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Literature summary for 3.1.3.46 extracted from
- Covalent control of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: Insights into autoregulation of a bifunctional enzyme (1995), Protein Sci., 4, 1023-1037.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cyclic AMP dependent protein kinase | catalyzes phosphorylation at a single NH2-terminal residue, Ser-32 | Rattus norvegicus | |
| glycerol 1-phosphate | activates at saturating substrate concentrations | Rattus norvegicus |  |
| phosphate | activates at saturating substrate concentrations | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycerol 1-phosphate | inhibits at subsaturating substrate concentrations | Rattus norvegicus | |
| phosphate | inhibits at subsaturating substrate concentrations | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fructose 2,6-bisphosphate + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| copurification with phosphofructokinase 2 | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | fructose 6-phosphate + phosphate | - |
? | |
| fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
fructose 2,6-bisphosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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