Literature summary for 3.1.3.46 extracted from

Massa, L.; Baltrusch, S.; Okar, D.A.; Lange, A.J.; Lenzen, S.; Tiedge, M.
Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells (2004), Diabetes, 53, 1020-1029.

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Application

Application	Comment	Organism
medicine	overexpression of enzyme results in increase of glucokinase activity, interaction of enzyme with glucokinase at concentrations of glucose physiologically relevant for glucokinase activation, possible site for intervention in type 2 diabetes treatment	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-
pancreas	-	Rattus norvegicus	-

Subunits

Subunits	Comment	Organism
More	interaction of enzyme with glucokinase, mechanism of posttranslational glucokinase regulation	Rattus norvegicus

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Release 2023.1 (January 2023)