Literature summary for 3.1.3.46 extracted from

Zhu, Z.; Ling, S.; Yang, Q.H.; Li, L.
Involvement of the chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase sequence His444-Arg-Glu-Arg in modulation of the bisphosphatase activity by its kinase domain (2001), Biochem. J., 357, 513-520.

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Protein Variants

Protein Variants	Comment	Organism
H444A/R445A/R447A	enhances catalytic rate of bisphosphatase activity and abrogates inhibition by kinase domain	Gallus gallus
additional information	truncation of the C-terminus by 25, but not by 20 amino acids enhances catalytic rate of bisphosphatase activity and abrogates inhibition by kinase domain	Gallus gallus

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation by proteinkinase A activates bisphosphatase activity or abolishes inhibitory effect of kinase domain	Gallus gallus

Reaction

Reaction	Comment	Organism	Reaction ID
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate	mechanism, regulation	Gallus gallus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Gallus gallus	-

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Release 2023.1 (January 2023)