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Literature summary for 3.1.3.46 extracted from

  • Shaikh, M.S.; Mittal, A.; Bharatam, P.V.
    Design of fructose-2,6-bisphosphatase inhibitors: A novel virtual screening approach (2008), J. Mol. Graph. Model., 26, 900-906.
    View publication on PubMed

Application

Application Comment Organism
pharmacology a pharmacophore map is generated and validated to identify inhibitors of the F6P–FBPase complex Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-(1,3-benzodioxol-5-ylmethylidene)butanedioic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
([2-[(5-nitropyridin-2-yl)amino]phenyl]sulfanyl)acetic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
1,1'-ethane-1,2-diylbis(4-acetylpyrrolidine-2,3,5-trione) mimics binding pattern of fructose 6-phosphate Homo sapiens
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethanol mimics binding pattern of fructose 6-phosphate Homo sapiens
1-amino-4-(2-nitro-1H-imidazol-1-yl)butan-2-ol mimics binding pattern of fructose 6-phosphate Homo sapiens
2-(1,3-benzodioxol-5-ylmethyl)-3-methylbutanedioic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
2-(2-nitrophenoxy)-N-phenylacetamide mimics binding pattern of fructose 6-phosphate Homo sapiens
2-(3H-indol-7-ylmethyl)butanedioic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
2-(5-amino-4-carbamoyl-1H-pyrazol-1-yl)ethanesulfonic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
2-(acetylamino)-beta-oxophenylalanine mimics binding pattern of fructose 6-phosphate Homo sapiens
2-nitro-N-(pyrazin-2-ylmethyl)benzenesulfonamide mimics binding pattern of fructose 6-phosphate Homo sapiens
2-nitro-N-quinolin-3-ylbenzenesulfonamide mimics binding pattern of fructose 6-phosphate Homo sapiens
2-[(4-nitro-1H-benzimidazol-7-yl)sulfanyl]ethyl benzoate mimics binding pattern of fructose 6-phosphate Homo sapiens
2-[(5-nitropyridin-2-yl)amino]ethyl 5-nitro-1H-pyrrole-2-carboxylate mimics binding pattern of fructose 6-phosphate Homo sapiens
2-[(furan-2-ylmethyl)amino]-5-nitrobenzoic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
2-[[(2Z)-2-(phenylhydrazono)acetyl]amino]benzoic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
2-[[2-(2,4-dinitrophenyl)hydrazino]carbonyl]benzoic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
3,3'-(2,4,6-trioxo-1,3,5-triazinane-1,3-diyl)dipropanoic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)-N-(tetrahydrofuran-2-ylmethyl)propanamide mimics binding pattern of fructose 6-phosphate Homo sapiens
3-acetylphenyl (3-acetylphenyl)acetate mimics binding pattern of fructose 6-phosphate Homo sapiens
3-[(2-pyridin-2-ylhydrazino)carbonyl]pyrazine-2-carboxylic acid mimics binding pattern of fructose 6-phosphate Homo sapiens
5-hydroxy-N-(4-nitro-1,3-thiazol-2-yl)-2,4-dioxopentanamide mimics binding pattern of fructose 6-phosphate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O
-
Homo sapiens D-fructose 6-phosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
Homo sapiens
FBPase-2
-
Homo sapiens
fructose-2,6-bisphosphatase
-
Homo sapiens