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Literature summary for 3.1.3.46 extracted from

  • Pilkis, S.J.; Chrisman, T.; Burgress, B.; McGrane, M.; Colosia, A.; Pilkis, J.; Claus, T.H.; El-Maghrabi, M.R.
    Rat hepatic 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: a unique bifunctional enzyme (1983), Adv. Enzyme Regul., 21, 147-173.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
Cyclic AMP dependent protein kinase
-
 Rattus norvegicus
epinephrine
-
 Rattus norvegicus
glucagon
-
 Rattus norvegicus
glycerol 1-phosphate
-
 Rattus norvegicus
phosphate
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
fructose 6-phosphate
-
 Rattus norvegicus
Insulin opposes action of glucagon or epinephrine Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 gel filtration Rattus norvegicus
110000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fructose 2,6-bisphosphate + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus fructose 6-phosphate + phosphate
-
 ?
fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 50000-55000, SDS-PAGE Rattus norvegicus