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Literature summary for 3.1.3.46 extracted from

  • Algaier, J.; Uyeda, K.
    Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase (1988), Biochem. Biophys. Res. Commun., 153, 328-333.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fructose 6-phosphate noncompetetive Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0043
-
fructose 2,6-bisphosphate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fructose 2,6-bisphosphate + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fructose 2,6-bisphosphate + H2O
-
Homo sapiens fructose 6-phosphate + phosphate
-
?
fructose 2,6-bisphosphate + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer 1* 36600 and 1* 35600 which seems a degradation product of the larger subunit, SDS-PAGE Homo sapiens