim, J.W.; Park, S.W.; Kim, K.S.
Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells
Biochem. J.
433
225-233
2011
Homo sapiens
brenda
Langer, S.; Kaminski, M.T.; Lenzen, S.; Baltrusch, S.
Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent
Mol. Endocrinol.
24
1988-1997
2010
Rattus norvegicus
brenda
Baltrusch, S.; Schmitt, H.; Brix, A.; Langer, S.; Lenzen, S.
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
Biochem. Pharmacol.
83
1300-1306
2012
Rattus norvegicus
brenda
Langer, S.; Okar, D.A.; Schultz, J.; Lenzen, S.; Baltrusch, S.
Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation
FEBS Lett.
586
1419-1425
2012
Rattus norvegicus
brenda
Brooke, D.G.; van Dam, E.M.; Watts, C.K.; Khoury, A.; Dziadek, M.A.; Brooks, H.; Graham, L.J.; Flanagan, J.U.; Denny, W.A.
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
Bioorg. Med. Chem.
22
1029-1039
2014
Homo sapiens
brenda
Ros, S.; Schulze, A.
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
Cancer Metab.
1
8-8
2013
Homo sapiens
brenda
Pegoraro, C.; Maczkowiak, F.; Monsoro-Burq, A.H.
Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) isoforms display a tissue-specific and dynamic expression during Xenopus laevis development
Gene Expr. Patterns
13
203-211
2013
Xenopus laevis
brenda
Novellasdemunt, L.; Tato, I.; Navarro-Sabate, A.; Ruiz-Meana, M.; Mendez-Lucas, A.; Perales, J.C.; Garcia-Dorado, D.; Ventura, F.; Bartrons, R.; Rosa, J.L.
Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids
J. Biol. Chem.
288
10640-10651
2013
Rattus norvegicus, Homo sapiens (O60825), Homo sapiens
brenda
Chesney, J.; Clark, J.; Klarer, A.C.; Imbert-Fernandez, Y.; Lane, A.N.; Telang, S.
Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth
Oncotarget
5
6670-6686
2014
Homo sapiens (Q16877), Homo sapiens
brenda
Merrins, M.J.; Bertram, R.; Sherman, A.; Satin, L.S.
Phosphofructo-2-kinase/fructose-2,6-bisphosphatase modulates oscillations of pancreatic islet metabolism
PLoS ONE
7
e34036
2012
Mus musculus
brenda
Cavalier, M.C.; Kim, S.G.; Neau, D.; Lee, Y.H.
Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: transition state and the C-terminal function
Proteins
80
1143-1153
2012
Homo sapiens (Q16875), Homo sapiens
brenda
Lea, M.A.; Guzman, Y.; Desbordes, C.
Inhibition of growth by combined treatment with inhibitors of lactate dehydrogenase and either phenformin or inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Anticancer Res.
36
1479-1488
2016
Homo sapiens (Q16875)
brenda
Yalcin, A.; Solakoglu, T.H.; Ozcan, S.C.; Guzel, S.; Peker, S.; Celikler, S.; Balaban, B.D.; Sevinc, E.; Gurpinar, Y.; Chesney, J.A.
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor beta1-enhanced invasion of Panc1 cells invitro
Biochem. Biophys. Res. Commun.
484
687-693
2017
Homo sapiens (Q16875)
brenda
Tang, Y.; Kwon, H.; Neel, B.A.; Kasher-Meron, M.; Pessin, J.B.; Yamada, E.; Pessin, J.E.
The fructose-2,6-bisphosphatase TIGAR suppresses NF-kappaB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC
J. Biol. Chem.
293
7578-7591
2018
Mus musculus (Q8BZA9)
brenda
Ros, S.; Floeter, J.; Kaymak, I.; Da Costa, C.; Houddane, A.; Dubuis, S.; Griffiths, B.; Mitter, R.; Walz, S.; Blake, S.; Behrens, A.; Brindle, K.M.; Zamboni, N.; Rider, M.H.; Schulze, A.
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells
Oncogene
36
3287-3299
2017
Homo sapiens (Q16877)
brenda
Du, J.Y.; Wang, L.F.; Wang, Q.; Yu, L.D.
miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells
Oncol. Rep.
33
1890-1898
2015
Homo sapiens (Q16875), Homo sapiens
brenda
Yan, S.; Wei, X.; Xu, S.; Sun, H.; Wang, W.; Liu, L.; Jiang, X.; Zhang, Y.; Che, Y.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway
Oncotarget
8
80909-80922
2017
Homo sapiens (Q16875)
brenda
Crochet, R.; Kim, J.; Lee, H.; Yim, Y.; Kim, S.; Neau, D.; Lee, Y.
Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding
Proteins
85
117-124
2017
Homo sapiens (O60825), Homo sapiens, Bos taurus (P26285), Bos taurus
brenda