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Literature summary for 3.1.3.46 extracted from

  • Yan, S.; Wei, X.; Xu, S.; Sun, H.; Wang, W.; Liu, L.; Jiang, X.; Zhang, Y.; Che, Y.
    6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway (2017), Oncotarget, 8, 80909-80922 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
K472/473A mutant fails to localize in nucleus, mainly localizes in cytoplasm. The mutant inhibits the autophagic process, stimulates lactate production, and decreases the activity of AMPK compared to the wild-type Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
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nucleus
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Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q16875 isoform PFKFB3, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively
-

Source Tissue

Source Tissue Comment Organism Textmining
ACHN cell
-
Homo sapiens
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HeLa cell
-
Homo sapiens
-

General Information

General Information Comment Organism
physiological function both a PFKFB3 inhibitor or PFKFB3 silencing by siRNA suppress the basal and the H2O2-induced autophagy concomitantly with the inhibition of AMPK activity. Overexpression of wild-type PFKFB3 promotes H2O2-induced autophagy, but mutant K472/473A, which lost nuclear localizing property, inhibits the autophagic process. The K472/473A mutant stimulates more lactate production, and decreases the activity of AMPK compared to the wild-type Homo sapiens