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Literature summary for 3.1.3.46 extracted from
- Vanadate inhibits liver fructose-2,6-bisphosphatase (1990), Eur. J. Biochem., 190, 53-56.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glycerol 1-phosphate | - |
Gallus gallus |  |
| Glycerol 2-phosphate | - |
Gallus gallus | |
| MgGTP2- | - |
Gallus gallus | |
| phosphate | - |
Gallus gallus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| vanadate | 50% inhibition at 0.15 mM | Gallus gallus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fructose 2,6-bisphosphate + H2O | Gallus gallus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fructose 2,6-bisphosphate + H2O | - |
Gallus gallus | fructose 6-phosphate + phosphate | - |
? | |
| fructose 2,6-bisphosphate + H2O | - |
Gallus gallus | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
vanadate | - |
Gallus gallus | |
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