Literature summary for 3.1.3.46 extracted from

Minchenko, D.O.; Mykhalchenko, V.G.; Tsuchihara, K.; Kanehara, S.; Yavorovsky, O.P.; Zaygorodny, I.V.; Paustovsky, Y.O.; Komisarenko, S.V.; Esumi, H.; Minchenko, O.H.
Alternative splice variants of rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 mRNA (2008), Ukr. Biokhim. Zh., 80, 66-73.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months; a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	B0ZTI0	splice variant	-
Rattus norvegicus	P25114	splice variant	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
beta-D-fructose 2,6-bisphosphate + H2O	-	Rattus norvegicus	D-fructose 6-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4	-	Rattus norvegicus
PFKFB-4	isoform, bifunctional enzyme	Rattus norvegicus

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Release 2023.1 (January 2023)