Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16875 | isoform PFKFB3, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PANC-1 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | Transforming growth factor TGFbeta1 induces isoform PFKFB3 expression and stimulates glycolysis in Panc1 cells. siRNA silencing of PFKFB3 prevents the stimulation of glycolysis and in vitro invasion ability of Panc1 cells by TGFbeta1. PFKFB3 silencing suppresses the TGFbeta1-mediated induction of the Snail protein | Homo sapiens |