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Literature summary for 3.1.3.46 extracted from
- Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260 (2012), Biochem. Pharmacol., 83, 1300-1306.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in RINm5F-GK cells | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O | Rattus norvegicus | - |
D-fructose 6-phosphate + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| pancreatic islet | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | D-fructose 6-phosphate + phosphate | - |
? | |
| additional information | activation of glucokinase is endogenously mediated by interaction with the bisphosphatase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase which increases the phosphorylating capacity of glucokinase | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | bifunctional enzyme | Rattus norvegicus |
| Pfk-2 | - |
Rattus norvegicus |
| PFK-2/FBPase-2 | - |
Rattus norvegicus |
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