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Literature summary for 3.1.3.46 extracted from

  • Yalcin, A.; Solakoglu, T.H.; Ozcan, S.C.; Guzel, S.; Peker, S.; Celikler, S.; Balaban, B.D.; Sevinc, E.; Gurpinar, Y.; Chesney, J.A.
    6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor beta1-enhanced invasion of Panc1 cells invitro (2017), Biochem. Biophys. Res. Commun., 484, 687-693 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16875 isoform PFKFB3, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively
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Source Tissue

Source Tissue Comment Organism Textmining
PANC-1 cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function Transforming growth factor TGFbeta1 induces isoform PFKFB3 expression and stimulates glycolysis in Panc1 cells. siRNA silencing of PFKFB3 prevents the stimulation of glycolysis and in vitro invasion ability of Panc1 cells by TGFbeta1. PFKFB3 silencing suppresses the TGFbeta1-mediated induction of the Snail protein Homo sapiens